DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flr and WDR1

DIOPT Version :9

Sequence 1:	NP_648642.1	Gene:	flr / 39505	FlyBaseID:	FBgn0260049	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	XP_016864369.1	Gene:	WDR1 / 9948	HGNCID:	12754	Length:	659	Species:	Homo sapiens

Alignment Length:	658	Identity:	292/658 - (44%)
Similarity:	414/658 - (62%)	Gaps:	64/658 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENKNIYATLPRTQRGQPIVLGADPKGKNFLYTNGNSVIIRNIENPAIADVYTEHSCAVNVAKYS 73
            ||.|.::|:||:.:||...::|.||||.|||||||..||:|||:|||:||:||||:..|.||||:
Human     3 YEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYA 67

  Fly    74 PSGFYIASGDASGKIRIWDTVNKEHLLKNEFQPIAGPIKDISWSPDNQRIVAVGEGRERFGHVFM 138
            ||||||||||.|||:|||||..||||||.|:||.||.||||:|:.|::||..||||||:||.||:
Human    68 PSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFL 132

  Fly   139 SETGTSVGEISGQSKSINSADFRPARPFRIVTGSEDNTIAVFEGPPFKFKMTKQDHSRFVQAVRY 203
            .::|:|||||:|.:|.|||.|.:.:||:|:.|||:||..|.|||||||||.|..||||||..||:
Human   133 WDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRF 197

  Fly   204 SPDGKFFASAGFDG--------------------------------------------------- 217
            ||||..||:|..||
Human   198 SPDGNRFATASADGQTRRQSPVNACLLLNHTGSLVCEPRFSTATVHGETAYSRGCSHTHDPHVFI 262

  Fly   218 --KVFLYDGTSSELVGEF-GSPAHKGGVYALAWKPDSTQLLTCSGDKTCRLWTVESRELVSEFVM 279
              |:::|||.:.|.|... ||.||.||:||::|.||||.||:.|||||.::|.|....:||.|.|
Human   263 SWKIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPM 327

  Fly   280 GTTVDDQQVSCLWQGDNLITVSLSGVITYLNVADPSKPLRVVKGHNKPITVLGL--SDDRSTIYT 342
            |:||.|||:.||||.|:|::|||||.|.||:..:|||||.|:|||:|.|..|.:  :..:|.||:
Human   328 GSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYS 392

  Fly   343 GSHDGVVTNWNSGSGTNDRITGTGHGNQINGIAA--WGDFVYTCGIDDSLRQFSVEGNSYTDY-V 404
            |||||.:..|:|.:|.||...|.||.||::.:..  .|..: :|.:||::|..|:....|:.. |
Human   393 GSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLI-SCSMDDTVRYTSLMLRDYSGQGV 456

  Fly   405 VKLNCQPRGLAILRNENIIALACIKELTLVQDQKKIFSLPIK-YEASSIAVNADTSDVAVGGDDQ 468
            |||:.||:.:|: .......:.||.::.|::||:|.||:... ||...:||:.....||:||.|.
Human   457 VKLDVQPKCVAV-GPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDG 520

  Fly   469 KLHIYTLKGGVLEPKVE-LDHLGAVTDVSYSPDLKYLVACDAHRKVVLYSVEEYKPAHNKEWGFH 532
            .:.:|::.|..|:.:.: |:..|.||||:||.|..:|..|||.:.|.::||.:....:|..:| |
Human   521 NVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYG-H 584

  Fly   533 SARVNTVAWSPNSLLVASGSLDTTIIIWSVANPAKHTIIKNAHPQSQITRLVWLDNNTVISTGQD 597
            .|::..:||||::...|||.:|..:.:|::::|.....|::||....::.|.|||.:|:::|..|
Human   585 HAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHD 649

  Fly   598 CNTKVWHV 605
            .:.|.|.:
Human   650 ASVKEWTI 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flr	NP_648642.1	WD40	26..557	CDD:225201	270/591 (46%)
		WD40	59..353	CDD:238121	176/349 (50%)
		WD40 repeat	68..106	CDD:293791	29/37 (78%)
		WD40 repeat	111..149	CDD:293791	23/37 (62%)
		WD40 repeat	156..192	CDD:293791	22/35 (63%)
		WD40 repeat	198..234	CDD:293791	18/89 (20%)
		WD40 repeat	242..278	CDD:293791	18/35 (51%)
		WD40 repeat	287..306	CDD:293791	12/18 (67%)
		WD40	317..607	CDD:295369	103/296 (35%)
		WD40 repeat	330..352	CDD:293791	9/23 (39%)
		WD40 repeat	372..407	CDD:293791	9/37 (24%)
		WD40 repeat	411..442	CDD:293791	8/30 (27%)
		WD40 repeat	450..485	CDD:293791	10/34 (29%)
		WD40 repeat	492..528	CDD:293791	15/35 (43%)
		WD40	520..>607	CDD:225201	26/86 (30%)
		WD40 repeat	536..573	CDD:293791	11/36 (31%)
		WD40 repeat	580..603	CDD:293791	8/22 (36%)
WDR1	XP_016864369.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157066
Domainoid	1	1.000	135	1.000	Domainoid score	I5003
eggNOG	1	0.900	-	-		E1_KOG0318
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6628
Inparanoid	1	1.050	578	1.000	Inparanoid score	I1031
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53916
OrthoDB	1	1.010	-	-		D179485at33208
OrthoFinder	1	1.000	-	-		FOG0003250
OrthoInspector	1	1.000	-	-		oto88737
orthoMCL	1	0.900	-	-		OOG6_102813
Panther	1	1.100	-	-	LDO	PTHR19856
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1789
SonicParanoid	1	1.000	-	-		X2198
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800