DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Poc1 and FBXW8

DIOPT Version :9

Sequence 1:	NP_001261799.1	Gene:	Poc1 / 39502	FlyBaseID:	FBgn0036354	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_016874665.1	Gene:	FBXW8 / 26259	HGNCID:	13597	Length:	599	Species:	Homo sapiens

Alignment Length:	427	Identity:	83/427 - (19%)
Similarity:	154/427 - (36%)	Gaps:	86/427 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RDPALERHFTGHSGGITQLRFGPDGAQIATSSTDSTVI---------LWNLNQAARCIRFASHSA 61
            ::..|..::....|.:::|...||.......|.|..||         :|:.........|.....
Human   188 KEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESED 252

  Fly    62 PVNGVAWSP-------KGNLVASAGHDRTVKIWEPKLRGVSGEFVAHSKAVRSVDFDSTGHLMLT 119
            ..:.....|       ..:|..:|..|..:.||:  ||  :|::..|     ..:.|:....:..
Human   253 EEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWD--LR--TGKYPVH-----RFEHDARIQALAL 308

  Fly   120 ASDDKSAK----------------IWRVARRQFVSSFAQQNNWVRSAKFSPNGKLVATASDDKSV 168
            :.||.:..                .|::|....|....|....|...:..|  ..||.|.|
Human   309 SQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYP--VAVAAAGD---- 367

  Fly   169 RIYDVDSGECVRTFTEERAAP--------RQLAWHPWGNMLAVALGCNRIKIFDV-SGSQLLQL- 223
            .:|.:.:.:..||.......|        .|:|:...|  |......::|.::.: :|.:||:|
Human   368 LMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQG--LGWVYEGSKILVYSLEAGRRLLKLG 430

  Fly   224 YVVHSAPVNDVAFHPSGHFLLSGSDDRTIRILDLLEGRPIYTLTGHTDAVNAVAFSRDGDKFATG 288
            .|:......:::..|. :.::||:.|..:||.||..|....:|:.|...|:||  ..|..|..:|
Human   431 NVLRDFTCVNLSDSPP-NLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAV--QMDDWKIVSG 492

  Fly   289 GSDRQLLVWQSNL----------HTYDASQFEAKSALASSSCESSGVSSKQSEGSSTSKSNDLSI 343
            |.:..:.||...:          |......|.:.|.:.::....:.:.:...:..:|.:.:...|
Human   493 GEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLI 557

  Fly   344 RIDPRQSLAYQLSEENFQVLDVSIESGSDLC--SCSA 378
            |       ||:     |.|..::.:|...:|  ||.|
Human   558 R-------AYE-----FAVDQLAFQSPLPVCRSSCDA 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Poc1	NP_001261799.1	WD40	10..298	CDD:238121	67/329 (20%)
		WD40	14..388	CDD:225201	82/419 (20%)
		WD40 repeat	22..58	CDD:293791	9/44 (20%)
		WD40 repeat	63..99	CDD:293791	9/42 (21%)
		WD40 repeat	106..140	CDD:293791	6/49 (12%)
		WD40 repeat	147..183	CDD:293791	9/35 (26%)
		WD40 repeat	189..224	CDD:293791	10/44 (23%)
		WD40 repeat	231..254	CDD:293791	4/22 (18%)
		WD40 repeat	273..297	CDD:293791	7/23 (30%)
FBXW8	XP_016874665.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44019
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100