DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10116 and LPL

DIOPT Version :10

Sequence 1:NP_648652.1 Gene:CG10116 / 39515 FlyBaseID:FBgn0036367 Length:289 Species:Drosophila melanogaster
Sequence 2:NP_000228.1 Gene:LPL / 4023 HGNCID:6677 Length:475 Species:Homo sapiens


Alignment Length:311 Identity:88/311 - (28%)
Similarity:144/311 - (46%) Gaps:62/311 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 ETGFFLNTRR--VQENAQPIEAEVEALVRSSFYAADPTVVTIPRW-LGNISSPEIPAVVSARLQQ 82
            |:.|.|.|..  .::....|....|::....|..:..|.:.|..| :..:....:|.:|:|..::
Human    38 ESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKR 102

  Fly    83 Q-DSNIISVD-LSEANDE-------TEII-DSVASLVIVLHNQFDMPLDRILVVGFAEGAHLAGG 137
            : |||:|.|| ||.|.:.       |::: ..||..:..:..:|:.|||.:.::|::.||| |.|
Human   103 EPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAH-AAG 166

  Fly   138 VAAKVQQDLGRQLSQITALDPSSG----AELDHKLSQADAEFVEVVHTNAGGE-----GTWERLG 193
            :|..:   ..:::::||.|||:..    ||...:||..||:||:|:||...|.     |..:.:|
Human   167 IAGSL---TNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVG 228

  Fly   194 HVDYYPNGGQTQPGCTTD------------------SCSHERAFELLAE-MWSPENDFVSARCGS 239
            |||.|||||..||||...                  .|||||:..|..: :.:.||...:.||.|
Human   229 HVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSS 293

  Fly   240 VETLSAS---SCR--------WSTHKMGQKQEEEQPASGIYFLETRQSSPF 279
            .|.....   |||        :..:|:..|:..:.      :|:||...|:
Human   294 KEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKM------YLKTRSQMPY 338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10116NP_648652.1 alpha/beta hydrolases 24..274 CDD:473884 84/301 (28%)
LPLNP_000228.1 Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:30559189 32..53 4/14 (29%)
lipo_lipase 33..473 CDD:132274 88/311 (28%)
Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706 243..266 1/22 (5%)
Important for interaction with lipoprotein particles. /evidence=ECO:0000269|PubMed:27929370 417..421
Important for heparin binding. /evidence=ECO:0000269|PubMed:11342582 430..434
Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:26725083, ECO:0000269|PubMed:30559189 443..467
Blue background indicates that the domain is not in the aligned region.

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