DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10116 and LPL

DIOPT Version :9

Sequence 1:NP_648652.1 Gene:CG10116 / 39515 FlyBaseID:FBgn0036367 Length:289 Species:Drosophila melanogaster
Sequence 2:NP_000228.1 Gene:LPL / 4023 HGNCID:6677 Length:475 Species:Homo sapiens


Alignment Length:311 Identity:88/311 - (28%)
Similarity:144/311 - (46%) Gaps:62/311 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 ETGFFLNTRR--VQENAQPIEAEVEALVRSSFYAADPTVVTIPRW-LGNISSPEIPAVVSARLQQ 82
            |:.|.|.|..  .::....|....|::....|..:..|.:.|..| :..:....:|.:|:|..::
Human    38 ESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKR 102

  Fly    83 Q-DSNIISVD-LSEANDE-------TEII-DSVASLVIVLHNQFDMPLDRILVVGFAEGAHLAGG 137
            : |||:|.|| ||.|.:.       |::: ..||..:..:..:|:.|||.:.::|::.||| |.|
Human   103 EPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAH-AAG 166

  Fly   138 VAAKVQQDLGRQLSQITALDPSSG----AELDHKLSQADAEFVEVVHTNAGGE-----GTWERLG 193
            :|..:   ..:::::||.|||:..    ||...:||..||:||:|:||...|.     |..:.:|
Human   167 IAGSL---TNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVG 228

  Fly   194 HVDYYPNGGQTQPGCTTD------------------SCSHERAFELLAE-MWSPENDFVSARCGS 239
            |||.|||||..||||...                  .|||||:..|..: :.:.||...:.||.|
Human   229 HVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSS 293

  Fly   240 VETLSAS---SCR--------WSTHKMGQKQEEEQPASGIYFLETRQSSPF 279
            .|.....   |||        :..:|:..|:..:.      :|:||...|:
Human   294 KEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKM------YLKTRSQMPY 338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10116NP_648652.1 Abhydrolase 24..274 CDD:304388 84/301 (28%)
LPLNP_000228.1 Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:30559189 32..53 4/14 (29%)
Lipase 33..473 CDD:332983 88/311 (28%)
Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706 243..266 1/22 (5%)
Important for interaction with lipoprotein particles. /evidence=ECO:0000269|PubMed:27929370 417..421
Important for heparin binding. /evidence=ECO:0000269|PubMed:11342582 430..434
Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:26725083, ECO:0000269|PubMed:30559189 443..467
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11610
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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