Protein Alignment CG10738 and gucy2g

DIOPT Version :10

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: XP_009305067.2
• Gene: gucy2g / 100333350
• ZFINID: ZDB-GENE-130531-70
• Length: 1127
• Species: Danio rerio
• Alignment Length: 1238
• Identity: 414/1238 - (33%)
• Similarity: 607/1238 - (49%)
• Gaps: 212/1238 - (17%)

  Fly    10 AGNYHSGLLHPLLLLLFLLAFSN---------FRPTHGEVFTLGYLTASQRRPGNLDYNRPGLTI 65
            :|...|....|:...|...||:|         |:           ||...:.|.|:.|....|.:
Zfish     2 SGGLASDTSRPIRWWLLFTAFTNSVICNKDGQFK-----------LTVGLQAPRNISYPFSLLRL 55

  Fly    66 SGAISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQ-TAALWTQQVAAYIGPQETCVHE-- 127
            ..|:.:|::::|:........:..||..:|......|:|. ...:..|.|:|..||  .|..|
Zfish    56 GSAMQIAMDKINSNPALSGNFTFDFVYMDTDCNAKTSLRGFIEQVMEQNVSALFGP--PCPEEAE 118

  Fly   128 --GRMAAAFNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDD 190
              |.:|:.:|:||..:........|...:.|:.:..||..::.:.::..|..|.|..|..:
Zfish   119 VTGLIASTWNIPMFGFVGQTPKMDNIQVYDTYIKIVPPLKRVGEILLKALEFFGWKHVGMI---- 179

  Fly   191 ASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEAL-------------------- 235
            ..|                    .|..||:::          |||
Zfish   180 GGG--------------------ADANTWDSV----------EALWKSVDQQLRSKVTVTMGIKF 214

  Fly   236 ----VEQTYAN-------TRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPE 289
                :||...|       .|:.::|.:..:...:|:..|:.|::| |:|  |.:.::|::.:...
Zfish   215 DTSDLEQAKRNLQIISKVARVVVVLANAEDSTAMMIEAQKLGLMS-GEY--VFLLVQQFEVSGKV 276

  Fly   290 KYL--------RGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKYMERPPFNFPNPLGP 346
            ..|        ...:|:..:.:.|.|.:||.|      ..:..|.::....::..|| :.|
Zfish   277 DNLWKTSVSETNRTMLKAFDMVFVLAEKSYDG------YDYYDFFDQAYDKLKGDPF-YSN---- 330

  Fly   347 FGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIK---GSRYRSAMGYHVYIDE 408
            ...||::|:.||||:|||.|||..|.|...||...|:|..||..::   ..|:..|.|. |:.||
Zfish   331 LSSVKEVSSYAAYLHDAVLLYAMGLKEAFKSGKDIRHGREIVQKLRDRTSIRFYGASGL-VHFDE 394

  Fly   409 NGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTR 473
            .|:...:|              :|..|:...|.|...|.|...|.....:....||.|.|..|..
Zfish   395 YGERNLDY--------------SVYDLQQTETLIQFVSVLDFDSHTKMIKPTLRFSNIVWQNGKP 445

  Fly   474 PAAAPRCGFGGEKCVNYTGEISAAIAGGALLLL-----SLVSLVLYRNWRYEQELD-SLLWKIDF 532
            |...|.|||..|.|.....|||..:...||.|:     ||::|:..:..|.:..|| |..|.|::
Zfish   446 PTDNPSCGFDNELCEWLDNEISLLVLLVALPLIGVAAVSLITLLTLQKLRLQSRLDESNWWLINY 510

  Fly   533 REVQIHENEREQQSQKQTRHL-LNHLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGL 596
            .::.|      .:..|.|:.| :|..|.:.....       ||..|||| ..:.| ..|:..:||
Zfish   511 SDITI------LREPKGTQILSVNTTPSKCGSGG-------SQSMLSSN-SCNTR-EAIYATVGL 560

  Fly   597 YKGQLYAIKKVRKKSVDITREMKK-----ELKLLRDARHDNICAFIGACTDPPNICIISEYCTRG 656
            ::|....||.::.:   |..::||     |..:|::.:|:|:..|.|.|.||||:||:.:||.:|
Zfish   561 FQGNEVGIKYLKNQ---IIPDIKKPSIIAEFNMLKEMKHENLVQFFGVCIDPPNVCIVMQYCKKG 622

  Fly   657 SLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFA 721
            ||||:|.|.::.||.||..|...||:.|:.|:|.|.::.||.|..|.||||||..:||:.|||:.
Zfish   623 SLKDVLGNHEIDLDWMFKLSFAYDIVNGMEYIHKSSLKSHGNLRPSTCLVDSRLQIKLSGFGLWE 687

  Fly   722 FKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQ--GPSSLVMGTQRGDAYSFGILLYEM--HVRRG 782
            ||.|.:.....:.  |.|..::.:.|||.||:  .|.:   |||:||.|||.|::.|:  ....|
Zfish   688 FKCGTKHRLIPLD--SPKYEEMYWTAPEFLREIFYPFN---GTQKGDVYSFAIIIRELIYSTEVG 747

  Fly   783 PFGETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSE----CLRECWAERPEDRPDFKTI 843
            |:.:..|.|.:.::::..|... .|.||:|     :.|...|    .::.||:|.|:.||.|.:|
Zfish   748 PYHDVHLEPKEIIKQLRTPMSE-EPLRPTL-----SADICDERLIPLIKACWSENPDHRPPFGSI 806

  Fly   844 RTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLK 908
            |.:||........||.|||:..:|||||:||.:|::||.||..||.:.|.||..||||.:||||.
Zfish   807 RRQLRDACPESHANILDNMVNKLEKYANHLEEVVEERTSQLTVEKSRADKLLSSMLPRYIADQLM 871

  Fly   909 KGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAY 973
            .|..|:|..||.|:|:||||||||.|.:..:.|:||..|||||:.||.||..|||||||||||||
Zfish   872 AGKSVEPRSYEMVTIFFSDIVGFTTMCSVSSALEVVTLLNDLYSLFDDIIKLYDVYKVETIGDAY 936

  Fly   974 MVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRY 1038
            ||.||||:.||.|||.||:||:||.||::..|||||.|..||.|||||:||||.|||||..||||
Zfish   937 MVASGLPISNGTLHAEEISTMALHFLSSIKRFKIRHLPNERLALRIGINSGPVVAGVVGSTMPRY 1001

  Fly  1039 CLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLL----- 1098
            |||||||||||||||:.:|||||.|.....:|..:|.:...|||.|.:||||.|:|:|||
Zfish  1002 CLFGDTVNTASRMESNSLPLKIHISQSTADILLTIGTFELEERGDIEIKGKGTQKTFWLLSKPGF 1066

  Fly  1099 -----GEDEEARTRRTYERSQRRGSRALNKFIQGTIKQAQEQANEYGIRSSLKQKNLPRNSLTRS 1158
                 |:|...        |.:.|:.:.:      |||.:.:|...|   ..|:    |.::.|:
Zfish  1067 TFPPTGQDSNP--------SPKSGTDSCH------IKQEKTKAANDG---DFKE----RRTIQRT 1110

  Fly  1159 SSL 1161
            |::
Zfish  1111 SAM 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_SAP_GC-like	41..441	CDD:380593	96/446 (22%)
		PK_GC-A_B	570..853	CDD:270944	107/295 (36%)
		HNOBA	<860..907	CDD:462234	26/46 (57%)
		CYCc	886..1078	CDD:214485	122/191 (64%)
gucy2g	XP_009305067.2	Periplasmic_Binding_Protein_type1	37..430	CDD:471960	100/457 (22%)
		Protein Kinases, catalytic domain	535..811	CDD:473864	105/298 (35%)
		HNOBA	<816..870	CDD:462234	28/53 (53%)
		CYCc	850..1041	CDD:214485	122/190 (64%)