DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Poc1 and wdr5

DIOPT Version :9

Sequence 1:	NP_001261799.1	Gene:	Poc1 / 39502	FlyBaseID:	FBgn0036354	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001011411.1	Gene:	wdr5 / 496891	XenbaseID:	XB-GENE-493883	Length:	334	Species:	Xenopus tropicalis

Alignment Length:	299	Identity:	82/299 - (27%)
Similarity:	152/299 - (50%)	Gaps:	16/299 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FT--GHSGGITQLRFGPDGAQIATSSTDSTVILWNLNQAARCIRFASHSAPVNGVAWSPKGNLVA 76
            ||  ||:..::.::|.|:|..:|:||.|..:.:|...........:.|...::.||||...||:.
Frog    39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103

  Fly    77 SAGHDRTVKIWEPK----LRGVSGEFVAHSKAVRSVDFDSTGHLMLTASDDKSAKIWRVARRQFV 137
            ||..|:|:|||:..    |:.:.|    ||..|...:|:...:|:::.|.|:|.:||.|...:.:
Frog   104 SASDDKTLKIWDVSSGKCLKTLKG----HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL 164

  Fly   138 SSFAQQNNWVRSAKFSPNGKLVATASDDKSVRIYDVDSGECVRTFTEERAAPRQ-LAWHPWGNML 201
            .:....::.|.:..|:.:|.|:.::|.|...||:|..||:|::|..::...|.. :.:.|.|..:
Frog   165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI 229

  Fly   202 AVALGCNRIKIFDVSGSQLLQLYVVHSAPVNDVAFHPS---GHFLLSGSDDRTIRILDLLEGRPI 263
            ..|...|.:|::|.|..:.|:.|..|......:..:.|   |.:::|||:|..:.|.:|.....:
Frog   230 LAATLDNTLKLWDYSKGKCLKTYTCHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEVV 294

  Fly   264 YTLTGHTDAVNAVAFSRDGDKFATGG--SDRQLLVWQSN 300
            ..|.||||.|.:.|.....:..|:..  :|:.:.:|:|:
Frog   295 QKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Poc1	NP_001261799.1	WD40	10..298	CDD:238121	80/295 (27%)
		WD40	14..388	CDD:225201	82/299 (27%)
		WD40 repeat	22..58	CDD:293791	8/35 (23%)
		WD40 repeat	63..99	CDD:293791	15/39 (38%)
		WD40 repeat	106..140	CDD:293791	8/33 (24%)
		WD40 repeat	147..183	CDD:293791	13/35 (37%)
		WD40 repeat	189..224	CDD:293791	9/35 (26%)
		WD40 repeat	231..254	CDD:293791	6/25 (24%)
		WD40 repeat	273..297	CDD:293791	4/25 (16%)
wdr5	NP_001011411.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		WD40	37..331	CDD:238121	80/295 (27%)
		WD 1	43..82		10/38 (26%)
		WD40 repeat	48..85	CDD:293791	8/36 (22%)
		WD 2	85..126		15/40 (38%)
		WD40 repeat	91..127	CDD:293791	14/35 (40%)
		WD 3	128..168		11/39 (28%)
		WD40 repeat	132..168	CDD:293791	9/35 (26%)
		WD 4	169..208		12/38 (32%)
		WD40 repeat	175..210	CDD:293791	12/34 (35%)
		WD 5	212..253		9/40 (23%)
		WD40 repeat	217..253	CDD:293791	8/35 (23%)
		WD 6	256..296		8/39 (21%)
		WD40 repeat	261..298	CDD:293791	8/36 (22%)
		WD 7	299..333		9/33 (27%)
		WD40 repeat	304..330	CDD:293791	4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920