DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flr and Wdr1

DIOPT Version :9

Sequence 1:	NP_648642.1	Gene:	flr / 39505	FlyBaseID:	FBgn0260049	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_035845.1	Gene:	Wdr1 / 22388	MGIID:	1337100	Length:	606	Species:	Mus musculus

Alignment Length:	610	Identity:	297/610 - (48%)
Similarity:	413/610 - (67%)	Gaps:	21/610 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENKNIYATLPRTQRGQPIVLGADPKGKNFLYTNGNSVIIRNIENPAIADVYTEHSCAVNVAKYS 73
            ||.|.::|:||:.:||...:||.||||.:||||||..||:|||:||||||:||||:..|.||||:
Mouse     3 YEIKKVFASLPQVERGVSKILGGDPKGDHFLYTNGKCVILRNIDNPAIADIYTEHAHQVVVAKYA 67

  Fly    74 PSGFYIASGDASGKIRIWDTVNKEHLLKNEFQPIAGPIKDISWSPDNQRIVAVGEGRERFGHVFM 138
            ||||||||||.|||:|||||..||||||.|:||.||.||||:|:.|::||..||||||:||.||:
Mouse    68 PSGFYIASGDISGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFL 132

  Fly   139 SETGTSVGEISGQSKSINSADFRPARPFRIVTGSEDNTIAVFEGPPFKFKMTKQDHSRFVQAVRY 203
            .:||:|||||:|.:|.|||.|.:..||:|:.|||:||..|.|||||||||.|..||||||..||:
Mouse   133 WDTGSSVGEITGHNKVINSVDIKQTRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRF 197

  Fly   204 SPDGKFFASAGFDGKVFLYDGTSSELVGEFG-SPAHKGGVYALAWKPDSTQLLTCSGDKTCRLWT 267
            ||||..||:|..||::|:|||.:.|.|...| |.||.||:||::|.||||.||:.|||||.::|.
Mouse   198 SPDGNRFATASADGQIFIYDGKTGEKVCALGESKAHDGGIYAISWSPDSTHLLSASGDKTSKIWD 262

  Fly   268 VESRELVSEFVMGTTVDDQQVSCLWQGDNLITVSLSGVITYLNVADPSKPLRVVKGHNKPITVLG 332
            |....:||.|.||:.|.|||:.||||.|:|:::||||.|.||:..:|||||||:|||:|.|..|.
Mouse   263 VNVNSVVSTFPMGSNVLDQQLGCLWQKDHLLSISLSGYINYLDKNNPSKPLRVIKGHSKSIQCLT 327

  Fly   333 L--SDDRSTIYTGSHDGVVTNWNSGSGTNDRITGTGHGNQINGIAA-WGDFVYTCGIDDSLRQFS 394
            :  :..:|.||:|||||.:..|:|.:|.||..:|.||.||::.:.. ..:.:.:|.:||::|..:
Mouse   328 VHRNGGKSYIYSGSHDGHINYWDSETGENDSFSGKGHTNQVSRMTVNESEQLVSCSMDDTVRYTN 392

  Fly   395 VEGNSYTDY-VVKLNCQPRGLAILRNENIIALACIKELTLVQDQKKIFSLPIK-YEASSIAVNAD 457
            :....|:.. ||||:.||:.:|: .......:.||.::.|::||||.||:... ||...:||:..
Mouse   393 LTLRDYSGQGVVKLDVQPKCVAV-GPGGYTVVVCIGQIVLLKDQKKCFSIDNPGYEPEVVAVHPG 456

  Fly   458 TSDVAVGGDDQKLHIY-----TLK--GGVLEPKVELDHLGAVTDVSYSPDLKYLVACDAHRKVVL 515
            ...|||||.|..:.:|     |||  |.:||.|      |.||||:||.|..:|..|||.:.|.:
Mouse   457 GDTVAVGGTDGNVRVYSILASTLKDEGKLLEAK------GPVTDVAYSHDGAFLAVCDASKVVTV 515

  Fly   516 YSVEEYKPAHNKEWGFHSARVNTVAWSPNSLLVASGSLDTTIIIWSVANPAKHTIIKNAHPQSQI 580
            :||.:....:|..:| |.|::..:||||::...|||.:|..:.:|::::|.....|::||....:
Mouse   516 FSVADGYSENNVFYG-HHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETKVKIQDAHRLHHV 579

  Fly   581 TRLVWLDNNTVISTGQDCNTKVWHV 605
            :.|.|||.:|:::|..|.:.|.|.:
Mouse   580 SSLAWLDEHTLVTTSHDASVKEWTI 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flr	NP_648642.1	WD40	26..557	CDD:225201	275/543 (51%)
		WD40	59..353	CDD:238121	176/296 (59%)
		WD40 repeat	68..106	CDD:293791	29/37 (78%)
		WD40 repeat	111..149	CDD:293791	24/37 (65%)
		WD40 repeat	156..192	CDD:293791	22/35 (63%)
		WD40 repeat	198..234	CDD:293791	18/35 (51%)
		WD40 repeat	242..278	CDD:293791	18/35 (51%)
		WD40 repeat	287..306	CDD:293791	11/18 (61%)
		WD40	317..607	CDD:295369	108/301 (36%)
		WD40 repeat	330..352	CDD:293791	9/23 (39%)
		WD40 repeat	372..407	CDD:293791	7/36 (19%)
		WD40 repeat	411..442	CDD:293791	9/30 (30%)
		WD40 repeat	450..485	CDD:293791	16/41 (39%)
		WD40 repeat	492..528	CDD:293791	15/35 (43%)
		WD40	520..>607	CDD:225201	26/86 (30%)
		WD40 repeat	536..573	CDD:293791	11/36 (31%)
		WD40 repeat	580..603	CDD:293791	8/22 (36%)
Wdr1	NP_035845.1	WD 1	4..45		22/40 (55%)
		WD 2	48..87		30/38 (79%)
		WD40	53..475	CDD:225201	218/422 (52%)
		WD40	54..389	CDD:238121	189/334 (57%)
		WD40 repeat	62..100	CDD:293791	29/37 (78%)
		WD 3	93..135		26/41 (63%)
		WD40 repeat	105..143	CDD:293791	24/37 (65%)
		WD 4	138..176		21/37 (57%)
		WD40 repeat	150..186	CDD:293791	22/35 (63%)
		WD 5	180..218		23/37 (62%)
		WD40 repeat	192..229	CDD:293791	18/36 (50%)
		WD 6	224..263		22/38 (58%)
		WD40	229..>604	CDD:225201	154/382 (40%)
		WD40 repeat	237..273	CDD:293791	18/35 (51%)
		WD 7	270..306		21/35 (60%)
		WD 8	311..351		20/39 (51%)
		WD40	312..602	CDD:295369	107/297 (36%)
		WD40 repeat	325..361	CDD:293791	14/35 (40%)
		WD 9	358..408		14/49 (29%)
		WD40 repeat	429..490	CDD:293791	25/66 (38%)
		WD 10	432..474		17/41 (41%)
		WD 11	480..518		18/43 (42%)
		WD40 repeat	493..528	CDD:293791	14/34 (41%)
		WD 12	523..561		13/38 (34%)
		WD40 repeat	535..572	CDD:293791	11/36 (31%)
		WD 13	566..604		12/37 (32%)
		WD40 repeat	579..604	CDD:293791	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847474
Domainoid	1	1.000	136	1.000	Domainoid score	I4916
eggNOG	1	0.900	-	-		E1_KOG0318
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6628
Inparanoid	1	1.050	581	1.000	Inparanoid score	I1013
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53916
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003250
OrthoInspector	1	1.000	-	-		oto92306
orthoMCL	1	0.900	-	-		OOG6_102813
Panther	1	1.100	-	-	LDO	PTHR19856
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1789
SonicParanoid	1	1.000	-	-		X2198
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790