Protein Alignment flr and wdr1

DIOPT Version :10

• Sequence 1: NP_648642.1
• Gene: flr / 39505
• FlyBaseID: FBgn0260049
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_001006781.1
• Gene: wdr1 / 448473
• XenbaseID: XB-GENE-489897
• Length: 607
• Species: Xenopus tropicalis
• Alignment Length: 608
• Identity: 301/608 - (49%)
• Similarity: 416/608 - (68%)
• Gaps: 17/608 - (2%)

  Fly     9 YENKNIYATLPRTQRGQPIVLGADPKGKNFLYTNGNSVIIRNIENPAIADVYTEHSCAVNVAKYS 73
            ||.|.::|:||:.:||...::..||||.|||||||.||||||||||||||:||||:..|.||:|:
 Frog     3 YELKKVFASLPQVERGVAKIITGDPKGNNFLYTNGKSVIIRNIENPAIADIYTEHAHPVVVARYA 67

  Fly    74 PSGFYIASGDASGKIRIWDTVNKEHLLKNEFQPIAGPIKDISWSPDNQRIVAVGEGRERFGHVFM 138
            ||||||||||.|||:|||||..||||||.|:||.||.||||:|:.|::||..||||||:||.||:
 Frog    68 PSGFYIASGDTSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGSVFL 132

  Fly   139 SETGTSVGEISGQSKSINSADFRPARPFRIVTGSEDNTIAVFEGPPFKFKMTKQDHSRFVQAVRY 203
            .:||:|||||||..|.|||.|.:..||:|:||||:||..|.|||||||||.|..||||||..||:
 Frog   133 WDTGSSVGEISGNIKVINSVDIKQTRPYRLVTGSDDNCCAFFEGPPFKFKFTMADHSRFVNCVRF 197

  Fly   204 SPDGKFFASAGFDGKVFLYDGTSSELVGEF-GSPAHKGGVYALAWKPDSTQLLTCSGDKTCRLWT 267
            ||||...||||.||::|||||.:.|.||.. ||.||.||:||::|..||||||:.|||||.::|.
 Frog   198 SPDGSRLASAGADGQIFLYDGKTGEKVGNLGGSKAHDGGIYAVSWSADSTQLLSASGDKTAKIWD 262

  Fly   268 VESRELVSEFVMGTTVDDQQVSCLWQGDNLITVSLSGVITYLNVADPSKPLRVVKGHNKPITVLG 332
            |.:...|:.|.:||.|.|||:.||||.|.|::|||||.|.||:..:||:||||:|||||.|..:.
 Frog   263 VAANSAVTTFHLGTEVLDQQLGCLWQKDYLLSVSLSGYINYLDKNNPSRPLRVIKGHNKSIQCMT 327

  Fly   333 L--SDDRSTIYTGSHDGVVTNWNSGSGTNDRITGTGHGNQINGIAAWGDF-----VYTCGIDDSL 390
            :  ||.|||||||||||.:..|::.:|.||..||.||.||::.:    |.     :.||.:||::
 Frog   328 VHNSDGRSTIYTGSHDGHINYWDAETGENDTFTGKGHTNQVSRM----DLDSSNQLITCSMDDTV 388

  Fly   391 RQFSVEGNSY-TDYVVKLNCQPRGLAILRNENIIALACIKELTLVQDQKKIFSL-PIKYEASSIA 453
            |..|:....| :...||::.||:.:|:.....::.| ||.::.|::|:||:|:: .:.||..::|
 Frog   389 RYTSLTSKDYSSSESVKMDVQPKCVAVGSGGYVVTL-CIGQIVLLKDKKKVFAIDSLDYEPEAVA 452

  Fly   454 VNADTSDVAVGGDDQKLHIYTLKGGVLEPK-VELDHLGAVTDVSYSPDLKYLVACDAHRKVVLYS 517
            ::..:..|||||.|..:|:|:::|..|:.: ..|...|||||::||.|..:|...||::.|.:::
 Frog   453 IHKGSGTVAVGGVDGNVHLYSIQGNSLKDEGKSLPVKGAVTDLAYSHDGAFLAVTDANKVVTVFN 517

  Fly   518 VEEYKPAHNKEWGFHSARVNTVAWSPNSLLVASGSLDTTIIIWSVANPAKHTIIKNAHPQSQITR 582
            |.:.....|..:| |.|:..:|||||::...||..:|..:.:|::::|.....|.:||....::.
 Frog   518 VADGYSEQNVYYG-HHAKAVSVAWSPDNEHFASSGMDMMVYVWTLSDPDARIKIPDAHRLHHVSS 581

  Fly   583 LVWLDNNTVISTGQDCNTKVWHV 605
            |.|||.:|:.:...|...|.|.|
 Frog   582 LAWLDEHTLATVSHDACVKQWTV 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
flr	NP_648642.1	WD40	16..397	CDD:441893	231/388 (60%)
		WD40 repeat	68..106	CDD:293791	28/37 (76%)
		WD40 repeat	111..149	CDD:293791	24/37 (65%)
		WD40 repeat	156..192	CDD:293791	23/35 (66%)
		WD40 repeat	198..234	CDD:293791	21/36 (58%)
		WD40 repeat	242..278	CDD:293791	17/35 (49%)
		WD40 repeat	287..306	CDD:293791	12/18 (67%)
		WD40 repeat	330..352	CDD:293791	13/23 (57%)
		WD40 repeat	372..407	CDD:293791	9/40 (23%)
		WD40 repeat	411..442	CDD:293791	9/30 (30%)
		WD40 repeat	450..485	CDD:293791	11/35 (31%)
		WD40	488..>607	CDD:475233	39/118 (33%)
		WD40 repeat	492..528	CDD:293791	12/35 (34%)
		WD40 repeat	536..573	CDD:293791	11/36 (31%)
		WD40 repeat	580..603	CDD:293791	7/22 (32%)
wdr1	NP_001006781.1	WD 1. /evidence=ECO:0000255	4..45		23/40 (58%)
		WD 2. /evidence=ECO:0000255	48..87		29/38 (76%)
		WD40	54..389	CDD:238121	199/338 (59%)
		WD40 repeat	62..100	CDD:293791	28/37 (76%)
		WD 3. /evidence=ECO:0000255	93..135		26/41 (63%)
		WD40 repeat	105..143	CDD:293791	24/37 (65%)
		WD 4. /evidence=ECO:0000255	138..176		23/37 (62%)
		WD40 repeat	150..186	CDD:293791	23/35 (66%)
		WD 5. /evidence=ECO:0000255	180..218		25/37 (68%)
		WD40	184..605	CDD:441893	180/427 (42%)
		WD40 repeat	192..228	CDD:293791	21/35 (60%)
		WD 6. /evidence=ECO:0000255	224..263		23/38 (61%)
		WD40 repeat	237..275	CDD:293791	18/37 (49%)
		WD 7. /evidence=ECO:0000255	270..306		21/35 (60%)
		WD 8. /evidence=ECO:0000255	311..351		24/39 (62%)
		WD40 repeat	325..362	CDD:293791	18/36 (50%)
		WD 9. /evidence=ECO:0000255	358..408		16/53 (30%)
		WD40 repeat	368..389	CDD:293791	5/24 (21%)
		WD40 repeat	421..483	CDD:293791	21/62 (34%)
		WD 10. /evidence=ECO:0000255	432..474		15/41 (37%)
		WD 11. /evidence=ECO:0000255	480..518		13/37 (35%)
		WD40 repeat	492..528	CDD:293791	12/35 (34%)
		WD 12. /evidence=ECO:0000255	523..561		13/38 (34%)
		WD40 repeat	536..572	CDD:293791	11/35 (31%)
		WD 13. /evidence=ECO:0000255	566..604		11/37 (30%)
		WD40 repeat	579..602	CDD:293791	7/22 (32%)