DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flr and wdr1

DIOPT Version :9

Sequence 1:	NP_648642.1	Gene:	flr / 39505	FlyBaseID:	FBgn0260049	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_957333.1	Gene:	wdr1 / 394014	ZFINID:	ZDB-GENE-040426-804	Length:	606	Species:	Danio rerio

Alignment Length:	611	Identity:	287/611 - (46%)
Similarity:	404/611 - (66%)	Gaps:	25/611 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AYENKNIYATLPRTQRGQPIVLGADPKGKNFLYTNGNSVIIRNIENPAIADVYTEHSCAVNVAKY 72
            :||.|.::|:||..:||...|||.||||.|||||||.|||||||||||||||||||...|.||||
Zfish     2 SYELKRVFASLPHMERGVAKVLGGDPKGNNFLYTNGKSVIIRNIENPAIADVYTEHPHQVIVAKY 66

  Fly    73 SPSGFYIASGDASGKIRIWDTVNKEHLLKNEFQPIAGPIKDISWSPDNQRIVAVGEGRERFGHVF 137
            .||||||||||.|||:|||||..:|||||.|:||..|.||||:|:.|::|:..||||||:||.||
Zfish    67 CPSGFYIASGDVSGKVRIWDTTQREHLLKYEYQPFGGKIKDIAWTEDSKRLAVVGEGREKFGAVF 131

  Fly   138 MSETGTSVGEISGQSKSINSADFRPARPFRIVTGSEDNTIAVFEGPPFKFKMTKQDHSRFVQAVR 202
            :.:||:|||||.|.||.|||.|.:..||:|:||||:||.....||||||||.|..||||||..||
Zfish   132 LWDTGSSVGEIVGHSKIINSVDIKQTRPYRLVTGSDDNCTTFLEGPPFKFKCTMTDHSRFVNCVR 196

  Fly   203 YSPDGKFFASAGFDGKVFLYDGTSSELVGEF-GSPAHKGGVYALAWKPDSTQLLTCSGDKTCRLW 266
            :||||..:||||.||::|||||.:.|.:... |..||.||:||::|.||||||::.|||:|.:||
Zfish   197 FSPDGSRYASAGADGQIFLYDGKTGEKLSSLGGEKAHDGGIYAVSWSPDSTQLISASGDRTVKLW 261

  Fly   267 TVESRELVSEFVMGTTVDDQQVSCLWQGDNLITVSLSGVITYLNVADPSKPLRVVKGHNKPITVL 331
            .|.|...||.|.:|:.|.|||:.|||...:|::|||||.|.||:..:|::|||.:|||.|.|..:
Zfish   262 DVGSGTSVSTFSLGSDVLDQQLGCLWVNKHLLSVSLSGYINYLDRNNPNRPLRTIKGHTKSIQCV 326

  Fly   332 GL--SDDRSTIYTGSHDGVVTNWNSGSGTNDRITGTGHGNQINGIAA-WGDFVYTCGIDDSLRQF 393
            .:  :|.|::||:|||||.:..|::.||.|:...|.||.|.::.:.. ..:.:.||.:||::|..
Zfish   327 TVHKADGRTSIYSGSHDGHINYWDAESGENEAFVGKGHSNLVSRMMVDDAERLVTCSMDDTVRYT 391

  Fly   394 SVEGNSYT-DYVVKLNCQPR-------GLAILRNENIIALACIKELTLVQDQKKIFSL-PIKYEA 449
            .::...|: ..:||::.||:       |||:        ..||.:|.|::|:||:|:| .:.||.
Zfish   392 DLKKKEYSASDMVKMDVQPKCVSVGPGGLAV--------TVCIGQLVLLKDKKKLFTLDSLDYEP 448

  Fly   450 SSIAVNADTSDVAVGGDDQKLHIYTLKGGVLEPKVE-LDHLGAVTDVSYSPDLKYLVACDAHRKV 513
            .::||:.....|||||.|.|:|:|:::|..|:...: |:..|.|||:|||.|..:|...|..:.|
Zfish   449 EAVAVHPGGGTVAVGGADGKVHLYSVQGNTLKDDGKALEVQGPVTDMSYSKDGAFLAVTDEKKVV 513

  Fly   514 VLYSV-EEYKPAHNKEWGFHSARVNTVAWSPNSLLVASGSLDTTIIIWSVANPAKHTIIKNAHPQ 577
            .:::| :.||  ...|:..|.|:|..::|||::...|:..:|..:.:|:.::..|...:.:.|..
Zfish   514 TVFTVADAYK--EKSEFYGHHAKVVCLSWSPDNEHFATSGMDMMVYVWTASDTEKRIKLPDCHRL 576

  Fly   578 SQITRLVWLDNNTVISTGQDCNTKVW 603
            ..::.|.||:.||:::|..|...|.|
Zfish   577 HHVSGLAWLNPNTLVTTSHDACIKQW 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flr	NP_648642.1	WD40	26..557	CDD:225201	267/545 (49%)
		WD40	59..353	CDD:238121	170/296 (57%)
		WD40 repeat	68..106	CDD:293791	28/37 (76%)
		WD40 repeat	111..149	CDD:293791	23/37 (62%)
		WD40 repeat	156..192	CDD:293791	21/35 (60%)
		WD40 repeat	198..234	CDD:293791	19/36 (53%)
		WD40 repeat	242..278	CDD:293791	19/35 (54%)
		WD40 repeat	287..306	CDD:293791	10/18 (56%)
		WD40	317..607	CDD:295369	98/301 (33%)
		WD40 repeat	330..352	CDD:293791	9/23 (39%)
		WD40 repeat	372..407	CDD:293791	7/36 (19%)
		WD40 repeat	411..442	CDD:293791	11/37 (30%)
		WD40 repeat	450..485	CDD:293791	13/34 (38%)
		WD40 repeat	492..528	CDD:293791	13/36 (36%)
		WD40	520..>607	CDD:225201	23/84 (27%)
		WD40 repeat	536..573	CDD:293791	8/36 (22%)
		WD40 repeat	580..603	CDD:293791	8/22 (36%)
wdr1	NP_957333.1	WD40	53..389	CDD:238121	182/335 (54%)
		WD40	54..426	CDD:225201	190/379 (50%)
		WD40 repeat	62..100	CDD:293791	28/37 (76%)
		WD40 repeat	105..143	CDD:293791	23/37 (62%)
		WD40 repeat	150..186	CDD:293791	21/35 (60%)
		WD40 repeat	192..228	CDD:293791	19/35 (54%)
		WD40 repeat	237..263	CDD:293791	15/25 (60%)
		WD40 repeat	278..317	CDD:293791	20/38 (53%)
		WD40	312..602	CDD:295369	97/299 (32%)
		WD40 repeat	325..361	CDD:293791	13/35 (37%)
		WD40 repeat	424..485	CDD:293791	24/60 (40%)
		WD40 repeat	492..530	CDD:293791	14/39 (36%)
		WD40 repeat	535..559	CDD:293791	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6628
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D179485at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010