DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Poc1 and POC1A

DIOPT Version :9

Sequence 1:	NP_001261799.1	Gene:	Poc1 / 39502	FlyBaseID:	FBgn0036354	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_056241.3	Gene:	POC1A / 25886	HGNCID:	24488	Length:	407	Species:	Homo sapiens

Alignment Length:	396	Identity:	155/396 - (39%)
Similarity:	234/396 - (59%)	Gaps:	19/396 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DPALERHFTGHSGGITQLRFGPDGAQIATSSTDSTVILWNLNQAARCIRFASHSAPVNGVAWSPK 71
            ||:|||||.||...:|.:.|..:..|:|:.|.||.:::|::...:|..||..|...|..|.:||.
Human     8 DPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72

  Fly    72 GNLVASAGHDRTVKIWEPKLRGVSGEFVAHSKAVRSVDFDSTGHLMLTASDDKSAKIWRVARRQF 136
            |:|:||...|:||:||.|.::|.|..|.||:..||||.|.|.|...:||||||:.|:|...|::|
Human    73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137

  Fly   137 VSSFAQQNNWVRSAKFSPNGKLVATASDDKSVRIYDVDSGECVRTFTEERAAPRQLAWHPWGNML 201
            :.|.:|..||||.|||||:|:|:.:|||||:|:::|..|.|||.::.|.......:.:||.|..:
Human   138 LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCI 202

  Fly   202 AVALGCNRIKIFDVSGSQLLQLYVVHSAPVNDVAFHPSGHFLLSGSDDRTIRILDLLEGRPIYTL 266
            |.|...|.:|::||...:|||.|.:|||.||.::|||||::|::.|.|.|::||||:|||.:|||
Human   203 AAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 267

  Fly   267 TGHTDAVNAVAFSRDGDKFATGGSDRQLLVWQSNLHTYDASQF----EAKSALASSSCESSGVSS 327
            .||......|||||.|:.||:||||.|::||:||....|..:.    ...:.||||......|..
Human   268 HGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDF 332

  Fly   328 KQSEGSSTSKSNDLSIRIDPRQSLAYQLSEENFQVLDVSIESGSDLCSCSARLDEISKLLDSIDE 392
            ....|...|..   |::..|::.::..      |.|..::|      ....:||.:::.:..:::
Human   333 PVPPGRGRSVE---SVQSQPQEPVSVP------QTLTSTLE------HIVGQLDVLTQTVSILEQ 382

  Fly   393 RVRRLE 398
            |:...|
Human   383 RLTLTE 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Poc1	NP_001261799.1	WD40	10..298	CDD:238121	133/287 (46%)
		WD40	14..388	CDD:225201	147/377 (39%)
		WD40 repeat	22..58	CDD:293791	11/35 (31%)
		WD40 repeat	63..99	CDD:293791	16/35 (46%)
		WD40 repeat	106..140	CDD:293791	16/33 (48%)
		WD40 repeat	147..183	CDD:293791	20/35 (57%)
		WD40 repeat	189..224	CDD:293791	12/34 (35%)
		WD40 repeat	231..254	CDD:293791	11/22 (50%)
		WD40 repeat	273..297	CDD:293791	13/23 (57%)
POC1A	NP_056241.3	WD40	11..299	CDD:238121	133/287 (46%)
		WD 1	17..56		11/38 (29%)
		WD40 repeat	23..59	CDD:293791	11/35 (31%)
		WD 2	59..98		17/38 (45%)
		WD40 repeat	64..100	CDD:293791	16/35 (46%)
		WD 3	101..140		19/38 (50%)
		WD40 repeat	107..140	CDD:293791	16/32 (50%)
		WD 4	143..182		23/38 (61%)
		WD40 repeat	148..184	CDD:293791	20/35 (57%)
		WD 5	185..224		12/38 (32%)
		WD40 repeat	190..226	CDD:293791	12/35 (34%)
		WD 6	227..266		21/38 (55%)
		WD40 repeat	232..255	CDD:293791	11/22 (50%)
		WD 7	269..308		20/38 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158878
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CMZ3
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H51460
Inparanoid	1	1.050	289	1.000	Inparanoid score	I2824
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	1	1.010	-	-		D1196215at2759
OrthoFinder	1	1.000	-	-		FOG0003920
OrthoInspector	1	1.000	-	-		otm41699
orthoMCL	1	0.900	-	-		OOG6_103474
Panther	1	1.100	-	-	LDO	PTHR44019
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4724
SonicParanoid	1	1.000	-	-		X2699
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800