DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10116 and Lpl

DIOPT Version :9

Sequence 1:NP_648652.1 Gene:CG10116 / 39515 FlyBaseID:FBgn0036367 Length:289 Species:Drosophila melanogaster
Sequence 2:NP_036730.1 Gene:Lpl / 24539 RGDID:3017 Length:474 Species:Rattus norvegicus


Alignment Length:340 Identity:97/340 - (28%)
Similarity:155/340 - (45%) Gaps:75/340 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 VQLALFL-TLT-----IAAVYG-------ETGFFLNTRR--VQENAQPIEAEVEALVRSSFYAAD 54
            |.|.::| :||     :||..|       |:.|.|.|..  .::....|....:::....|..:.
  Rat     9 VALGVWLQSLTAFRGGVAAADGGRDFSDIESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSS 73

  Fly    55 PTVVTIPRW-LGNISSPEIPAVVSARLQQQ-DSNIISVD-LSEANDE-------TEII-DSVASL 108
            .|.|.|..| :..:....:|.:|:|..::: |||:|.|| |..|...       |::: :.||..
  Rat    74 KTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARF 138

  Fly   109 VIVLHNQFDMPLDRILVVGFAEGAHLAGGVAAKVQQDLGRQLSQITALDPSSG----AELDHKLS 169
            :..|..:|:.|||.:.::|::.||| |.|||..:   ..:::::||.|||:..    ||...:||
  Rat   139 INWLEEEFNYPLDNVHLLGYSLGAH-AAGVAGSL---TNKKVNRITGLDPAGPNFEYAEAPSRLS 199

  Fly   170 QADAEFVEVVHTNAGGE-----GTWERLGHVDYYPNGGQTQPGCTTD------------------ 211
            ..||:||:|:||...|.     |..:.:||||.|||||..||||...                  
  Rat   200 PDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAEKGLGDVDQLV 264

  Fly   212 SCSHERAFELLAE-MWSPENDFVSARCGSVETLSAS---SCR--------WSTHKMGQKQEEEQP 264
            .|||||:..|..: :.:.||...:.||.|.|.....   |||        :..:|:..|:..:. 
  Rat   265 KCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNVGYEINKVRAKRSSKM- 328

  Fly   265 ASGIYFLETRQSSPF 279
                 :|:||...|:
  Rat   329 -----YLKTRSQMPY 338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10116NP_648652.1 Abhydrolase 24..274 CDD:304388 85/301 (28%)
LplNP_036730.1 Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 32..53 4/20 (20%)
lipo_lipase 33..472 CDD:132274 89/316 (28%)
Pancreat_lipase_like 37..334 CDD:238363 87/306 (28%)
Essential for determining substrate specificity. /evidence=ECO:0000250|UniProtKB:P06858 243..266 1/22 (5%)
PLAT_LPL 341..465 CDD:238856
Important for interaction with lipoprotein particles. /evidence=ECO:0000250|UniProtKB:P06858 417..421
Important for heparin binding. /evidence=ECO:0000250|UniProtKB:P06858 430..434
Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 443..467
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11610
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.010

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