DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ARHGAP6 and cv-c

DIOPT Version :9

Sequence 1:	NP_038286.2	Gene:	ARHGAP6 / 395	HGNCID:	676	Length:	974	Species:	Homo sapiens
Sequence 2:	NP_001097786.1	Gene:	cv-c / 41749	FlyBaseID:	FBgn0285955	Length:	2351	Species:	Drosophila melanogaster

Alignment Length:	671	Identity:	150/671 - (22%)
Similarity:	255/671 - (38%)	Gaps:	159/671 - (23%)

- Green bases have known domain annotations that are detailed below.

Human     3 AQSLLHSVFSCSSPASSSAASAKGFSKRKLRQTRSLDPALIGGCGSDEAGAEGSARGATAGRLYS 67
            |::||..|.|..             |:|:.||.|  :..:|.|
  Fly  1560 AKALLRRVESIK-------------SRRRKRQNR--ENVVISG---------------------- 1587

Human    68 PS-LPAESLGPRLASSSRGPPPRATRLPPPGPLCSSFSTPSTP----QEKSPSGSFHFDYEVPLG 127
            |: |.....|.|  ||.|.|....:..|.|..|....:.|..|    ..|.||   |.|..:...
  Fly  1588 PTVLDLSQFGQR--SSLRKPDAVYSTPPSPSALSPMHTFPKAPFFGNDLKVPS---HSDNFLSPN 1647

Human   128 RGGLKKSMAWDLPSVLAGPASSRSASSILCSSGGGPNGIFASPRRWLQQRKFQSPPDSRGHPYVV 192
            |...|::           |.:.||..:       .|...|:||...|::.|   ..||..
  Fly  1648 RSSPKRT-----------PTTPRSMRT-------SPLHFFSSPMSQLKEGK---SDDSSS----- 1686

Human   193 WKSEGDFTWNSMSGRSVRLRSVPIQSLSELER-ARLQEVAFYQLQQDCDLSCQITIPKDGQKRKK 256
            :.|:..   .|.:|..:.||. |.::...|:| .::.::..:. ..:|....::.| ||......
  Fly  1687 YYSDSQ---ESSTGGKLSLRK-PSKARRFLQRTGKVDDIGAHS-DSECHQGRKLLI-KDANSNTT 1745

Human   257 SLR-KKLD-----SLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKLKQDLQRDEQKDASDFVASL 315
            .:: |||.     :|||:..|...|...:|               ..:...|.|.|:..|...:.
  Fly  1746 EVKVKKLTRGGSLNLGKDPKKRDGFRSSSF---------------RSRSTSRKEAKNDEDTAGAT 1795

Human   316 LPFGNKRQ------NKELSSSNSSL----SSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDL 370
            ...|:|||      :.::....:.:    .|....|.:..:...|..|..|.:...:...::..|
  Fly  1796 TNGGSKRQPVVRWHSFQMEERPNMIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTL 1860

Human   371 DDNQSRLL----EALQLSLPAEAQS-KKEKARDKKLSLNPIY-------RQVPRLVDSCCQHLEK 423
            ..:..|..    ......||...:. |....:|||:...|:.       :.:|..|.:..:.|:.
  Fly  1861 TGHMERYCPSHRSGWNWELPKFIKKIKMPDYKDKKVFGVPLLMILQRSGQTLPLAVRAAFRWLQL 1925

Human   424 HGLQTVGIFRVGSSKKRVRQLREEFD------RGIDV-SLEEEHSVHDVAALLKEFLRDMPDPLL 481
            :.|..|||||....|.|:.:|||:.:      ..:|| .|::   .:|||.:||::.|::|:.||
  Fly  1926 NALDQVGIFRKSGGKSRIMKLREQIEVTDSTAECMDVFDLQQ---AYDVADMLKQYFRELPESLL 1987

Human   482 TRELYTAFINTLL-LEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVT 545
            |.::...|:.... |..|.:|..:|..:.|||..|.:.|:.||:||:|||.::..
  Fly  1988 TTKMSETFVAIFQHLPAEVRLDAVQCAVLLLPDENREILYVLLEFLTIVAANSQQ---------- 2042

Human   546 GNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAE-------------ESTAIIAVVQKMIEN 597
             |:|||.||......::.|...|:... ||.:|.|.:             |:.|....:..|||:
  Fly  2043 -NQMTSNNLGVCLAQSIFHSSISTGSA-SVSASPRRKGKGSGMPDMKELAEAKASHECLSFMIEH 2105

Human   598 YEALFMVPPDLQNEVLISLLE 618
            |:.::....:..::...|.:|
  Fly  2106 YKQIYTAAKEKLSKCNFSYME 2126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP6	NP_038286.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..120		28/121 (23%)
		PBP_N	67..>121	CDD:293698	17/58 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..361		7/48 (15%)
		SH3-binding	342..352		1/9 (11%)
		RhoGAP_ARHGAP6	402..608	CDD:239841	63/233 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..672
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..729
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..838
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	860..945
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937
		RhoGAP_DLC1	1893..2116	CDD:239840	66/237 (28%)
		SRPBCC	2148..2343	CDD:301327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910