Protein Alignment Poc1 and NEDD1

DIOPT Version :10

• Sequence 1: NP_001261799.1
• Gene: Poc1 / 39502
• FlyBaseID: FBgn0036354
• Length: 403
• Species: Drosophila melanogaster
• Sequence 2: NP_001128647.1
• Gene: NEDD1 / 121441
• HGNCID: 7723
• Length: 667
• Species: Homo sapiens
• Alignment Length: 432
• Identity: 96/432 - (22%)
• Similarity: 160/432 - (37%)
• Gaps: 92/432 - (21%)

  Fly    13 HFTGHSGGITQ--LRFGPDGAQIATSSTDSTVILWNLNQAARCIRFASHSAP--VNGVAWSPKGN 73
            |||   |.:.|  |||...|..|.         :|:.:......:|..|::|  ::.:.||...|
Human     2 HFT---GAVMQENLRFASSGDDIK---------IWDASSMTLVDKFNPHTSPHGISSICWSSNNN 54

  Fly    74 LVASA-------------------------------------------GHDRTVKIWEPKLRGVS 95
            .:.:|                                           |.:.||.||:.|.:.|.
Human    55 FLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVNLNSTSMYLVSGGLNNTVNIWDLKSKRVH 119

  Fly    96 GEFVAHSKAVRSVDFDSTGHLMLTASDDKSAKIWRVARRQFVSSFAQ-QNNWVRSAKFSPNGK-L 158
            .....|...|..|.::.....:.:.|......:..|......:.|.. .|..||..|:|...| |
Human   120 RSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPFGHGSNQSVRHLKYSLFKKSL 184

  Fly   159 VATASDDKSVRIYDVDSGECVRTFTEERAAPRQ-LAWHPWGNMLAVALGCN-RIKIFDVSGSQLL 221
            :.:.||:..|.::||:|......|.....||.. :.:.|...:|.|.:|.: ||.::|.|..:|:
Human   185 LGSVSDNGIVTLWDVNSQSPYHNFDSVHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSKKLV 249

  Fly   222 QLYVVHSAPVNDVAFHPSGHFLLSGSDDRTIRILDL-LEGRPIYTLTGHTDAVNAVAFSRDGDKF 285
            :. :|...|:..|.|.|.|..|..||....|...|| :...|:.|::.|..:|..:||     ::
Human   250 KT-LVADTPLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAF-----QY 308

  Fly   286 ATGGSDRQLLVWQSNLHTYDASQFEAKSALASSSCESSGVSSKQSEGSSTSKSNDLSIRIDPRQS 350
            :|..:...|....||..| ..::.......||...::||:                 :|..|..|
Human   309 STVLTKSSLNKGCSNKPT-TVNKRSVNVNAASGGVQNSGI-----------------VREAPATS 355

  Fly   351 LAYQLSEENFQVL---DVSIESGSDLCSCSARLDEISKLLDS 389
            :|..|.:.....:   .|:::..:.| ..|...|.:||..||
Human   356 IATVLPQPMTSAMGKGTVAVQEKAGL-PRSINTDTLSKETDS 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Poc1	NP_001261799.1	WD40	<7..298	CDD:441893	76/336 (23%)
		WD40 repeat	22..58	CDD:293791	8/37 (22%)
		WD40 repeat	63..99	CDD:293791	11/78 (14%)
		WD40 repeat	106..140	CDD:293791	3/33 (9%)
		WD40 repeat	147..183	CDD:293791	12/36 (33%)
		WD40 repeat	189..224	CDD:293791	10/36 (28%)
		WD40 repeat	231..254	CDD:293791	8/22 (36%)
		WD40 repeat	273..297	CDD:293791	5/23 (22%)
NEDD1	NP_001128647.1	WD40	31..306	CDD:238121	61/275 (22%)
		WD40 repeat	44..81	CDD:293791	4/36 (11%)
		WD40 repeat	88..124	CDD:293791	7/35 (20%)
		WD40 repeat	130..167	CDD:293791	4/36 (11%)
		WD40 repeat	172..209	CDD:293791	12/36 (33%)
		WD40 repeat	217..253	CDD:293791	9/36 (25%)
		WD40 repeat	258..295	CDD:293791	12/36 (33%)