DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ARHGAP6 and RhoGAP102A

DIOPT Version :9

Sequence 1:	NP_038286.2	Gene:	ARHGAP6 / 395	HGNCID:	676	Length:	974	Species:	Homo sapiens
Sequence 2:	NP_001245416.1	Gene:	RhoGAP102A / 43781	FlyBaseID:	FBgn0259216	Length:	1256	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	180/577 - (31%)
Similarity:	264/577 - (45%)	Gaps:	103/577 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   100 CSSFSTPSTPQEKSP----------SGSFHFDYEVPLGR---GGLKKSMAWDLPS-----VLAGP 146
            |:|..|..|...|..          |.|..|...:..|.   |....::...||.     ..|..
  Fly   574 CTSAPTSPTSHSKLEKAIRTSSGLLSSSSQFISNILHGHNNAGNQFNTLTDKLPDCNQSHATASM 638

Human   147 ASSRSASSILCSSGGGPNGIFASPRRWLQQRKFQSPPDSRGH-----PYVVWKSEGDFTWNSMSG 206
            ..|:|.|::         |.|.:.|.|..:.|.|   :.|.:     |.:.|.....|.|.|.||
  Fly   639 QKSKSLSNV---------GQFVAKRMWRSRSKSQ---NKRSYLKSSIPTLKWYPSEHFLWISESG 691

Human   207 RSVRLRSVPIQSLSELERARLQEVAFYQLQ-------QDCDLSCQ--ITIPKDGQKRKKSLRKKL 262
            .|.::....:..||::|...::..|..::|       :|..:|.|  ..:||     ||||....
  Fly   692 ESFQIVETNLTRLSKIESDIVKNFALEKIQELNIGNIEDLKISPQKRRCVPK-----KKSLTTSF 751

Human   263 DSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKLKQDLQRD-EQKDASDFVASLLPF--GNKRQN 324
            ...||:.:::          |.|.:........|::|.:|: ..:|.|.:  |||..  |:....
  Fly   752 FDNGKKDDQN----------PRSVLFGTSLECCLERDSKRNVTMEDRSKY--SLLSMFRGSGSTP 804

Human   325 KELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEA 389
            ..:...|.::.|....|::|....:.|.:  |..||:.|         |.|:.|.:|       :
  Fly   805 GSVLKLNDNVRSCESLPSKSLEYGSTELS--AYVRGSFS---------NISKPLASL-------S 851

Human   390 QSKKEKARDKKLSLNPIYRQ-----VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFD 449
            ||:.|   |.:|:....|::     ||..|::|..:||.:|||.||:|||.:|||||:|||||||
  Fly   852 QSENE---DTELNFVKAYQEHSQLMVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFD 913

Human   450 RGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLEPEE-QLGTLQLLIYLLPP 513
            :.|...:..:...||||.||||||||:|:|||...||..|:.|..:.... ||..:..||.|||.
  Fly   914 KDIYFGISVDTCPHDVATLLKEFLRDLPEPLLCNTLYLTFLKTQRIRNRRLQLEAISHLIRLLPI 978

Human   514 CNCDTLHRLLQFLSIVARHADDNISKDGQEVT-GNKMTSLNLATIFGPNLL---HKQKSSDKEFS 574
            .:.|||:.||.||:.||.|:||..|.:|..:| ||||.|.||||:|.||:|   |...|.|||
  Fly   979 PHRDTLYVLLVFLAKVAAHSDDIWSTEGCCLTLGNKMDSYNLATVFAPNILRSTHLTFSRDKE-- 1041

Human   575 VQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRK 631
                  .|.....|.||:.||.:||.:|.:..:|.|.:....||..|:.:..|:..|
  Fly  1042 ------QENMIDAINVVRTMINHYEEIFNISAELLNVIYTQALEACPEKLYELISTK 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP6	NP_038286.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..120		7/29 (24%)
		PBP_N	67..>121	CDD:293698	7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..361		7/38 (18%)
		SH3-binding	342..352		1/9 (11%)
		RhoGAP_ARHGAP6	402..608	CDD:239841	97/215 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..672
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..729
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..838
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	860..945
RhoGAP102A	NP_001245416.1	RhoGAP	874..1069	CDD:295372	96/202 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146971
Domainoid	1	1.000	143	1.000	Domainoid score	I4664
eggNOG	1	0.900	-	-		E1_KOG2710
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006356
OrthoInspector	1	1.000	-	-		otm42089
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12635
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6395
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.840