DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10738 and gucy1b1

DIOPT Version :9

Sequence 1:NP_729905.2 Gene:CG10738 / 39516 FlyBaseID:FBgn0036368 Length:1250 Species:Drosophila melanogaster
Sequence 2:NP_001238874.1 Gene:gucy1b1 / 100150304 ZFINID:ZDB-GENE-090313-160 Length:608 Species:Danio rerio


Alignment Length:559 Identity:165/559 - (29%)
Similarity:235/559 - (42%) Gaps:125/559 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   616 REMKKELKLLRDARHDNICAFIGA-------CTDPP--NICIISEYCTRGSLKDILENEDVKLDN 671
            ||..:.|    ||.||::......       |||..  |..|:..|..|..|:||          
Zfish    95 REFLQNL----DALHDHLGTIYPGMRAPSFRCTDAEKGNNLILHYYSEREGLQDI---------- 145

  Fly   672 MFIASMVADIIRGVI-YLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQ---GIEDSST- 731
                  |..||:.|. .:|.:.|........|......:::::..|....||.:   |.|::.| 
Zfish   146 ------VIGIIKTVAQQIHGTEIEMKVIQPKSEECDHIKFLIEEKDSEEEAFYEDLDGFEENGTQ 204

  Fly   732 -------------------DMQHMSAKCLKLLYRAPELLRQGPSSL--VMGTQRGDA-YSF-GIL 773
                               |...|..:|...::|....|:.|..:|  |....|... :|| |||
Zfish   205 ETRISPYTFCKAFPFHLMFDKDLMLTQCGNAIFRVLPQLQPGVCNLSSVFSLVRPHIDFSFHGIL 269

  Fly   774 --LYEMHVRRGPFG-----------ETGLTPMQCL----QKVLQP--QDYLNPYRPSLQPLETAF 819
              :..:.|.|...|           |...|.:.||    |.:..|  ::.|....||:..|:.. 
Zfish   270 SHINTVFVLRSKEGLLNVETAENEDELTGTEISCLRLKGQMISLPETENILFLCSPSVMNLDDL- 333

  Fly   820 DCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMME-KYANNLEALVDDRTDQ 883
                       ..|.....|.        ||....|..:........| |....||.|    ||:
Zfish   334 -----------TRRGLYLSDI--------PLHDATRDLVLLGEQFREEYKLTQELEIL----TDR 375

  Fly   884 LQ-------EEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAM-----SA 936
            ||       :||||||.||:.:||..||::|:....|..:.|:.|:|.||.||||.|.     ||
Zfish   376 LQHTLRALEDEKKKTDRLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASA 440

  Fly   937 ECTPLQVVDFLNDLYTCFDSIIGHYD---VYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHL 998
            | ..:::|:.|||:||.||.:.....   ||||||:||.||.||||| .....||..|..::|.:
Zfish   441 E-GAIKIVNLLNDIYTRFDILTDSRKNPYVYKVETVGDKYMTVSGLP-EPCTHHAKSICHLALDM 503

  Fly   999 LSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCS 1063
            :....:.|:...|..   :.||||:|.|..||:|.:||||||||:|||..||.|::|...||:.|
Zfish   504 MEIAGQVKVDEDPVQ---ITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVS 565

  Fly  1064 ---WQCRQLLDRLG-GYHFAERGVISMKGKGDQRTYWLL 1098
               ::|.|.::... .:|...||.::||||.:....|.|
Zfish   566 EYTYRCLQSVENADPQFHLEYRGPVTMKGKKEPMKVWFL 604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10738NP_729905.2 PBP1_Speract_GC_like 41..441 CDD:107365
ANF_receptor 67..416 CDD:279440
PK_GC-A_B 570..853 CDD:270944 61/292 (21%)
TyrKc 597..847 CDD:197581 59/286 (21%)
HNOBA <862..907 CDD:285003 21/52 (40%)
CYCc 886..1078 CDD:214485 85/203 (42%)
Guanylate_cyc 913..1099 CDD:278633 81/198 (41%)
gucy1b1NP_001238874.1 HNOB 2..166 CDD:285002 23/90 (26%)
HNOBA 207..406 CDD:285003 53/222 (24%)
CYCc 385..584 CDD:214485 85/203 (42%)
Guanylate_cyc 412..605 CDD:278633 81/198 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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