DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10738 and ADCY2

DIOPT Version :9

Sequence 1:NP_729905.2 Gene:CG10738 / 39516 FlyBaseID:FBgn0036368 Length:1250 Species:Drosophila melanogaster
Sequence 2:NP_065433.2 Gene:ADCY2 / 108 HGNCID:233 Length:1091 Species:Homo sapiens


Alignment Length:355 Identity:95/355 - (26%)
Similarity:166/355 - (46%) Gaps:67/355 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   863 MAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLK-------KG---------- 910
            :|:.:.|.:.... :..|. :|:.||::.:.||..:||..:|.::|       :|          
Human   214 LALQQTYQDTCNC-IKSRI-KLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTN 276

  Fly   911 --HKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAY 973
              |.:..:.:..|||.::||||||.::::|:|.::|..||:|:..||.|....:..:::.:||.|
Human   277 NFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCY 341

  Fly   974 MVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRY 1038
            ..|||||:...: ||.....|.|.:..|:.  |:|......:.:|:|:|||.|..||:||:..:|
Human   342 YCVSGLPISLPN-HAKNCVKMGLDMCEAIK--KVRDATGVDINMRVGVHSGNVLCGVIGLQKWQY 403

  Fly  1039 CLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQR---------- 1093
            .::...|..|:.||:.|||.::|.|   ...|:.|.|.:..|      :|.||.|          
Human   404 DVWSHDVTLANHMEAGGVPGRVHIS---SVTLEHLNGAYKVE------EGDGDIRDPYLKQHLVK 459

  Fly  1094 TYWLLGEDEEART-------RRTYERSQRRGSRALNKFIQ--GTIK------QAQEQANEYGIRS 1143
            ||:::....|.|:       |.|.:.::.|.|..:.::::  |..|      .......|.|..|
Human   460 TYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKIS 524

  Fly  1144 S----LKQKNLPRNSLTRSSSLESPKKLRF 1169
            :    :.|.|....:|...|     :|.||
Human   525 TTDVPMGQHNFQNRTLRTKS-----QKKRF 549

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10738NP_729905.2 PBP1_Speract_GC_like 41..441 CDD:107365
ANF_receptor 67..416 CDD:279440
PK_GC-A_B 570..853 CDD:270944
TyrKc 597..847 CDD:197581
HNOBA <862..907 CDD:285003 11/43 (26%)
CYCc 886..1078 CDD:214485 66/210 (31%)
Guanylate_cyc 913..1099 CDD:278633 63/195 (32%)
ADCY2NP_065433.2 AC_N <33..260 CDD:292831 12/47 (26%)
CYCc 236..439 CDD:214485 66/208 (32%)
Guanylate_cyc 281..465 CDD:278633 63/195 (32%)
DUF1053 495..599 CDD:283888 12/60 (20%)
CYCc 848..1056 CDD:214485
Guanylate_cyc 878..1077 CDD:278633
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 905..922
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 990..993
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.