DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and gucy2g

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_009305067.2	Gene:	gucy2g / 100333350	ZFINID:	ZDB-GENE-130531-70	Length:	1127	Species:	Danio rerio

Alignment Length:	1238	Identity:	414/1238 - (33%)
Similarity:	607/1238 - (49%)	Gaps:	212/1238 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AGNYHSGLLHPLLLLLFLLAFSN---------FRPTHGEVFTLGYLTASQRRPGNLDYNRPGLTI 65
            :|...|....|:...|...||:|         |:           ||...:.|.|:.|....|.:
Zfish     2 SGGLASDTSRPIRWWLLFTAFTNSVICNKDGQFK-----------LTVGLQAPRNISYPFSLLRL 55

  Fly    66 SGAISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQ-TAALWTQQVAAYIGPQETCVHE-- 127
            ..|:.:|::::|:........:..||..:|......|:|. ...:..|.|:|..||  .|..|
Zfish    56 GSAMQIAMDKINSNPALSGNFTFDFVYMDTDCNAKTSLRGFIEQVMEQNVSALFGP--PCPEEAE 118

  Fly   128 --GRMAAAFNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDD 190
              |.:|:.:|:||..:........|...:.|:.:..||..::.:.::..|..|.|..|..:
Zfish   119 VTGLIASTWNIPMFGFVGQTPKMDNIQVYDTYIKIVPPLKRVGEILLKALEFFGWKHVGMI---- 179

  Fly   191 ASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEAL-------------------- 235
            ..|                    .|..||:::          |||
Zfish   180 GGG--------------------ADANTWDSV----------EALWKSVDQQLRSKVTVTMGIKF 214

  Fly   236 ----VEQTYAN-------TRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPE 289
                :||...|       .|:.::|.:..:...:|:..|:.|::| |:|  |.:.::|::.:...
Zfish   215 DTSDLEQAKRNLQIISKVARVVVVLANAEDSTAMMIEAQKLGLMS-GEY--VFLLVQQFEVSGKV 276

  Fly   290 KYL--------RGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKYMERPPFNFPNPLGP 346
            ..|        ...:|:..:.:.|.|.:||.|      ..:..|.::....::..|| :.|
Zfish   277 DNLWKTSVSETNRTMLKAFDMVFVLAEKSYDG------YDYYDFFDQAYDKLKGDPF-YSN---- 330

  Fly   347 FGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIK---GSRYRSAMGYHVYIDE 408
            ...||::|:.||||:|||.|||..|.|...||...|:|..||..::   ..|:..|.|. |:.||
Zfish   331 LSSVKEVSSYAAYLHDAVLLYAMGLKEAFKSGKDIRHGREIVQKLRDRTSIRFYGASGL-VHFDE 394

  Fly   409 NGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTR 473
            .|:...:|              :|..|:...|.|...|.|...|.....:....||.|.|..|..
Zfish   395 YGERNLDY--------------SVYDLQQTETLIQFVSVLDFDSHTKMIKPTLRFSNIVWQNGKP 445

  Fly   474 PAAAPRCGFGGEKCVNYTGEISAAIAGGALLLL-----SLVSLVLYRNWRYEQELD-SLLWKIDF 532
            |...|.|||..|.|.....|||..:...||.|:     ||::|:..:..|.:..|| |..|.|::
Zfish   446 PTDNPSCGFDNELCEWLDNEISLLVLLVALPLIGVAAVSLITLLTLQKLRLQSRLDESNWWLINY 510

  Fly   533 REVQIHENEREQQSQKQTRHL-LNHLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGL 596
            .::.|      .:..|.|:.| :|..|.:.....       ||..|||| ..:.| ..|:..:||
Zfish   511 SDITI------LREPKGTQILSVNTTPSKCGSGG-------SQSMLSSN-SCNTR-EAIYATVGL 560

  Fly   597 YKGQLYAIKKVRKKSVDITREMKK-----ELKLLRDARHDNICAFIGACTDPPNICIISEYCTRG 656
            ::|....||.::.:   |..::||     |..:|::.:|:|:..|.|.|.||||:||:.:||.:|
Zfish   561 FQGNEVGIKYLKNQ---IIPDIKKPSIIAEFNMLKEMKHENLVQFFGVCIDPPNVCIVMQYCKKG 622

  Fly   657 SLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFA 721
            ||||:|.|.::.||.||..|...||:.|:.|:|.|.::.||.|..|.||||||..:||:.|||:.
Zfish   623 SLKDVLGNHEIDLDWMFKLSFAYDIVNGMEYIHKSSLKSHGNLRPSTCLVDSRLQIKLSGFGLWE 687

  Fly   722 FKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQ--GPSSLVMGTQRGDAYSFGILLYEM--HVRRG 782
            ||.|.:.....:.  |.|..::.:.|||.||:  .|.:   |||:||.|||.|::.|:  ....|
Zfish   688 FKCGTKHRLIPLD--SPKYEEMYWTAPEFLREIFYPFN---GTQKGDVYSFAIIIRELIYSTEVG 747

  Fly   783 PFGETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSE----CLRECWAERPEDRPDFKTI 843
            |:.:..|.|.:.::::..|... .|.||:|     :.|...|    .::.||:|.|:.||.|.:|
Zfish   748 PYHDVHLEPKEIIKQLRTPMSE-EPLRPTL-----SADICDERLIPLIKACWSENPDHRPPFGSI 806

  Fly   844 RTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLK 908
            |.:||........||.|||:..:|||||:||.:|::||.||..||.:.|.||..||||.:||||.
Zfish   807 RRQLRDACPESHANILDNMVNKLEKYANHLEEVVEERTSQLTVEKSRADKLLSSMLPRYIADQLM 871

  Fly   909 KGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAY 973
            .|..|:|..||.|:|:||||||||.|.:..:.|:||..|||||:.||.||..|||||||||||||
Zfish   872 AGKSVEPRSYEMVTIFFSDIVGFTTMCSVSSALEVVTLLNDLYSLFDDIIKLYDVYKVETIGDAY 936

  Fly   974 MVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRY 1038
            ||.||||:.||.|||.||:||:||.||::..|||||.|..||.|||||:||||.|||||..||||
Zfish   937 MVASGLPISNGTLHAEEISTMALHFLSSIKRFKIRHLPNERLALRIGINSGPVVAGVVGSTMPRY 1001

  Fly  1039 CLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLL----- 1098
            |||||||||||||||:.:|||||.|.....:|..:|.:...|||.|.:||||.|:|:|||
Zfish  1002 CLFGDTVNTASRMESNSLPLKIHISQSTADILLTIGTFELEERGDIEIKGKGTQKTFWLLSKPGF 1066

  Fly  1099 -----GEDEEARTRRTYERSQRRGSRALNKFIQGTIKQAQEQANEYGIRSSLKQKNLPRNSLTRS 1158
                 |:|...        |.:.|:.:.:      |||.:.:|...|   ..|:    |.::.|:
Zfish  1067 TFPPTGQDSNP--------SPKSGTDSCH------IKQEKTKAANDG---DFKE----RRTIQRT 1110

  Fly  1159 SSL 1161
            |::
Zfish  1111 SAM 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	96/446 (22%)
		ANF_receptor	67..416	CDD:279440	87/395 (22%)
		PK_GC-A_B	570..853	CDD:270944	107/295 (36%)
		TyrKc	597..847	CDD:197581	95/262 (36%)
		HNOBA	<862..907	CDD:285003	24/44 (55%)
		CYCc	886..1078	CDD:214485	122/191 (64%)
		Guanylate_cyc	913..1099	CDD:278633	121/195 (62%)
gucy2g	XP_009305067.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	1	1.100	-	-	LDO	PTHR11920
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7845
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.810