DRSC/TRiP Functional Genomics Resources

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Protein Alignment flr and WDR90

DIOPT Version :9

Sequence 1:NP_648642.1 Gene:flr / 39505 FlyBaseID:FBgn0260049 Length:608 Species:Drosophila melanogaster
Sequence 2:XP_016878512.1 Gene:WDR90 / 197335 HGNCID:26960 Length:1838 Species:Homo sapiens


Alignment Length:659 Identity:127/659 - (19%)
Similarity:216/659 - (32%) Gaps:222/659 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 FLYTNGNSVIIRNIENPAIADVYTEHSCAVNVAKYSPSGFYIASGDASGK--------IRIWDTV 94
            |.||.|..|::.::.:.| ...::.||..::....|.|...:||  |||:        ||:||..
Human  1221 FAYTCGRLVVVEDLHSGA-QQHWSGHSAEISTLALSHSAQVLAS--ASGRSSTTAHCQIRVWDVS 1282

  Fly    95 NK--EHL--------LKNEFQP-------------------------------IAGPIKDISWSP 118
            ..  :||        |...|.|                               :..|:..::::|
Human  1283 GGLCQHLIFPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHGVAFNP 1347

  Fly   119 -DNQRIVAVGEGRERFGHVFMSETGTSV---------------GEISG-------------QSKS 154
             |...:..||:|...|.  .:.:.|..:               ||::.             .|..
Human  1348 WDAGELTCVGQGTVTFW--LLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQ 1410

  Fly   155 INSADFRPARPF------------------RIVTGSEDNTIAVF----------EGPPFKFKMTK 191
            :...|.|..|.|                  |:|:||....:.::          :|...:.....
Human  1411 VCVWDTRAGRCFLSWEADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSGARSSSVF 1475

  Fly   192 QDHSRFVQAVRYSPDGKFFASAGFDGKVFL---------------YDGTSSELVGEFGSPAHKGG 241
            .:|...:       ||. ..||.||..|.:               .:|||:.|:.     .|:..
Human  1476 MEHELVL-------DGA-VVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLIS-----GHRSK 1527

  Fly   242 VYALAWKPDSTQLLTCSGDKTCRLWTVESRELVSEFVMGTTVDDQQVSCL-WQ------------ 293
            |..:.:.|..:...|||.|.:.|:|.:.|.|||.:|    .|.:|...|| |.            
Human  1528 VNEVVFSPGESHCATCSEDGSVRVWALASMELVIQF----QVLNQSCLCLAWSPPCCGRPEQQRL 1588

  Fly   294 ----GDNLITVSLSGVITYLNVADPSKPLRVVKGHNKPI--TVLGLSDDRSTIYTGSHDGVVTNW 352
                ||.           .|.:...|:....:|.|..|:  |.:..|.|..|:.:|..||:|...
Human  1589 AAGYGDG-----------SLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVS 1642

  Fly   353 NSGSGTNDRITGTGHGNQINGI-------------------AAWGDFVYTCGIDDSLRQF----- 393
            :..:||..|:.....|..|:.|                   ||.||...:....|.||..     
Human  1643 HPCTGTTFRVLSDHQGAPISTICVTCKECEDLGVEGTDLWLAASGDQRVSVWASDWLRNHCELVD 1707

  Fly   394 --------SVEGNSYTDYVVKLNCQPRGLAIL------RNENIIALACIKELTLVQDQKKIFSLP 444
                    :.|...:....:...|...|..::      ..|.||...|.|::        :..:|
Human  1708 WLSFPMPATTETQGHLPPSLAAFCPWDGALLMYVGPGVYKEVIIYNLCQKQV--------VEKIP 1764

  Fly   445 IKYEASSIAVNADTSDVAVGGDDQKLHIYTLKGGVLEPKVELDHLGAVTDVSYSPDLKYLVACDA 509
            :.:.|.|::::..|..:|||..:..|.:.....|..:...  .|..||....::|..:.|... |
Human  1765 LPFFAMSLSLSPGTHLLAVGFAECMLRLVDCAMGTAQDFA--GHDNAVHLCRFTPSARLLFTA-A 1826

  Fly   510 HRKVVLYSV 518
            ..:::::.|
Human  1827 RNEILVWEV 1835

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
flrNP_648642.1 WD40 26..557 CDD:225201 127/659 (19%)
WD40 59..353 CDD:238121 84/433 (19%)
WD40 repeat 68..106 CDD:293791 15/55 (27%)
WD40 repeat 111..149 CDD:293791 9/53 (17%)
WD40 repeat 156..192 CDD:293791 9/63 (14%)
WD40 repeat 198..234 CDD:293791 11/50 (22%)
WD40 repeat 242..278 CDD:293791 12/35 (34%)
WD40 repeat 287..306 CDD:293791 5/35 (14%)
WD40 317..607 CDD:295369 48/242 (20%)
WD40 repeat 330..352 CDD:293791 7/21 (33%)
WD40 repeat 372..407 CDD:293791 9/66 (14%)
WD40 repeat 411..442 CDD:293791 6/36 (17%)
WD40 repeat 450..485 CDD:293791 7/34 (21%)
WD40 repeat 492..528 CDD:293791 5/27 (19%)
WD40 520..>607 CDD:225201
WD40 repeat 536..573 CDD:293791
WD40 repeat 580..603 CDD:293791
WDR90XP_016878512.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0318
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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