DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flr and wdr1

DIOPT Version :9

Sequence 1:	NP_648642.1	Gene:	flr / 39505	FlyBaseID:	FBgn0260049	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_001006781.1	Gene:	wdr1 / 448473	XenbaseID:	XB-GENE-489897	Length:	607	Species:	Xenopus tropicalis

Alignment Length:	608	Identity:	301/608 - (49%)
Similarity:	416/608 - (68%)	Gaps:	17/608 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENKNIYATLPRTQRGQPIVLGADPKGKNFLYTNGNSVIIRNIENPAIADVYTEHSCAVNVAKYS 73
            ||.|.::|:||:.:||...::..||||.|||||||.||||||||||||||:||||:..|.||:|:
Frog     3 YELKKVFASLPQVERGVAKIITGDPKGNNFLYTNGKSVIIRNIENPAIADIYTEHAHPVVVARYA 67

  Fly    74 PSGFYIASGDASGKIRIWDTVNKEHLLKNEFQPIAGPIKDISWSPDNQRIVAVGEGRERFGHVFM 138
            ||||||||||.|||:|||||..||||||.|:||.||.||||:|:.|::||..||||||:||.||:
Frog    68 PSGFYIASGDTSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGSVFL 132

  Fly   139 SETGTSVGEISGQSKSINSADFRPARPFRIVTGSEDNTIAVFEGPPFKFKMTKQDHSRFVQAVRY 203
            .:||:|||||||..|.|||.|.:..||:|:||||:||..|.|||||||||.|..||||||..||:
Frog   133 WDTGSSVGEISGNIKVINSVDIKQTRPYRLVTGSDDNCCAFFEGPPFKFKFTMADHSRFVNCVRF 197

  Fly   204 SPDGKFFASAGFDGKVFLYDGTSSELVGEF-GSPAHKGGVYALAWKPDSTQLLTCSGDKTCRLWT 267
            ||||...||||.||::|||||.:.|.||.. ||.||.||:||::|..||||||:.|||||.::|.
Frog   198 SPDGSRLASAGADGQIFLYDGKTGEKVGNLGGSKAHDGGIYAVSWSADSTQLLSASGDKTAKIWD 262

  Fly   268 VESRELVSEFVMGTTVDDQQVSCLWQGDNLITVSLSGVITYLNVADPSKPLRVVKGHNKPITVLG 332
            |.:...|:.|.:||.|.|||:.||||.|.|::|||||.|.||:..:||:||||:|||||.|..:.
Frog   263 VAANSAVTTFHLGTEVLDQQLGCLWQKDYLLSVSLSGYINYLDKNNPSRPLRVIKGHNKSIQCMT 327

  Fly   333 L--SDDRSTIYTGSHDGVVTNWNSGSGTNDRITGTGHGNQINGIAAWGDF-----VYTCGIDDSL 390
            :  ||.|||||||||||.:..|::.:|.||..||.||.||::.:    |.     :.||.:||::
Frog   328 VHNSDGRSTIYTGSHDGHINYWDAETGENDTFTGKGHTNQVSRM----DLDSSNQLITCSMDDTV 388

  Fly   391 RQFSVEGNSY-TDYVVKLNCQPRGLAILRNENIIALACIKELTLVQDQKKIFSL-PIKYEASSIA 453
            |..|:....| :...||::.||:.:|:.....::.| ||.::.|::|:||:|:: .:.||..::|
Frog   389 RYTSLTSKDYSSSESVKMDVQPKCVAVGSGGYVVTL-CIGQIVLLKDKKKVFAIDSLDYEPEAVA 452

  Fly   454 VNADTSDVAVGGDDQKLHIYTLKGGVLEPK-VELDHLGAVTDVSYSPDLKYLVACDAHRKVVLYS 517
            ::..:..|||||.|..:|:|:::|..|:.: ..|...|||||::||.|..:|...||::.|.:::
Frog   453 IHKGSGTVAVGGVDGNVHLYSIQGNSLKDEGKSLPVKGAVTDLAYSHDGAFLAVTDANKVVTVFN 517

  Fly   518 VEEYKPAHNKEWGFHSARVNTVAWSPNSLLVASGSLDTTIIIWSVANPAKHTIIKNAHPQSQITR 582
            |.:.....|..:| |.|:..:|||||::...||..:|..:.:|::::|.....|.:||....::.
Frog   518 VADGYSEQNVYYG-HHAKAVSVAWSPDNEHFASSGMDMMVYVWTLSDPDARIKIPDAHRLHHVSS 581

  Fly   583 LVWLDNNTVISTGQDCNTKVWHV 605
            |.|||.:|:.:...|...|.|.|
Frog   582 LAWLDEHTLATVSHDACVKQWTV 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flr	NP_648642.1	WD40	26..557	CDD:225201	279/541 (52%)
		WD40	59..353	CDD:238121	184/296 (62%)
		WD40 repeat	68..106	CDD:293791	28/37 (76%)
		WD40 repeat	111..149	CDD:293791	24/37 (65%)
		WD40 repeat	156..192	CDD:293791	23/35 (66%)
		WD40 repeat	198..234	CDD:293791	21/36 (58%)
		WD40 repeat	242..278	CDD:293791	17/35 (49%)
		WD40 repeat	287..306	CDD:293791	12/18 (67%)
		WD40	317..607	CDD:295369	107/299 (36%)
		WD40 repeat	330..352	CDD:293791	13/23 (57%)
		WD40 repeat	372..407	CDD:293791	9/40 (23%)
		WD40 repeat	411..442	CDD:293791	9/30 (30%)
		WD40 repeat	450..485	CDD:293791	11/35 (31%)
		WD40 repeat	492..528	CDD:293791	12/35 (34%)
		WD40	520..>607	CDD:225201	26/86 (30%)
		WD40 repeat	536..573	CDD:293791	11/36 (31%)
		WD40 repeat	580..603	CDD:293791	7/22 (32%)
wdr1	NP_001006781.1	WD 1. /evidence=ECO:0000255	4..45		23/40 (58%)
		WD 2. /evidence=ECO:0000255	48..87		29/38 (76%)
		WD40	54..389	CDD:238121	199/338 (59%)
		WD40 repeat	62..100	CDD:293791	28/37 (76%)
		WD 3. /evidence=ECO:0000255	93..135		26/41 (63%)
		WD40 repeat	105..143	CDD:293791	24/37 (65%)
		WD 4. /evidence=ECO:0000255	138..176		23/37 (62%)
		WD40 repeat	150..186	CDD:293791	23/35 (66%)
		WD 5. /evidence=ECO:0000255	180..218		25/37 (68%)
		WD40 repeat	192..228	CDD:293791	21/35 (60%)
		WD 6. /evidence=ECO:0000255	224..263		23/38 (61%)
		WD40	231..602	CDD:225201	149/376 (40%)
		WD40 repeat	237..275	CDD:293791	18/37 (49%)
		WD 7. /evidence=ECO:0000255	270..306		21/35 (60%)
		WD 8. /evidence=ECO:0000255	311..351		24/39 (62%)
		WD40 repeat	325..362	CDD:293791	18/36 (50%)
		WD 9. /evidence=ECO:0000255	358..408		16/53 (30%)
		WD40 repeat	368..389	CDD:293791	5/24 (21%)
		WD40 repeat	421..483	CDD:293791	21/62 (34%)
		WD 10. /evidence=ECO:0000255	432..474		15/41 (37%)
		WD 11. /evidence=ECO:0000255	480..518		13/37 (35%)
		WD40 repeat	492..528	CDD:293791	12/35 (34%)
		WD 12. /evidence=ECO:0000255	523..561		13/38 (34%)
		WD40 repeat	536..572	CDD:293791	11/35 (31%)
		WD 13. /evidence=ECO:0000255	566..604		11/37 (30%)
		WD40 repeat	579..602	CDD:293791	7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4805
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6628
Inparanoid	1	1.050	596	1.000	Inparanoid score	I956
OMA	1	1.010	-	-		QHG53916
OrthoDB	1	1.010	-	-		D179485at33208
OrthoFinder	1	1.000	-	-		FOG0003250
OrthoInspector	1	1.000	-	-		otm47723
Panther	1	1.100	-	-	LDO	PTHR19856
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1789
SonicParanoid	1	1.000	-	-		X2198
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110