DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ARHGAP6 and conu

DIOPT Version :9

Sequence 1:	NP_038286.2	Gene:	ARHGAP6 / 395	HGNCID:	676	Length:	974	Species:	Homo sapiens
Sequence 2:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster

Alignment Length:	611	Identity:	135/611 - (22%)
Similarity:	232/611 - (37%)	Gaps:	143/611 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   105 TPSTPQEKSPSGSFHFDYE-----------VPLGRGGLKKSMAW---DLPSVLAGPASSRSASSI 155
            |.|.|:.|........:::           .|.....|:...||   .||: ........:.::|
  Fly   100 TKSRPKRKPDIRDVFREFDEQGTVTRSRSATPDSLDSLQIDEAWTNNSLPT-FVNVYEKNTETAI 163

Human   156 LCSSGGGPNGIFASPRRWLQQ--RKFQSPPDSRGHPYVVWKSEGDFTWNSMSGRSVRLRSVPIQS 218
            .|        :..|...:|:|  |:..|.|...|....:::           |..||. .:|:.|
  Fly   164 QC--------VEQSNEIYLKQNLRRTPSAPPKSGTYADIFR-----------GSQVRC-DIPLYS 208

Human   219 LSELE---RARLQEVAFYQLQQDCDLSCQITIPK------DGQKRKKSLRKKLDSLGKEKNKDKE 274
            ...:|   .:|:..:.|.:.:...|..|.|...|      |.:.:||   |..:.|...:|:...
  Fly   209 ADGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKESRSENDARSQKK---KSSEVLSASENECGR 270

Human   275 FIPQAFGMPLSQVIANDRAYKLKQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSE 339
            .:|..:.:...:.|..|     ...|...|..|..|..::|.               :.:...||
  Fly   271 LLPMPYNVLSFESICRD-----SSSLDSCEVLDTCDIPSTLF---------------TDVVLISE 315

Human   340 TPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKL--- 401
            |..:             |.:..:.::..|..|.|        ::||......|:.:..:..|
  Fly   316 TDMK-------------RLQTILWLELATIFDRN--------KVSLDKRKPFKRRRKEEGNLFGV 359

Human   402 SLNPIYRQ-----------VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR----- 450
            |:|.:.|:           ||..::.....|.:.|.:..|:.|:|..|::...|..|.:.
  Fly   360 SINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQN 424

Human   451 --GIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPP 513
              .:| :|....:||::::|||.:||::|.||||.||...|.....|...:|:..|.:|.:||||
  Fly   425 PDNLD-NLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSIDQMNALSILCHLLPP 488

Human   514 CNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATI-----FGPNLLHKQKSSDKEF 573
            .|.:||..||.|.:|:....|.           |||...|:|||     |.|..:|...::....
  Fly   489 ENRNTLRSLLSFFNIIINLKDI-----------NKMNVHNVATIMAPSMFPPRYIHPSDNNSIAE 542

Human   574 SVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQ-SSS 637
            .|:.:|:....|.|      :|...|.||.||    |.:::...:|......:...|.::: ::.
  Fly   543 QVRMAAQCCRLTNI------LILRGEKLFQVP----NNLIVESQKTMMGKKGWHRHRNSNEITAK 597

Human   638 PDMLQSEVSFSVGGRHSSTDSNKASS 663
            |    |..:.:||..|.||..||.|:
  Fly   598 P----SGKASNVGVGHDSTVINKYST 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP6	NP_038286.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..120		4/14 (29%)
		PBP_N	67..>121	CDD:293698	4/15 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..361		4/38 (11%)
		SH3-binding	342..352		0/9 (0%)
		RhoGAP_ARHGAP6	402..608	CDD:239841	66/228 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..672		9/25 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..729
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..838
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	860..945
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	68/241 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910