Protein Alignment flr and unc-78

DIOPT Version :10

• Sequence 1: NP_648642.1
• Gene: flr / 39505
• FlyBaseID: FBgn0260049
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_001024356.1
• Gene: unc-78 / 180631
• WormBaseID: WBGene00006810
• Length: 611
• Species: Caenorhabditis elegans
• Alignment Length: 604
• Identity: 250/604 - (41%)
• Similarity: 372/604 - (61%)
• Gaps: 15/604 - (2%)

  Fly    14 IYATLPRTQRGQPIVLGADPKGKNFLYTNGNSVIIRNIENPAIADVYTEHSCAVNVAKYSPSGFY 78
            ::.:||||.||..:|||..|.|....|.||.||....:.:....::|||||....|||.||||:|
 Worm     9 LFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYY 73

  Fly    79 IASGDASGKIRIWDTVNKEHLLKNEFQPIAGPIKDISWSPDNQRIVAVGEGRERFGHVFMSETGT 143
            .||||..|.:|||||....|:||......:||:|||||..:::||.|||||||||||||:.:|||
 Worm    74 CASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGT 138

  Fly   144 SVGEISGQSKSINSADFRPARPFRIVTGSEDNTIAVFEGPPFKFKMTKQDHSRFVQAVRYSPDGK 208
            |.|.::||::::||.||:|:|||||::||:|||:|:|||||||||.|..:|::||.:|||:|||.
 Worm   139 SNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGS 203

  Fly   209 FFASAGFDGKVFLYDGTSSELVGEF-----GSPAHKGGVYALAWKPDSTQLLTCSGDKTCRLWTV 268
            .|||.|.||.:.||:|......|.|     .:.||.|.|:.|.|.||.|::.:.|.|||.::|.|
 Worm   204 LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNV 268

  Fly   269 ESRELVSEFVMGTTVDDQQVSCLWQGDNLITVSLSGVITYLNVADPSKPLRVVKGHNKPITVLGL 333
            .:.::.....:||.::|||:..:|....|:::|.:|.|.::| .:.....:|..||||.||.|..
 Worm   269 ATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVN-PELGSIDQVRYGHNKAITALSS 332

  Fly   334 SDDRSTIYTGSHDGVVTNWNSGSGTNDRITGTGHGNQINGI--AAWGDFVYTCGIDDSLRQFSVE 396
            |.|..|:::...:|.:.:|:..:|.::|:....|...|.||  .:.|| ::|...||.|:.....
 Worm   333 SADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGD-LFTVSWDDHLKVVPAG 396

  Fly   397 G---NSYTDYVVKLNCQPRGLAILRNENIIALACIKELTLVQDQKKIFSLPIKYEASSIAVNADT 458
            |   :|......||:.||.|||:..:.:|...||.|.:. :....|:..:||.|.:|.:|::.|.
 Worm   397 GSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIA-IYSHGKLTEVPISYNSSCVALSNDK 460

  Fly   459 SDVAVGGDDQKLHIYTLKGGVLEPKVELDHLGAVTDVSYSPDLKYLVACDAHRKVVLYSV-EEYK 522
            ..|||||.|.|:|:|.|.|..:.....:.|...:|.|::|.:..:|||.|..|||:.||| ..::
 Worm   461 QFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFE 525

  Fly   523 PAHNKEWGFHSARVNTVAWSPNSLLVASGSLDTTIIIWSVANPAKH-TIIKNAHPQSQITRLVWL 586
            .||...|.||:|:|..|:|||:::.:|:||||.::|:|::..|:.| .|||.||..|.:..::||
 Worm   526 LAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWL 590

  Fly   587 DNNTVISTGQDCNTKVWHV 605
            :..|::|.|||.|.|.|:|
 Worm   591 NETTIVSAGQDSNIKFWNV 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
flr	NP_648642.1	WD40	16..397	CDD:441893	168/387 (43%)
		WD40 repeat	68..106	CDD:293791	21/37 (57%)
		WD40 repeat	111..149	CDD:293791	25/37 (68%)
		WD40 repeat	156..192	CDD:293791	26/35 (74%)
		WD40 repeat	198..234	CDD:293791	18/40 (45%)
		WD40 repeat	242..278	CDD:293791	12/35 (34%)
		WD40 repeat	287..306	CDD:293791	5/18 (28%)
		WD40 repeat	330..352	CDD:293791	5/21 (24%)
		WD40 repeat	372..407	CDD:293791	10/39 (26%)
		WD40 repeat	411..442	CDD:293791	9/30 (30%)
		WD40 repeat	450..485	CDD:293791	14/34 (41%)
		WD40	488..>607	CDD:475233	51/120 (43%)
		WD40 repeat	492..528	CDD:293791	15/36 (42%)
		WD40 repeat	536..573	CDD:293791	16/37 (43%)
		WD40 repeat	580..603	CDD:293791	9/22 (41%)
unc-78	NP_001024356.1	WD40 repeat	63..101	CDD:293791	21/37 (57%)
		WD40	68..610	CDD:441893	226/545 (41%)
		WD40 repeat	106..144	CDD:293791	25/37 (68%)
		WD40 repeat	151..187	CDD:293791	26/35 (74%)
		WD40 repeat	193..229	CDD:293791	17/35 (49%)
		WD40 repeat	242..278	CDD:293791	12/35 (34%)
		WD40 repeat	287..308	CDD:293791	6/20 (30%)
		WD40 repeat	327..363	CDD:293791	10/35 (29%)
		WD40 repeat	382..440	CDD:293791	17/58 (29%)
		WD40 repeat	447..525	CDD:293791	30/77 (39%)
		WD40 repeat	539..577	CDD:293791	16/37 (43%)
		WD40 repeat	584..607	CDD:293791	9/22 (41%)