DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARHGAP6 and CdGAPr

DIOPT Version :9

Sequence 1:	NP_038286.2	Gene:	ARHGAP6 / 395	HGNCID:	676	Length:	974	Species:	Homo sapiens
Sequence 2:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster

Alignment Length:	1128	Identity:	246/1128 - (21%)
Similarity:	379/1128 - (33%)	Gaps:	339/1128 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    48 SDEAGAEGSARG---------------------------ATAGRLYSPSLPAESLGPRL------ 79
            |.|||..|...|                           |.:.:|....:||:|| |.|
  Fly    20 SAEAGGIGGVNGGPIACHASTDKDAQAPPLQFEMDAPAAAISAQLNFKIVPADSL-PGLSYQDMF 83

Human    80 -----------ASSSRGPPPRATRLPPPGPLCSSFSTPSTPQEKSPSGS-----------FHFDY 122
                       ::.|...||....:|||        .||......|..|           .||.|
  Fly    84 ASMNTSQISNASTESSCSPPIQGAVPPP--------KPSRHMAVQPLNSKSCRFPKLEECAHFHY 140

Human   123 E-VPLGRGGLKKSMAWDLPSVLAGPASSRSASSILCSSGGG--PNGIFAS-------------PR 171
            | |.||          .|...|....|....|||...|.||  |:....|             |:
  Fly   141 ERVQLG----------PLSVQLLDDKSEHMGSSIASQSLGGDLPHSSLRSFSPESCWFIIRVCPQ 195

Human   172 R---WLQQRKFQSPP--DSRGHPYVVWKSEGDFTWNSMSG-RSVRLRSVPIQSLSELERARLQEV 230
            |   :|.:|.|::..  |...|..|..:        .:|| |::...:..:.|.|::|.|..:.:
  Fly   196 RCEPFLIKRSFENMQLLDEMLHRCVYDR--------KISGLRNMEELAAELPSESDVEYAVAKYL 252

Human   231 -AFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAY 294
             .|.::..| .|:|. ||....|...|..|..|.....::..:...:..|:|:...|..|.|
  Fly   253 ERFSKIASD-SLTCG-TILTWLQLDNKGRRLPLADGETQRTINTPAVGAAYGVRRYQAQAPD--- 312

Human   295 KLKQDLQRDEQKDASDFVASL-LPF--------GNKRQ-NKELSSSNSSLSSTSETPNESTSPNT 349
                    :...:..|.::.: :|.        |.|.. .|.|........|...|..:....|.
  Fly   313 --------EINIEVGDMISVIDMPSPAESIWWRGKKSHLQKSLYEVGFFPQSCVATIGDKVPRNF 369

Human   350 PEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQ----- 409
            |.|||......|.....:............:..||.|:.          ::|..:.|||:
  Fly   370 PMPAPLVGHLDASPTKPVLRKHGKLIAFFRSFILSRPSR----------RRLKQSGIYRERVFNC 424

Human   410 ------------VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFD--RGIDV-SLEEE 459
                        :|.::.||.:.:|.:|: ..||:|:......:::||..||  |..|: :.|.:
  Fly   425 DLSEHLLNSGQDIPMVLRSCAEFIENYGV-IDGIYRLSGITSNIQRLRRAFDEERVPDLGNPEMK 488

Human   460 HSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLL---EPEEQLGTLQLLIYLLPPCNCDTLHR 521
            ..:|.|::|||.:.|::|:||.|.:||..|:..:.:   |.:|:|..::..:..|||.:..||..
  Fly   489 QDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMKETVLKLPPPHYRTLKY 553

Human   522 LLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTA 586
            |.:.|..|::|       .|:  ||  ||..|||.::.||||   :|...|....::.|.....|
  Fly   554 LAEHLYKVSQH-------HGR--TG--MTDKNLAIVWAPNLL---RSPALESGGVAALRGVGVQA 604

Human   587 IIAVVQKMIENYEALFMVPPD--LQNEVLISL-------------LETDPDVVDYLLRRKASQSS 636
            :  |.:.:|.|...:|....|  .::.::.|.             ||:..| .:.||..:..|..
  Fly   605 V--VTEYLIRNCHNIFDALDDHPARHSMVASATAAAANAAGGELRLESLTD-CESLLVEQREQDQ 666

Human   637 SPDMLQSEVSFSVGG-----------RHS-----------------STDSNKASS---------G 664
            |..:::...|.|.||           |||                 |..||.||:         |
  Fly   667 SLGVVERPKSLSTGGAKLISLEEAQERHSRVEGADLKQSLPISMLTSASSNAASNIGSYIEVGGG 731

Human   665 DISPYDNNSPVLS-ERSLLAMQEDAAPGGSEKLYRV-------PGQ---------------FMLV 706
            ..|..|....||| .||....:.|..|.......|.       |||               |:..
  Fly   732 PSSLPDKYHTVLSAPRSWQKRKPDKTPSWKSIFSRSQRQGNPDPGQKITTDVKDSVASRVSFVQA 796

Human   707 GHLSSSKSRESSPGPR-------LGKDLSEEPFDIWGTWHSTLKSGSKDPGMT-GSSGDIFESS- 762
            .|..:||.......|:       ...:...:|.|:      .::|.|.|...| |.|..:...|
  Fly   797 SHAHASKELTKHDKPKSIELLETTSNERDPKPMDL------CIRSNSIDSLRTVGHSRSVSHDSY 855

Human   763 -SLRAGP-------C-SLSQGNLSPNWPRWQGSP---AELDSDTQGARRTQAAAPATEGRAHPAV 815
             .|...|       | |.....|..|:.|.:...   :|.:|.....|..:...|...|.|...:
  Fly   856 FDLLQSPQRGHMTTCPSRELSELGLNFDREEPEMRIFSESESLVSSPRVGKENVPPASGSATRRI 920

Human   816 SRACSTPHVQVAGKAERPTARSEQYLTLSGAHDLSESELDVAGLQSRATPQCQRPHGSGRDDKRP 880
            .||             ||...|.|..:::.: ...:..|::....|..|              .|
  Fly   921 MRA-------------RPEDFSSQTNSVNPS-PKKQPRLNLLSPSSART--------------MP 957

Human   881 PPPYPGPGKPAAAAAW--------------------IQ----GPPEGVETPTDQGGQAAE----- 916
            |||...||..:::...                    ||    |.||.|.| |.|...:.|
  Fly   958 PPPLSAPGTASSSCGHESGGAENCCKRYKLEDQLCDIQFIDCGTPENVPT-TQQQFASVEVHPPP 1021

Human   917 REQQVTQKKLSSANSLPAGEQDS 939
            :..:..|..:||:|....|...|
  Fly  1022 KPARANQSPISSSNGASVGSSSS 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP6	NP_038286.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..120		24/126 (19%)
		PBP_N	67..>121	CDD:293698	17/81 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..361		9/39 (23%)
		SH3-binding	342..352		2/9 (22%)
		RhoGAP_ARHGAP6	402..608	CDD:239841	64/230 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..672		15/69 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..729		3/26 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..838		24/109 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	860..945		24/109 (22%)
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	26/115 (23%)
		SH3_ARHGAP32_33	299..358	CDD:212769	12/69 (17%)
		RhoGAP_CdGAP	420..613	CDD:239849	58/209 (28%)
		FliJ	1322..1457	CDD:304890
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910