DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Poc1 and Apaf1

DIOPT Version :9

Sequence 1:	NP_001261799.1	Gene:	Poc1 / 39502	FlyBaseID:	FBgn0036354	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_076469.1	Gene:	Apaf1 / 78963	RGDID:	620575	Length:	1249	Species:	Rattus norvegicus

Alignment Length:	402	Identity:	87/402 - (21%)
Similarity:	169/402 - (42%)	Gaps:	44/402 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 HSGGITQLRFGPDGAQIATSSTDSTVILWNLNQAARCIRFASHSAPVNGVAWSPKGNLVASAGHD 81
            |:..:....|..||.:||:...|.|:.::......:.:...:|...|...|:|...:.:|:...|
  Rat   614 HTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSVD 678

  Fly    82 RTVKIWEPKLRGVSGEFVAHSKAVRSVDF-DSTGHLML-TASDDKSAKIWRVARRQFVSSFAQQN 144
            :.||||:.....:...:..||:.|....| :.:.||:| |.|:|...|:|.:.:::..::.....
  Rat   679 KKVKIWDSGTGKLVHTYEEHSEQVNCCHFTNKSNHLLLATGSNDSFLKLWDLNQKECRNTMFGHT 743

  Fly   145 NWVRSAKFSPNGKLVATASDDKSVRIYDVDSG------ECVRTFTEERAAPRQL-------AWHP 196
            |.|...:|||:.:|:|:.|.|.:::::||.|.      ...|.|......|..:       :|..
  Rat   744 NSVTHCRFSPDDELLASCSADGTLKLWDVRSANEKKSINVKRFFLSSEDPPEDVEVIVKCCSWSA 808

  Fly   197 WGNMLAVALGCNRIKIFDVSGSQLL-QLYVVHSAPVNDVAFHPSGHFLLSGSDDRTIRILDLLEG 260
            .|:.:.|| ..|::.:.|:..|.|| :::..|.:.:....|.|..|..:.......:.:.::...
  Rat   809 DGDRIIVA-AKNKVLLLDIHTSGLLTEIHTGHHSTIQYCDFSPYDHLAVIALSQYCVELWNIDSR 872

  Fly   261 RPIYTLTGHTDAVNAVAFSRDGDKFATGGSDRQLLVWQSNLHTYDASQFEAKSALASSSCESSGV 325
            ..:....||...|:.|.||.||..|.|...|:.:.||::.                 ..|::|.:
  Rat   873 VKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWETR-----------------KVCKNSAI 920

  Fly   326 SSKQSEGSSTSKSNDLSIRIDPRQSLAYQLSEENFQVLDVSIESGSDLCSCSARLDEIS------ 384
            ..||.......::..:.:.:|..:.|  ||.......:|...|:....|..|..|:.::
  Rat   921 VLKQEIDVVFQENEMMVLAVDNIRGL--QLIAGKTGQIDYLPEAQVSCCCLSPHLEYVAFGDEEG 983

  Fly   385 --KLLDSIDERV 394
              |:::..:.||
  Rat   984 AIKIIELPNNRV 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Poc1	NP_001261799.1	WD40	10..298	CDD:238121	70/296 (24%)
		WD40	14..388	CDD:225201	85/394 (22%)
		WD40 repeat	22..58	CDD:293791	7/35 (20%)
		WD40 repeat	63..99	CDD:293791	9/35 (26%)
		WD40 repeat	106..140	CDD:293791	9/35 (26%)
		WD40 repeat	147..183	CDD:293791	12/41 (29%)
		WD40 repeat	189..224	CDD:293791	10/42 (24%)
		WD40 repeat	231..254	CDD:293791	3/22 (14%)
		WD40 repeat	273..297	CDD:293791	9/23 (39%)
Apaf1	NP_076469.1	CARD_APAF1	7..92	CDD:260034
		AAA_16	126..245	CDD:289934
		NB-ARC	129..414	CDD:279299
		WD40	<598..685	CDD:225201	17/70 (24%)
		WD40	607..910	CDD:238121	70/296 (24%)
		WD 1-1	613..652		8/37 (22%)
		WD40 repeat	623..655	CDD:293791	7/31 (23%)
		WD40	653..1038	CDD:225201	79/363 (22%)
		WD 1-2	655..694		10/38 (26%)
		WD40 repeat	661..697	CDD:293791	8/35 (23%)
		WD 1-3	697..738		12/40 (30%)
		WD40 repeat	702..740	CDD:293791	10/37 (27%)
		WD 1-4	741..780		12/38 (32%)
		WD40 repeat	747..789	CDD:293791	12/41 (29%)
		WD 1-5	796..837		9/41 (22%)
		WD40 repeat	801..837	CDD:293791	9/36 (25%)
		WD 1-6	838..877		4/38 (11%)
		WD40 repeat	843..882	CDD:293791	4/38 (11%)
		WD 1-7	880..910		12/29 (41%)
		WD40 repeat	885..909	CDD:293791	9/23 (39%)
		Interpropeller linker. /evidence=ECO:0000250	910..921		2/27 (7%)
		WD 2-1	922..958		6/37 (16%)
		WD 2-2	959..998		7/37 (19%)
		WD40	961..1235	CDD:238121	7/35 (20%)
		WD40	961..>1235	CDD:225201	7/35 (20%)
		WD40 repeat	964..1001	CDD:293791	6/32 (19%)
		WD 2-3	1001..1040
		WD40 repeat	1006..1030	CDD:293791
		WD 2-4	1042..1080
		WD40 repeat	1048..1082	CDD:293791
		WD 2-5	1083..1122
		WD40 repeat	1089..1124	CDD:293791
		WD 2-6	1125..1164
		WD40 repeat	1130..1174	CDD:293791
		WD 2-7	1176..1213
		WD40 repeat	1181..1203	CDD:293791
		WD 2-8	1214..1249
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910