DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Poc1 and WDR5a

DIOPT Version :9

Sequence 1:	NP_001261799.1	Gene:	Poc1 / 39502	FlyBaseID:	FBgn0036354	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_190535.1	Gene:	WDR5a / 824128	AraportID:	AT3G49660	Length:	317	Species:	Arabidopsis thaliana

Alignment Length:	295	Identity:	73/295 - (24%)
Similarity:	148/295 - (50%)	Gaps:	15/295 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TGHSGGITQLRFGPDGAQIATSSTDSTVILWNLNQ-----AARCIRFASHSAPVNGVAWSPKGNL 74
            |.|:..::.::|..||..:|::|.|.|:..:.:|.     |.....|..|...::.||:|.....
plant    21 TSHNRAVSSVKFSSDGRLLASASADKTIRTYTINTINDPIAEPVQEFTGHENGISDVAFSSDARF 85

  Fly    75 VASAGHDRTVKIWEPKLRGVSGEFVAHSKAVRSVDFDSTGHLMLTASDDKSAKIWRVARRQFVSS 139
            :.||..|:|:|:|:.:...:....:.|:.....|:|:...:::::.|.|::.:||.|...:.:..
plant    86 IVSASDDKTLKLWDVETGSLIKTLIGHTNYAFCVNFNPQSNMIVSGSFDETVRIWDVTTGKCLKV 150

  Fly   140 FAQQNNWVRSAKFSPNGKLVATASDDKSVRIYDVDSGECVRTFTEERAAPRQ-LAWHPWGNMLAV 203
            ....::.|.:..|:.:|.|:.::|.|...||:|..:|.||:|..::...|.. :.:.|.|..:.|
plant   151 LPAHSDPVTAVDFNRDGSLIVSSSYDGLCRIWDSGTGHCVKTLIDDENPPVSFVRFSPNGKFILV 215

  Fly   204 ALGCNRIKIFDVSGSQLLQLYVVHSAPVN-----DVAFH-PSGHFLLSGSDDRTIRILDLLEGRP 262
            ....|.::::::|.::.|:.|..|   ||     ..||. .:|..::|||:|..:.:.:|...:.
plant   216 GTLDNTLRLWNISSAKFLKTYTGH---VNAQYCISSAFSVTNGKRIVSGSEDNCVHMWELNSKKL 277

  Fly   263 IYTLTGHTDAVNAVAFSRDGDKFATGGSDRQLLVW 297
            :..|.|||:.|..||.....:..|:|..|:.:.:|
plant   278 LQKLEGHTETVMNVACHPTENLIASGSLDKTVRIW 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Poc1	NP_001261799.1	WD40	10..298	CDD:238121	73/295 (25%)
		WD40	14..388	CDD:225201	73/295 (25%)
		WD40 repeat	22..58	CDD:293791	10/40 (25%)
		WD40 repeat	63..99	CDD:293791	9/35 (26%)
		WD40 repeat	106..140	CDD:293791	7/33 (21%)
		WD40 repeat	147..183	CDD:293791	13/35 (37%)
		WD40 repeat	189..224	CDD:293791	7/35 (20%)
		WD40 repeat	231..254	CDD:293791	9/28 (32%)
		WD40 repeat	273..297	CDD:293791	6/23 (26%)
WDR5a	NP_190535.1	WD40	16..312	CDD:238121	72/293 (25%)
		WD40 repeat	27..69	CDD:293791	10/41 (24%)
		WD40 repeat	75..111	CDD:293791	9/35 (26%)
		WD40 repeat	116..152	CDD:293791	7/35 (20%)
		WD40 repeat	159..194	CDD:293791	12/34 (35%)
		WD40 repeat	201..237	CDD:293791	6/35 (17%)
		WD40 repeat	245..282	CDD:293791	8/36 (22%)
		WD40 repeat	288..312	CDD:293791	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920