DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10222 and GPN2

DIOPT Version :9

Sequence 1:	NP_001287060.1	Gene:	CG10222 / 39504	FlyBaseID:	FBgn0036356	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_060536.3	Gene:	GPN2 / 54707	HGNCID:	25513	Length:	310	Species:	Homo sapiens

Alignment Length:	287	Identity:	147/287 - (51%)
Similarity:	201/287 - (70%)	Gaps:	10/287 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PTQATVENPRYGQLIIGPPGSGKTTYCGEALKFYRELGRQVGVVNLDPANENMSYEPVLSVMELI 70
            ||.|      :||.:||||||||||||....:|.|.|||:|.|||||||||.:.||..:.|.||:
Human     6 PTTA------FGQAVIGPPGSGKTTYCLGMSEFLRALGRRVAVVNLDPANEGLPYECAVDVGELV 64

  Fly    71 TVEDCMEHLKLGPNGALMHCAEYLADHLEDWLLPALRKLSATYNYFLFDCPGQVELYTHHNAMAR 135
            .:.|.|:.|:|||||.|::|.|||..:| |||...|..|..  :||||||||||||.|||.|:..
Human    65 GLGDVMDALRLGPNGGLLYCMEYLEANL-DWLRAKLDPLRG--HYFLFDCPGQVELCTHHGALRS 126

  Fly   136 IFERLERERYSLVTVNLIDSHYCSEPAKFIATLLMALNTMLRMSLPHVNVLSKADLLKKHETKLH 200
            ||.::.:....|..|:|:|||||::|||||:.|..:|.|||.:.|||:|:|||.||: :|..||.
Human   127 IFSQMAQWDLRLTAVHLVDSHYCTDPAKFISVLCTSLATMLHVELPHINLLSKMDLI-EHYGKLA 190

  Fly   201 FNVDYYTDVLDLKYLLDKLDDDPAMRKYRKLNAAICSMVEDYALVSFQLLDVFSTDSMLRLRNHI 265
            ||:||||:||||.||||.|..||..|.||:||..:..::|||:||||..|::...:|:.|:...:
Human   191 FNLDYYTEVLDLSYLLDHLASDPFFRHYRQLNEKLVQLIEDYSLVSFIPLNIQDKESIQRVLQAV 255

  Fly   266 DKANGYVYKAGEEQTVNSLLACAVGAE 292
            ||||||.::|.|::::.::::.|:||:
Human   256 DKANGYCFRAQEQRSLEAMMSAAMGAD 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10222	NP_001287060.1	Gem1	19..193	CDD:224025	96/173 (55%)
CG10222	NP_001287060.1	ATP_bind_1	20..271	CDD:281079	135/250 (54%)
GPN2	NP_060536.3	Gem1	13..182	CDD:224025	94/171 (55%)
		ATP_bind_1	14..261	CDD:281079	135/250 (54%)
		Gly-Pro-Asn (GPN)-loop, involved in dimer interface. /evidence=ECO:0000250\|UniProtKB:Q9UYR9	76..78		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160334
Domainoid	1	1.000	268	1.000	Domainoid score	I1874
eggNOG	1	0.900	-	-		E2759_KOG1533
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7006
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2812
Isobase	1	0.950	-	0	Normalized mean entropy	S760
OMA	1	1.010	-	-		QHG54489
OrthoDB	1	1.010	-	-		D432496at33208
OrthoFinder	1	1.000	-	-		FOG0005210
OrthoInspector	1	1.000	-	-		oto88415
orthoMCL	1	0.900	-	-		OOG6_102415
Panther	1	1.100	-	-	LDO	PTHR21231
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R520
SonicParanoid	1	1.000	-	-		X3724
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750