DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10738 and gucy1b1

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_004911214.1	Gene:	gucy1b1 / 100379900	XenbaseID:	XB-GENE-950986	Length:	618	Species:	Xenopus tropicalis

Alignment Length:	687	Identity:	174/687 - (25%)
Similarity:	266/687 - (38%)	Gaps:	165/687 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   509 VSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTS 573
            :.|::.||:..|      :|:...:|.|:     :::.|...|.:.:       ...|:.|:..:
Frog     9 LELLVIRNYGPE------VWEDIKKEAQL-----DEEGQFLVRIIYD-------DSKTYDLVSAA 55

  Fly   574 QVSLSSNPD--------------ADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKL 624
            ...|:.|..              .:..|.||...:|                 ...||..:.|
Frog    56 TKVLNLNAGDILQMFGNMFFVFCQESGYDTILRVLG-----------------SNVREFLQNL-- 101

  Fly   625 LRDARHDNICAFIGACTDPPNIC---------IISEYCTRGSLKDILENEDVKLDNMFIASMVAD 680
              ||.||::.........|...|         |:..|..|..|:||:         :.|...||.
Frog   102 --DALHDHLGTIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIV---------IGIVKTVAQ 155

  Fly   681 IIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMS-------- 737
            .|.|. .:....|:.....|.....:......:..||  :..:...|::.|....:|
Frog   156 QIHGT-EIDMKVIQQRNEECDHTQFLIEEKDTREEDF--YEDQDRFEENGTQESRISPYTFCKAF 217

  Fly   738 ------------AKCLKLLYRAPELLRQGPSSL--VMGTQRG--DAYSFGIL--LYEMHVRRGPF 784
                        .:|...:||....|:.|..:|  |....|.  |....|||  :..:.|.|...
Frog   218 PFHIMFDRDLFVTQCGNAIYRVLPQLQPGNCNLLSVFSLVRPHIDISFHGILSHINTVFVLRSKE 282

  Fly   785 G-----------ETGLTPMQCL----QKVLQPQ--DYLNPYRPSLQPLETAFDCVSECLRECWAE 832
            |           |...|.:.||    |.:..|:  :.|....||:..|:..            ..
Frog   283 GLLDVEKSESEDELTGTEISCLRLKGQMIYLPEADNILFLCSPSVMNLDDL------------TR 335

  Fly   833 RPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMME-KYANNLEALVDDRTDQLQ-------EEKK 889
            |.....|.        ||....|..:........| |....||.|    ||:||       :|||
Frog   336 RGLYLSDI--------PLHDATRDLVLLGEQFREEYKLTQELEIL----TDRLQHTLRALEDEKK 388

  Fly   890 KTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECT----PLQVVDFLNDL 950
            |||.||:.:||..||::|:....|..:.|:.|:|.||.||||....::..    .:::|:.|||:
Frog   389 KTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNTFCSKHASGEGAMKIVNLLNDI 453

  Fly   951 YTCFDSIIGHYD---VYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPT 1012
            ||.||.:....:   ||||||:||.||.|||:| .....||..|..::|.::....:.::   ..
Frog   454 YTRFDILTDSRNNPYVYKVETVGDKYMTVSGIP-EPCVHHARSICHLALDMMEIAGQVQV---DG 514

  Fly  1013 NRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCS---WQCRQLLDRLG 1074
            ..:.:.||||:|.|..||:|.:||||||||:|||..||.|::|...||:.|   ::|....:...
Frog   515 ESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSD 579

  Fly  1075 -GYHFAERGVISMKGKGDQRTYWLLGEDEEARTRRTY 1110
             .:|...||.:|||||.|....|.|.. :.|.|..:|
Frog   580 PQFHLQYRGPVSMKGKTDPMQVWFLSR-KAAETEVSY 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944	62/348 (18%)
		TyrKc	597..847	CDD:197581	54/301 (18%)
		HNOBA	<862..907	CDD:285003	21/52 (40%)
		CYCc	886..1078	CDD:214485	77/202 (38%)
		Guanylate_cyc	913..1099	CDD:278633	74/196 (38%)
gucy1b1	XP_004911214.1	HNOB	2..166	CDD:377902	37/205 (18%)
		HNOBA	207..406	CDD:369471	52/222 (23%)
		Guanylate_cyc	412..605	CDD:306677	74/196 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910