Protein Alignment cmb and Pcm1

DIOPT Version :9

• Sequence 1: NP_729901.1
• Gene: cmb / 39513
• FlyBaseID: FBgn0036365
• Length: 1657
• Species: Drosophila melanogaster
• Sequence 2: XP_036009708.1
• Gene: Pcm1 / 18536
• MGIID: 1277958
• Length: 2071
• Species: Mus musculus
• Alignment Length: 2157
• Identity: 404/2157 - (18%)
• Similarity: 686/2157 - (31%)
• Gaps: 703/2157 - (32%)

  Fly     9 VDQANASARSNGSSNNNSVGGATGAVPKQQTPVNGAPTSGSSASVTSSRSARSRRQQEHLGEPDM 73
            ::.::...||.||   :|.|.||.|..|:|...|..|.:.....:.:::|     :......|..
Mouse   107 INFSDLDQRSIGS---DSQGRATAANNKRQLSENRKPFNFLPMQINTNKS-----KDATASLPKR 163

  Fly    74 ELVEPETLQRETLKTL-NDLLQRARITNAKNR-SPAEQH-------LSSKDHRSPAQQQQQREAL 129
            |:......:......| |||||..:::....| .||.:.       :..:|:.:.|  ...||.|
Mouse   164 EMTTSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKA--SSMREDL 226

  Fly   130 RQLAAEHGNYD----TAEQLQEQQQRY-RFPVRPVQRVQHQPS----SSANSTGAPSSSTALLRL 185
            .:......|.:    ..|.|:||::.| :|..:.:.|...:..    .||..:|:.:.||:|
Mouse   227 VEKNERSANVERLTHLIEHLKEQEKSYMKFLQKILARENEEEDVRTVDSAVGSGSVAESTSL--- 288

  Fly   186 RQSTPPNATVGVVIPNATTSNGNGNLSGNEEQAPPLTPAGLQQLVHRLLGVHHFAPRTEGFRSQV 250
                           ||...:...:.:..:.|..|:                   ..||..:.|.
Mouse   289 ---------------NADVQSEASDTTARDPQQEPM-------------------EETENLKKQH 319

  Fly   251 DVLRALLGLDENLNSRYQPSRKVVETNNMVHEINPNSDQGEGVVNST--SLEDVAL-SEMSDNRA 312
            |:|:.:|...|.|.:.......::...:...:.....|  :.||..|  ||..|:: ||:::...
Mouse   320 DLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMD--DSVVTETTGSLSGVSITSELNEELN 382

  Fly   313 QSIQSLHSVLETPTPDTTPSFDELQQ-------RLEASNRN---MQHLHDEQAKLL--------- 358
            ..||..|:.|....|...|  |..:|       |..:.:||   .:||.||:.:|.
Mouse   383 DLIQRFHNQLRDSQPPAVP--DNRRQAESLSLTREISQSRNPSVSEHLPDEKVQLFSKMRVLQEK 445

  Fly   359 ---------QIQNLAKTHLN--------EMER--------------------LRQQADSLPHNV- 385
                     ::.||...|||        .::|                    :..:|:||..:|
Mouse   446 KQKMDKLLGELHNLRDQHLNNSSFVPSTSLQRSGDKRSSTVALSAPVGFASAVNGEANSLISSVP 510

  Fly   386 -------------NGGE---APKYESVQQVQDDMASLVGRMKNLTAFIHNQNELSTVLGDDGPEI 434
                         |.|.   |.|.:.:.:||.       |:..|...:|...:.|.::.|...|.
Mouse   511 CPATSLVSQNESENEGHLNPAEKLQKLNEVQK-------RLNELRELVHYYEQTSDMMTDAVNEN 568

  Fly   435 LAEQEALQEKLESLRTQREDMRNL--------VDELN--------SINRAAR----------ETA 473
            ..::|..:.:.:|.....|.:.|:        .:|:|        |.||..|          .:|
Mouse   569 TKDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNTNSNTQCGSNNRDGRPVNSNCEINNRSA 633

  Fly   474 RVIKEKEETPTPPPKPEEAAPAAPKERVVPVEYQRNVPIIRQEAANAAQRALHAQAMINQKTAD- 537
            ..|:.....|.......|.     ::|:.....:.....:.:|..:.|..:....:::::...|
Mouse   634 ANIRALNMPPLDCRYNREG-----EQRLHVAHGEDEEEEVEEEGVSGASLSSRRSSLVDEAPEDE 693

  Fly   538 -----IEALKAQMARLKGMLYTVSQIEES------TPSMGS-----TLERRSEERTSVERELPAE 586
                 |..|.|...:||.:...|:.:::.      .|:..:     ..|...::.::..||...:
Mouse   694 EFEQKISRLMAAKEKLKQLQDLVAMVQDDDATQVVVPAASNLDDFYAAEEDIKQNSNNARENSNK 758

  Fly   587 IAQRVFALNDVTSE---------LRAEAASLQKERDRILALKAEIERRK------QQAAAAVQMG 636
            |...|   |:.|.|         .:.|...||:||.:::.::.:|:..:      |.:|.::..|
Mouse   759 IDTGV---NEKTREKFYEAKLQQQQRELKQLQEERKKLIEIQEKIQAVQKACPDLQLSATSISSG 820

  Fly   637 DDALKRSSLTPTPT------PMRQRMTEEEDPSEVDNSLQATPTK-EQLRDEL---RSQCERLRT 691
            .......::|.|||      ...:.:.:.||.|.|||.|.:...: |.||:||   |.|.|.|..
Mouse   821 PTKKYLPAITSTPTVNENDSSTSKCVIDPEDSSVVDNELWSDMRRHEMLREELRQRRKQLEALMA 885

  Fly   692 EYEQK--------------------------QRELEQRYVASNNTTSEADDEANDDTDSDKYFAN 730
            |::::                          |...|:.......:|..|.||..|:   |.|.:.
Mouse   886 EHQRRQGLAETSSPVAISLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDEEGDE---DGYLSE 947

  Fly   731 --VRTASSATLKRAPSANTVVEQRRGQQPNVPPQQAPPPPPPAPPSTLNEDDLNVTLDTLSLGND 793
              |||......::..|:|          .|.|..         ||| :|::..||. :|.:....
Mouse   948 GIVRTDEEEEEEQDASSN----------DNFPIY---------PPS-MNQNSYNVK-ETKTRWKS 991

  Fly   794 SIPSSSNRSQYMP--------PPMQPVPGM-WASHNS----GSSWHGQQPVYGQPSSSAGTEFKK 845
            :.|.|:: ..|.|        ..||....: |.|..|    ...|..|.           .:.||
Mouse   992 NRPVSAD-GNYRPLAKTRQQNISMQRQENLRWVSELSYIEEKEQWQEQI-----------NQLKK 1044

  Fly   846 LPAAQQGGSSNGSGSNASTDAVLLQQFMQTQQ---------------------------MLINSV 883
                |...|.|           :.|..||.||                           ::::.:
Mouse  1045 ----QLDFSVN-----------ICQTLMQDQQTLSCLLQTLLTGPYSVLPSNVASPQVHLIMHQL 1094

  Fly   884 CQCNQALWHQQREIDNLNHQLHALQDRFNVVACQDHSFGLRSE----SVPPPVGPGMGQMPNNLC 944
            .||...|..||..:..|...|..|..:.|     .|....||:    |...|      ..||..|
Mouse  1095 NQCYTQLTWQQNNVQRLKQMLTELMRQQN-----QHPEKPRSKERGSSASHP------SSPNLFC 1148

  Fly   945 LGSSRAQSEQLFNFGAHQSAFSNYQRSC----------HRSGAESHHHQQQQHQAQPFLNN---- 995
            ..|...|...|||.    ..|:|:....          ...|..|.:......|.||...|
Mouse  1149 PFSFPTQPVNLFNL----PGFTNFPSFAPGMNFSPLFPSNFGDFSQNVSTPTEQQQPLAQNPSGK 1209

  Fly   996 ----AAPPPPPTHFNNETPL-------------------SPPTYRSSPG---PIFMNHHNNTIHQ 1034
                |.|.|    |.:.:.|                   :|..|....|   |.|......::.:
Mouse  1210 TEYMAFPKP----FESSSSLGAEKQRNQKQPEEEAENTKTPWLYDQEGGVEKPFFKTGFTESVEK 1270

  Fly  1035 -NNSNLRTQ-----------NQHANNLHSLPEG---------------------AAGGGAPGGGI 1066
             .|||.:.|           .:...:..|:|:.                     |:....|....
Mouse  1271 ATNSNRKNQPDTSRRRRQFDEESLESFSSMPDPIDPTTVTKTFKTRKASAQASLASKDKTPKSKS 1335

  Fly  1067 TLNNQVPPGNRANNY--------------------WDNFRSHSRQ-------NLLSNKSNEELNV 1104
            ...|.....:|..|.                    ..|...||.|       .|.|.|::|:|..
Mouse  1336 KKRNSTQLKSRVKNIAVTFFTRGYESASVSSTCEPCKNRNRHSAQTEEPVQAKLFSRKNHEQLEK 1400

  Fly  1105 DLQQYR-------------------------------RQRARPSY----FQPPQLLPPTTRGGLT 1134
            .::..|                               :..:||.:    |...|||      ...
Mouse  1401 IIKYSRSAEISSETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLL------NTD 1459

  Fly  1135 HQQQRRHFFEAPLTALHGSSSNGSNNLN----NSGSSGRKRDW---------------RDDAGHI 1180
            :.:||..:....:.:.|.|.|:.....|    |||:      |               .||....
Mouse  1460 YLRQRALYALQDIVSRHISESDEREGENVKPVNSGT------WVASNSELTPSESLVTTDDETFE 1518

  Fly  1181 RDHDDEDVDEVEENH-DNVIFGS-------------GRRRNRRRPQLSTLRDDE---SEQASSSN 1228
            ::.:.|.....|:|. |||...|             |.........|:.:|:.|   :|..|.||
Mouse  1519 KNFERETHKVSEQNDADNVSVMSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTETESHSN 1583

  Fly  1229 LNMNVNYGNSPLYQRNKVPAKPTTSTVSLTPLQQRHLRFDFELPAHYMDYIELPQITPVDT---- 1289
            :......    :...:...|..|.|....||:.:.|   :...|...:..:..|:|   ||
Mouse  1584 MRCTCRV----IEDEDGAAAAATVSNSEETPIIENH---NSPQPISDVSAVPCPRI---DTQQLD 1638

  Fly  1290 --TPTLGQEASPADESNAMEQTEETASEEL----NRNLLVNALKND------KFTTKFYESIKED 1342
              ...:.:|..|.    ..|..:|..|.:|    .|.:|....:||      ||..|...||.:|
Mouse  1639 RQIKAIMKEVIPF----LKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQD 1699

  Fly  1343 -----VYRRL------------ETLFEQQQQQQQQQQQQN------QQLQHSHEPHGLRKA---- 1380
                 ..|:|            |.||.:....:..|...|      |:.:...|..|:|::
Mouse  1700 SLAKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSIAVKQRCKRKIEAAGVRQSYAKE 1764

  Fly  1381 ----LNQEENEPTG-------DAEATESRSET----------PLEVMRLQLDNDRPEDEKGTPV- 1423
                |..:...|.|       |.:.||:..:|          |..|.....|.:..|:.:..||
Mouse  1765 AKRILEGDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDAKGPKNVRSDVSDQEEDEESERCPVS 1829

  Fly  1424 ------KQLSLSNPQNG------QHLDEMEDSASAVISSLR--------TENEEQILEGKLEQAS 1468
                  :..:|:|..:|      :.:::.|:|...:.:||:        .|::.|||:..||:..
Mouse  1830 INLSKAESQALTNYGSGEDENEDEEMEDFEESPVDIQTSLQANTETTEENEHDSQILQHDLEKTP 1894

  Fly  1469 GSGSGPGTSIELAPDHELIEYIIKRIRNQTHNNTVINDSLLAEVSKLTATAAQNSTASSPLISPK 1533
            .|.:.|......:.:.:....:.....|...|...:|.:...:....|.::.|......||.:.:
Mouse  1895 ESTNVPSDQEPTSKNDQDSSPVKPCYLNILENEQQLNSATHKDSLTTTDSSKQPEPLPLPLAASE 1959

  Fly  1534 RIYAKIKKMDIPRQRDEFLLWYRSYLEQLFVVEQPQDSCKTKSKVTPSGASPAKLKNQRVRKQSQ 1598
            .:..::|:                       |:..|::.::....:|...||..:.:......:.
Mouse  1960 TLVPRVKE-----------------------VKSAQETPESSLAGSPDTESPVLVNDYEAESGNI 2001

  Fly  1599 SQSQDSNN-----DADL--------------AEADQKNVSSAGNGELECENNENPDEEADG--QA 1642
            ||..|..:     |..|              .|.:|||..|   ||: ||..   .||..|  |.
Mouse  2002 SQKSDEEDFVKVEDLPLKLTVYSEEELRKKMIEEEQKNHLS---GEI-CEMQ---TEELAGNSQI 2059

  Fly  1643 AAEPSGAEKQDV 1654
            ..||.....|.:
Mouse  2060 LKEPETVGAQSI 2071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmb	NP_729901.1	Smc	339..>720	CDD:224117	99/540 (18%)
Pcm1	XP_036009708.1	PCM1_C	1415..2045	CDD:406208	123/681 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CMS0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900