Protein Alignment cmb and PCM1

DIOPT Version :9

• Sequence 1: NP_729901.1
• Gene: cmb / 39513
• FlyBaseID: FBgn0036365
• Length: 1657
• Species: Drosophila melanogaster
• Sequence 2: XP_011542830.1
• Gene: PCM1 / 5108
• HGNCID: 8727
• Length: 2157
• Species: Homo sapiens
• Alignment Length: 2119
• Identity: 390/2119 - (18%)
• Similarity: 674/2119 - (31%)
• Gaps: 771/2119 - (36%)

  Fly     9 VDQANASARSNGSSNNNSVGGATGAVPKQQTPVNGAPTSGSSASVTSSRS---ARSRRQQEHLGE 70
            ::.::...||.||   :|.|.||.|..|:|...|..|.:.....:.:::|   :.:...:|.:|.
Human   107 INFSDLDQRSIGS---DSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTNPPNRETIGS 168

  Fly    71 PDMELVEPETLQRETLKTLNDLLQRARITNAKNR-SPAEQH-------LSSKDHRSPAQQQQQRE 127
            ...:.:....|.       |||||..:::....| .||.:.       :..:|:.:.|  ...||
Human   169 AQCKELFASALS-------NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKA--SSMRE 224

  Fly   128 ALRQLAAEHGNYD----TAEQLQEQQQRY-RFPVRPVQRVQHQPS----SSANSTGAPSSSTAL- 182
            .|.:......|.:    ..:.|:||::.| :|..:.:.|...:..    .||..:|:.:.||:|
Human   225 DLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARENEEEDVRTIDSAVGSGSVAESTSLN 289

  Fly   183 -----------------LRLRQ-------STPPNATVGVVIPNATTS-NGNGNLSGNEEQAPPLT 222
                             ||:|.       ::.....|..:  :.||| .|.|:...|:.:..|
Human   290 IDVQSEASDTTEEASFSLRIRPCIEDKLGNSASQEQVSDI--DVTTSPKGKGDRPQNDRELRP-- 350

  Fly   223 PAGLQQLVHRLLGVHHFAP------------RTEGFRSQVDVLRALLGLDENLNSRYQPSRKVVE 275
                    :|........|            ..|..:.|.|:|:.:|...|.|.:.......::.
Human   351 --------NRKYSQKRGFPSKARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLA 407

  Fly   276 TNNMVHEINPNSDQGEGVVNSTSLEDVAL-SEMSDNRAQSIQSLHSVLETPTPDTTP----SFDE 335
            ..:...:.....|.......:.||..|:: ||:::.....||..|:.|....|...|    ..:.
Human   408 LQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAES 472

  Fly   336 LQQRLEASNRN----MQHLHDEQAKLLQIQNLAKTHLNEMERLRQQADSL--PHNVNGGEAPKYE 394
            |....|.|...    .:.|.||:.:|.....:.:....:|::|..:..:|  .|..|...:|: .
Human   473 LSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQ-R 536

  Fly   395 SVQQ---------------VQDDMASLVGRMKNLTAFIHNQNELSTVLGDDGPEILAEQEALQEK 444
            ||.|               |..:..||...:...||.:.:|||      .:....|...|.|| |
Human   537 SVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNE------SENEGHLNPSEKLQ-K 594

  Fly   445 LESLRTQREDMRNLVDELNSINRAARETARVIKEKEETPTPPPKPEEAAPAAPKERVVPVEYQRN 509
            |..:|.:..::|.||......:....:.....::.|||       ||:...:..|...||...||
Human   595 LNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEET-------EESEYDSEHENSEPVTNIRN 652

  Fly   510 VPI--------------------------------------IR---------------------- 514
            ..:                                      ||
Human   653 PQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLADCRYNREGEQEIH 717

  Fly   515 ---------------QEAANAAQRALHAQAMINQKTADIE---------ALKAQMARLKGMLYTV 555
                           :|..:.|..:.|..:::::...|.|         |.|.::.:|:.::..|
Human   718 VAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMV 782

  Fly   556 --------------SQIEESTPSMGSTLERRSEERTSVERELPAEIAQRVFALNDVTSE------ 600
                          |.:::..|:...|.:..:..|.:..:      .|:...:|:...|
Human   783 QDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANK------TQKDTGVNEKAREKFYEAK 841

  Fly   601 ---LRAEAASLQKERDRILALKAEIERRK------QQAAAAVQMGDDALKR--SSLTPTPTPMRQ 654
               .:.|...||:||.:::.::.:|:..:      |.:||:|  |:...|:  .::|.||| :.|
Human   842 LQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASV--GNCPTKKYMPAVTSTPT-VNQ 903

  Fly   655 RMT-------EEEDPSEVDNSLQATPTK-EQLRDEL---RSQCERLRTEYEQK------------ 696
            ..|       |.||.|.|||.|.:...: |.||:||   |.|.|.|..|::::
Human   904 HETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAV 968

  Fly   697 --------------QRELEQRYVASNNTTSEADDEANDDTDSDKYFAN--VRTASSATLKRAPSA 745
                          |...|:.......:|..|.||..|:   |.|.:.  |||......::..|:
Human   969 SLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDEEGDE---DGYLSEGIVRTDEEEEEEQDASS 1030

  Fly   746 NTVVEQRRGQQPNVPPQQAPPPPPPAPPSTLNEDDLNVTLDTLSLGNDSIPSSSNRSQYMPPPMQ 810
            |                                |:.:|           .||:|
Human  1031 N--------------------------------DNFSV-----------CPSNS----------- 1041

  Fly   811 PVPGMWASHNS------GSSWHGQQPVYGQPSSSAGTEFKKLPAAQQGGSSNGSGSNASTDAVLL 869
                  .:|||      .:.|....|.      ||...::.|...:|...|
Human  1042 ------VNHNSYNGKETKNRWKNNCPF------SADENYRPLAKTRQQNIS-------------- 1080

  Fly   870 QQFMQTQQML-----INSVCQCNQALWHQQREIDNLNHQLHALQDRFNVVACQ-----DHSFGLR 924
               ||.|:.|     ::.|.:..|  |  |.:|:.|..||.     |:|..||     ..:....
Human  1081 ---MQRQENLRWVSELSYVEEKEQ--W--QEQINQLKKQLD-----FSVSICQTLMQDQQTLSCL 1133

  Fly   925 SESVPPPVGPGMGQMPNNLCLGSSRAQSEQLFNFGAHQS---------AFSNYQRSCHRSGAESH 980
            .:::  ..|| ...||:|:.       |.|: :|..||.         ..:|.||.  :......
Human  1134 LQTL--LTGP-YSVMPSNVA-------SPQV-HFIMHQLNQCYTQLTWQQNNVQRL--KQMLNEL 1185

  Fly   981 HHQQQQHQAQP----FLNNAAPPPPPTHFNNETPLSPPTYRSSPGPIFMNHHNNTIHQNNSNLRT 1041
            ..||.||..:|    ..::|:.||.|:.|   .|.|.||.     |:
Human  1186 MRQQNQHPEKPGGKERGSSASHPPSPSLF---CPFSFPTQ-----PV------------------ 1224

  Fly  1042 QNQHANNLHSLPEGAAGGGAPGGGITLNNQVPPG-NRANNYWDNFRSHSRQNLLSNKSNEELNVD 1105
                  ||.::|           |.|..:...|| |.:..:..||...| ||:
Human  1225 ------NLFNIP-----------GFTNFSSFAPGMNFSPLFPSNFGDFS-QNI------------ 1259

  Fly  1106 LQQYRRQRARPSYFQPPQLLPPTTRGGLTHQQQRRHFFEAPLTALHGSSSNGSNNLNNSGSSGRK 1170
                    :.||..|.|  |...:.|...:..     |..|   ...|||.|:....|
Human  1260 --------STPSEQQQP--LAQNSSGKTEYMA-----FPKP---FESSSSIGAEKPRN------- 1299

  Fly  1171 RDWRDDAGHIRDHDDEDVD------------EVEE-----------------NHDNVIFGSGRRR 1206
                      :...:|:|:            |||:                 |..|.:..:||||
Human  1300 ----------KKLPEEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRR 1354

  Fly  1207 NRRRPQLSTLRDDESEQASSSNLNMNVNYGNSPLYQRNKVPAKPTTSTVSLTPLQQRHLRFDFEL 1271
            .         .|:||.::.||..:.......:..::..|..|:.:.::...||..:...|...:|
Human  1355 Q---------FDEESLESFSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQL 1410

  Fly  1272 PAHYMDYIELPQITPVDTTPTLGQEASPADESNA-MEQTEETASEEL----NRNLLVNALKNDKF 1331
            .:...:.| :...|....:.::.....|....|. ..||||....::    |...|...:|.::.
Human  1411 KSRVKNII-VTFFTQGYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRS 1474

  Fly  1332 TT----------------------------KFYESIKEDVYRRLETLFEQQQQQ----------- 1357
            |.                            ..:|::::.:|..:.||..|.:.:
Human  1475 TEISSAHARRILQQSNRNACNEAPETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHEL 1539

  Fly  1358 --------QQQ-----QQQQNQQLQHSHEPHGLRKALNQ------------EENEPTGDAEATES 1397
                    :|:     |...::.:..|||.....|::|.            .|:..|.|.|..|.
Human  1540 QLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEK 1604

  Fly  1398 RSETPLEVMRLQLDNDRPE-------------DEKGTPVKQLSLSNPQNGQHLDEMEDSASAVIS 1449
            ..|.....:..|.|.|...             |:.|..|..|.       |.|..|.:     ..
Human  1605 NFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLD-------QALARMRE-----YE 1657

  Fly  1450 SLRTENEE--------QILEGKLEQASGSGSGPGTSI---ELAP--------------------- 1482
            .::||.|.        :|:|      .|.|:|.||::   |..|
Human  1658 RMKTEAESNSNMRCTCRIIE------DGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPR 1716

  Fly  1483 -DHELIEYIIKRIR----------NQTHNNTVINDSLLAEVSKLTATAAQNSTASSPLIS----- 1531
             |.:.::..||.|.          :|.|.:.|.:..||..|.::..|..|.:..|...:.
Human  1717 IDTQQLDRQIKAIMKEVIPFLKDFSQEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQ 1781

  Fly  1532 ---------PKRIYAKIKKM--DIPRQRDEFL---LWYRSYLEQL----FVVEQPQDSCKTKSKV 1578
                     .|....|:|..  |:..:..|.|   |.:...::.|    ..|:|   .||.|.:.
Human  1782 LGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQ---RCKRKIEA 1843

  Fly  1579 T-------------------PSGASPAKLKN-------------------QRVRKQSQSQSQDSN 1605
            |                   |:|....:.|:                   :.||.....|.:|..
Human  1844 TGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEE 1908

  Fly  1606 NDA-----DLAEADQKNVSSAGNGELECENNENPDEEAD 1639
            ::.     :|::|:.:.:::.|:||     :||.|||.:
Human  1909 SEGCPVSINLSKAETQALTNYGSGE-----DENEDEEME 1942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmb	NP_729901.1	Smc	339..>720	CDD:224117	103/553 (19%)
PCM1	XP_011542830.1	PCM1_C	1501..2131	CDD:318018	84/468 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CMS0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900