DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Poc1 and Poc1b

DIOPT Version :9

Sequence 1:	NP_001261799.1	Gene:	Poc1 / 39502	FlyBaseID:	FBgn0036354	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_002729827.2	Gene:	Poc1b / 100362836	RGDID:	2323942	Length:	477	Species:	Rattus norvegicus

Alignment Length:	402	Identity:	153/402 - (38%)
Similarity:	236/402 - (58%)	Gaps:	32/402 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DPALERHFTGHSGGITQLRFGPDGAQIATSSTDSTVILWNLNQAARCIRFASHSAPVNGVAWSPK 71
            ||.|||:|.||...||...|.|:..||||:|.|:.::||:|...||..|:..|...|..:.:||:
  Rat     7 DPILERYFKGHKAAITSADFSPNCKQIATASWDTFLMLWSLKPHARAYRYVGHKDVVTSLQFSPQ 71

  Fly    72 GNLVASAGHDRTVKIWEPKLRGVSGEFVAHSKAVRSVDFDSTGHLMLTASDDKSAKIWRVARRQF 136
            |||:|||..|:||::|....:|.|.||.||:..||||||.:.|..::|||:|||.|:|.:.|::|
  Rat    72 GNLLASASRDKTVRLWVLDRKGKSSEFKAHTAPVRSVDFSADGQFLVTASEDKSIKVWSMYRQRF 136

  Fly   137 VSSFAQQNNWVRSAKFSPNGKLVATASDDKSVRIYDVDSGECVRTFTEERAAPRQLAWHPWGNML 201
            :.|..:..:|||.|||||:|:|:.:.|:||:::|:|..|.:||..|::.......:.:.|.|..:
  Rat   137 LYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTSKQCVNNFSDSVGFANFVDFSPNGTCI 201

  Fly   202 AVALGCNRIKIFDVSGSQLLQLYVVHSAPVNDVAFHPSGHFLLSGSDDRTIRILDLLEGRPIYTL 266
            |.|...:.::|:|:..::|||.|.|||..||.::|||||:.|::.|.|.|::||||:|||.||||
  Rat   202 ASAGSDHAVRIWDIRMNRLLQHYQVHSCGVNCLSFHPSGNSLVTASSDGTVKILDLVEGRLIYTL 266

  Fly   267 TGHTDAVNAVAFSRDGDKFATGGSDRQLLVWQSN---LHTYDASQFEAKSALASSSCESSGVSSK 328
            .|||..|..|:||:||:.|.:||:|.|:|||:::   :|..|.|:...|.....:|.....:..:
  Rat   267 QGHTGPVFTVSFSKDGELFTSGGADAQVLVWRTSFNQVHYRDPSKRNLKRLHLEASPHLLDIYPR 331

  Fly   329 QSEGSSTSKSNDLSIRIDPRQSLAYQLSEENFQVLDV-SIES--------------GSDLC---- 374
            ...|....:.   :|.|:|:..: ..|...:..|:|| |.:|              |.|:|
  Rat   332 TPHGHEDKRE---TIEINPKLEV-MDLHSSSPPVVDVLSFDSTTTADSTCRAVPGKGEDICRYFL 392

  Fly   375 ------SCSARL 380
                  .||:.:
  Rat   393 NPLLMPECSSTI 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Poc1	NP_001261799.1	WD40	10..298	CDD:238121	130/287 (45%)
		WD40	14..388	CDD:225201	148/395 (37%)
		WD40 repeat	22..58	CDD:293791	15/35 (43%)
		WD40 repeat	63..99	CDD:293791	16/35 (46%)
		WD40 repeat	106..140	CDD:293791	16/33 (48%)
		WD40 repeat	147..183	CDD:293791	17/35 (49%)
		WD40 repeat	189..224	CDD:293791	9/34 (26%)
		WD40 repeat	231..254	CDD:293791	11/22 (50%)
		WD40 repeat	273..297	CDD:293791	12/23 (52%)
Poc1b	XP_002729827.2	WD40	10..298	CDD:238121	130/287 (45%)
		WD40	14..>300	CDD:225201	128/285 (45%)
		WD40 repeat	21..58	CDD:293791	16/36 (44%)
		WD40 repeat	64..100	CDD:293791	16/35 (46%)
		WD40 repeat	105..141	CDD:293791	18/35 (51%)
		WD40 repeat	148..183	CDD:293791	16/34 (47%)
		WD40 repeat	189..225	CDD:293791	9/35 (26%)
		WD40 repeat	231..267	CDD:293791	21/35 (60%)
		WD40 repeat	273..297	CDD:293791	12/23 (52%)
		Ribosomal_S10	<331..365	CDD:294222	7/37 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CMZ3
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	279	1.000	Inparanoid score	I2836
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1196215at2759
OrthoFinder	1	1.000	-	-		FOG0003920
OrthoInspector	1	1.000	-	-		otm45827
orthoMCL	1	0.900	-	-		OOG6_103474
Panther	1	1.100	-	-	O	PTHR44019
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2699
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830