DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmb and pcm1

DIOPT Version :9

Sequence 1:	NP_729901.1	Gene:	cmb / 39513	FlyBaseID:	FBgn0036365	Length:	1657	Species:	Drosophila melanogaster
Sequence 2:	XP_012811113.2	Gene:	pcm1 / 100145303	XenbaseID:	XB-GENE-958591	Length:	2034	Species:	Xenopus tropicalis

Alignment Length:	2020	Identity:	386/2020 - (19%)
Similarity:	653/2020 - (32%)	Gaps:	630/2020 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KVVVDQANASARSNGSSNNNSVGGATGAVPKQQTPVNGAPTSGSSASVTSSRSARSRRQQEHLGE 70
            |..::.::...||.||   :|.|.||.|..|:|...|..|.:.....:.:::...|:
Frog   102 KQKINFSDLDQRSIGS---DSQGRATAANNKRQLADNRKPFNFLPLQLNTNKEKSSK-------- 155

  Fly    71 PDMELVEPETLQRETLKTLNDLLQRARITNAKNRSPAEQHLSSKDHRSPAQQQQQ---------- 125
                  .|...:..|:.:..|.|  |...|....|.::..|..:..|.||....|
Frog   156 ------SPPKRESSTISSTKDFL--ASAFNKDFLSNSQAFLEEESQREPAIDSSQVVSRLVQIRD 212

  Fly   126 ----REALRQLAAE----HGNYD----TAEQLQEQQQRYRFPVRPVQRVQHQPS-----SSANST 173
                ..:||....|    ..|.|    ..|.|:.|::.|...::.:...:::..     .||..:
Frog   213 YITKASSLRDDLVEKNDLSANIDRLSNLIEHLKFQEKSYLKFLQKMLASENEEDDVRTVDSAMGS 277

  Fly   174 GAPSSSTALLRLRQSTPPNA--TVGVVIPNATTSNGNGNLSGNEEQAPPLTPAGLQQLVHR---- 232
            |:.:.||:   |....|..|  |.||    .........|...::|...||....||...|
Frog   278 GSVAESTS---LNIDVPSEASDTTGV----DPQQEAKEELKNMKKQHALLTRMLQQQEQLRALKG 335

  Fly   233 ----LLGVHHFAPRTEGFRSQVDVLRALLGLDENLNSRYQPSRKVVETNNMVHEINPNSDQGEGV 293
                ||.:.|.|.:|            :..:||::         |.||...|..::..|:..|.:
Frog   336 RQAALLALQHKAEQT------------IAKMDESV---------VTETTGSVSGLSLASELNEEL 379

  Fly   294 VN-----STSLEDVALSEMSDNRAQSIQSL-----------HSVLETPTPDTTPSFD------EL 336
            .:     ...|.|.....:.|||.|: :||           .|..:||..|.:|.|:      |.
Frog   380 NDLIQRFHNQLHDSEDPPVPDNRRQA-ESLSLAREVYRSRNSSSSDTPLEDKSPLFNKVGVLLEK 443

  Fly   337 QQRLEASNRNMQHLHDEQAKLLQIQNLAKTHLNEMERL------RQQAD----------SLPHNV 385
            :|:::.....:..|||:             |||....:      |:..|          :|..:.
Frog   444 KQKMDTLLGELHTLHDQ-------------HLNNTAFMVSSVSPRRSTDQRTLGCAISAALSSDN 495

  Fly   386 NGGEAP----KYE--SVQQVQDD-----------MASLVGRMKNLTAFIHNQNELSTVLGD---- 429
            ....:|    .|:  ||.:.:|:           :..:..|:..|...:|...:.|.::.|
Frog   496 RAANSPITVGTYQAASVNESEDEENQNPAEKLKKLKEVRKRLNELRELVHYYEQTSDMVTDAMNE 560

  Fly   430 --------DGPEILAEQEALQEKLESLR--------------------TQREDMRNLVDELNSIN 466
                    :..|..:|||. .|...::|                    |...|.|.|..|....|
Frog   561 NTKDEDETEDSEYESEQED-DEPATNIRNPQYRSGWAQMNINSNAQSGTNNRDERQLNTECEINN 624

  Fly   467 RAARETARV-------------IKEKEETPTPPPKPEEAAPAAPKERVVPVEYQRNVPIIRQEAA 518
            |:|.....:             ..:|||.....|..|:|.....:   ..:..|.:|       |
Frog   625 RSAVNLRSINMSSALDCLYNIEHSDKEEDGNGEPDDEDAEDQGSR---ASLSSQNSV-------A 679

  Fly   519 NAAQRALHAQAMINQKTADIEALKAQMARLKGMLYTVSQIEESTPSMGSTLERRSEERTSVERE- 582
            :..|. :..:...|:..|..:.|| |:..|..|....|:.|...|....:.::...|.|:::::
Frog   680 DDVQN-VDFEQKFNRLVAAKQKLK-QLQDLVAMYGDDSESEPVAPERSFSGDQLPPETTTLKQQP 742

  Fly   583 ---LPAEIAQRVFALNDVTSE---------LRAEAASLQKERDRILALKAEIERRKQQAAAAVQM 635
               .|.....:..||.:...|         .:.|...||:||.:::.::.:|:..: :|...:|:
Frog   743 NNTRPNASKAKDIALKEQAREKFYESKLQQQQRELRQLQEERKKLIEIQEKIQTLR-KACPDLQL 806

  Fly   636 GDDAL--------KRSSLTPTPTP--------MRQRMTEEEDPSEVDNSLQATPTKEQ-LRDELR 683
            ...:.        .|...|.|.||        :...|.:.||.|.:||.:.:...|.| ||::||
Frog   807 STSSAGTNPRNRQNRQMTTTTSTPEVTTNSKNVVPAMPDPEDSSSIDNEVWSEIRKHQILREDLR 871

  Fly   684 SQCERLRTEYEQKQRELEQRYVASNNTTSEADDEANDDTDSDKYFANVRTASSATLKRAPSANTV 748
            .:.::|.|...:.||...|       |.:......:||:|:..:....|| ...|.....|....
Frog   872 QRRKQLETLMAEHQRRQGQ-------TDTSGASVRSDDSDTQGFQQQTRT-EKTTATWGGSTQCA 928

  Fly   749 VEQRRGQQPNVPPQQAPPPPPPAPPSTLNEDD-----------LNVTLDTLSLGNDSIPSSSNRS 802
            :::....                     ||||           ..:.::....||.|..:||...
Frog   929 LDEDDDD---------------------NEDDDDDDEGCLSDVHQIDIEDDEQGNTSCENSSYHQ 972

  Fly   803 QYMPPPMQPVPGMWASHNSGSSWHGQQP--VYGQPSSSAGTEFKKLPAAQQGGSSNGSGSNASTD 865
            ..:...      |....:|.:.|..|:|  |.|....|..|.       ||        .|.|
Frog   973 NSIRKT------MLNGRSSKNGWKNQRPFSVEGNHRPSPKTR-------QQ--------QNVS-- 1014

  Fly   866 AVLLQQFMQTQQMLINSVCQCNQALW-----------HQQREIDNLNHQLHALQDRFNVVACQ-- 917
                   |:.|:          ...|           |.|.:||.:..||.     ::...||
Frog  1015 -------MRRQE----------NYRWMSELSHVEEKEHWQGQIDQIKKQLD-----YSTNICQTL 1057

  Fly   918 --DH---SFGLRSESVPPPVGPGMGQMPNNLCLGSSRAQ------SEQLFNFGAHQSAFSNYQRS 971
              |.   |:.|:|....|     ...:|:|  :|:.:.|      ::........||.....::.
Frog  1058 MRDQQTLSYLLQSMITSP-----YSVLPSN--VGAPQVQLIMHQLNQCYTQLNWQQSNVLRLKQM 1115

  Fly   972 CHRSGAESHHHQQQQHQAQPFLNNAAPPP--PPTHFNNETPLSPPTYRSSPGPIFMNHHNNTIHQ 1034
            .:...|:...|.|.:.|.:....::||||  .|..|.|...| |||.
Frog  1116 LNDLLAQQQQHLQGESQQREDRGSSAPPPLTSPNIFTNFGFL-PPTM------------------ 1161

  Fly  1035 NNSNLRTQNQHANNLHSLPEGAAGGGAPGGGITLNNQVPPGNRANNYWDNFRSHSRQNLLSNKSN 1099
                         ||.::|.|:.....|  |:..|...|.|  ..|:..|..||:...|..:..|
Frog  1162 -------------NLLNMPFGSIPSVVP--GVNFNPGFPHG--FENFAQNVTSHADTPLQPHDQN 1209

  Fly  1100 EELNVDLQQYRRQRARPSYFQPPQLLPPTTRGGLTHQQQRRHFFEAPLTALHGSSSNGSNNLNN- 1163
            .....:...:      |..|:             :|                  :||.:....|
Frog  1210 TSGKTEYMAF------PKPFE-------------SH------------------TSNSTEKERNE 1237

  Fly  1164 -----SGSSGRKRDWRDDAGHIRDHDDEDVDE--------VEENHDNVIFGSGRRRNRRRPQLST 1215
                 .|..|| |.|      :.:|...|.::        :.|       |||............
Frog  1238 PKKPDEGEQGR-RIW------VENHQKNDQEKKAGCFGAGISE-------GSGTSAKLAEESWKG 1288

  Fly  1216 LRDDESEQASSSNLNMNVNYGN-SPLYQRNKVPAKPTTSTVSLTPLQQRHLRFDFELPAHYMDYI 1279
            .:.||....|.|::...|:... :.:::..|..|:.:.::...||..:...|..|...:..:..|
Frog  1289 KQFDEVSVESLSSMPDPVDPTTVTKMFKSRKASAQASLASKDKTPKAKNKKRKIFHQKSKGIKSI 1353

  Fly  1280 -------ELPQITPVDTTPTLGQEASPADESNAMEQTE-ETASEELNRNLLVNALKNDKFTTKFY 1336
                   ..|..|......|.|........:::.::|| |:.:.||:     :...:|   ...:
Frog  1354 GASGFNVSEPNQTGCRHAQTEGATVGKVTTTSSAQRTEKESKATELS-----SEAGSD---VSMF 1410

  Fly  1337 ESIKEDVYRRLETLFEQQQQQQQQQQQQNQQLQHSHEPHGLRKALNQEENEPTGDAEATES---R 1398
            |::::.:|..:.||..|.:.:.....:...:||..:..|..:|||...::..|  ...|||   :
Frog  1411 ETLRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDHLRQKALFALQDIVT--RRITESNVKK 1473

  Fly  1399 SET---PLEVMRLQLDNDR--PEDEKGTPVKQLSLSNPQNGQHLDEMEDSASAVISSLRT----- 1453
            .||   |||.......|..  |.:...|...:|...| .:|....|:|.:.:..||||.|
Frog  1474 HETCTKPLESAGWMASNSELTPSESLVTTDDELYAKN-SDGPACQEIEQNDADNISSLSTSSNFE 1537

  Fly  1454 -----------------------------ENEEQI--------------LEGKLEQASGSGSGPG 1475
                                         |.|:.:              |||..:::.|......
Frog  1538 PFATDDLGNTVIHFDQALARMREYERMKNETEDSLVADCCNHLNAAASSLEGTNDESRGHAQHSA 1602

  Fly  1476 TSIELAP----DHELIEYIIKRIRNQT------HNNTVINDSLLAEVSKLTATAAQNSTASSPLI 1530
            ......|    |.:.::..||.|..:.      |...|.:.:||..:.:|..|..|.:..|...:
Frog  1603 DDASAIPCPYIDSKQLDRQIKAIMKEVIPFLKEHMEEVCSPNLLTSIRRLVLTLTQQNDESKEFV 1667

  Fly  1531 SPKRIYAK---------IKKMDIPRQRD--EFLLWYRSYLEQLF--------------------- 1563
               :.:.|         :.|....:.:|  |.||...|  |.||
Frog  1668 ---KFFHKQLGSILQDSLAKFSNKKLKDCGEDLLVEIS--EVLFNELAFFRLMQDLDNNSAAVQG 1727

  Fly  1564 VVEQPQDSCKTKSKVTPSGASPAKL------------KNQRVRKQSQSQSQDSNN-DA------- 1608
            .|.:..|:.......|..|....||            .::...|.....:|:|.| ||
Frog  1728 KVSKKPDAAVVLESFTKEGDKEEKLCQDENFSATREIDDEDKDKDDTEAAQESRNIDAEVLSGKS 1792

  Fly  1609 DLAEADQKN----------------VSSAGNGELECENNENPDEEA---DGQAAAEPSG-----A 1649
            |::|.|..|                :::.|:||.|.|..||.:.||   |.|.:.|.|.     .
Frog  1793 DISEEDDVNENLPVSISLSKAETQALTNYGSGEDENEEEENYEFEARPVDVQTSLETSSEIADET 1857

  Fly  1650 EKQDV 1654
            ||:::
Frog  1858 EKEEM 1862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmb	NP_729901.1	Smc	339..>720	CDD:224117	90/488 (18%)
pcm1	XP_012811113.2	PCM1_C	1404..2001	CDD:406208	94/470 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007074
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000