DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARHGAP6 and RhoGAP19D

DIOPT Version :9

Sequence 1:	NP_038286.2	Gene:	ARHGAP6 / 395	HGNCID:	676	Length:	974	Species:	Homo sapiens
Sequence 2:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster

Alignment Length:	1294	Identity:	251/1294 - (19%)
Similarity:	414/1294 - (31%)	Gaps:	479/1294 - (37%)

- Green bases have known domain annotations that are detailed below.

Human     9 SVFSCSSPASSSAA----SAKGFSKRKLRQTRSLDPALIGGCGSDE------------------- 50
            ||.:.:..|.||||    ||.| |...:|:.:.|..:     ..||
  Fly   734 SVATLADIAESSAAAIVDSASG-SGNVVRRYKPLSSS-----SFDEGKPMRRISYLRATNNETDF 792

Human    51 -----AGAEGSARGATAGRLYSPSLPAESLGPRLASSSRGPPPRATRLPPPGPLCSSFSTP---- 106
                 ||.:.:|.||:.        ||.:   ..|||:.||.|.:...|.|.|.....|.|
  Fly   793 NAEAAAGGDAAATGASG--------PASA---SAASSAPGPTPSSAPAPAPAPAPLPISIPIPVA 846

Human   107 --STPQ------EKSP---------SGSFHFDYEVPLG--------RGGLKKSMAWDLPSVLAGP 146
              ..||      |:.|         :|..|...|.|.|        .|..:.||:.|:
  Fly   847 AVVEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPNGLEDVRLSAHGSRRASMSSDM------- 904

Human   147 ASSRSASSILCSSGGG--PNGIFASPRRWLQQRKFQSPPD--------SRGHPYVVWKS-----E 196
               ||:..|.....|.  ||.:.|          |::..:        .|...|..|:.     :
  Fly   905 ---RSSIHIDAELNGKYVPNELEA----------FETEIEIKSSCINGKRMSEYRSWRQVKLEIK 956

Human   197 GDFTWNSMSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKK 261
            ||.. ...|||..:..    .::.||:   ::...|:....|              |:|..:|.:
  Fly   957 GDLL-RIYSGRHAKSE----HNVIELD---IRNFKFFDESMD--------------KKKYLIRMQ 999

Human   262 ---------LDSLGKEKNKDK---EFIPQAFGMPLSQVIAN--------------------DRAY 294
                     |.|||.|.|.|:   :.:..:.....::..||                    :..:
  Fly  1000 SKPSPSGAHLASLGNELNLDEGHDKLLTSSGSSSANEPAANAASALTASTSSSTCSSGPYTEILF 1064

Human   295 KLKQDLQRD------EQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPA 353
            |.|...:..      :.||:.::..:    .::.|.|:|:....:::|.|...:.....:..:.:
  Fly  1065 KTKSSNEMKRLFGLLQWKDSLNYDDN----EHQPQGKQLAEPQKTVASASYLDDVQGGASAADSS 1125

Human   354 PRARRRG---------------------AMSVDSIT-----------------DLDDNQSRLLEA 380
            |.:...|                     |.:.|||:                 ||...:|:..:.
  Fly  1126 PLSSHSGGIADASGSHHVSALPAAAAIVAATSDSISPVMKARKSSSHKHIPDKDLGSPKSKNWKD 1190

Human   381 L---------------QLSLPAEAQSKKEKARDKKLSLNPIYR---QVPRLVDSCCQHLEKHGLQ 427
            |               .|:.|:...:|:..:....|...|:.:   .||.||:.|...:|..||.
  Fly  1191 LLFRRGGSGSGGVSHHDLASPSACAAKQIGSIGVPLRSCPMSKVNAYVPHLVEVCTNIVETKGLG 1255

Human   428 TVGIFRVGSSKKRVRQLRE-----EFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYT 487
            .|||:|:..:|..:.:|.|     :|......|.:....|:.|::|||.|:|.:||.|:....|.
  Fly  1256 VVGIYRIPGNKAAISELSELVNTKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYI 1320

Human   488 AFINTLLLEPEEQLG-----TLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGN 547
            .||     |.:::.|     .|:.::..||....:|:..|::.|..|:.:.|           .|
  Fly  1321 NFI-----EADKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCD-----------VN 1369

Human   548 KMTSLNLATIFGPN--------------------------------------------------- 561
            :|...|||.||||:
  Fly  1370 RMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQCRIVELLVTQYDYFFEGGSLPDIAEVSGGTAA 1434

Human   562 -----------------LLH-----------------------KQKSSDKEFSVQS--------- 577
                             |||                       ::|:..|..:|.|
  Fly  1435 VSAAQPQQQTQEDQTSMLLHNLSKIERITERETTRTSRFMPQLRRKTHGKRSAVNSDTYSGESVL 1499

Human   578 -------------------SARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDV 623
                               |:.:..:|....:....|:...|.......:.::.||.||.|....
  Fly  1500 VSGSSSNTTTTTTTTTHTTSSTSSSNTITTTISTTTIQQRRAQRKAVQSICDQALILLLPTPVSS 1564

Human   624 V-------DYLLRRKASQSSSPDMLQSEVSFSV---GGRHSSTDSNKASSGDISPYDNNSPVLSE 678
            |       || .:..||.|:|.....|..|.|.   ||:.|::    :||...:.:.::|.....
  Fly  1565 VSLPFQSLDY-AKASASASASASSTASTSSSSTLHSGGKASAS----SSSSSTTKFSSSSSSACS 1624

Human   679 RSLLAMQEDAAPGGSEKL-----YRVPGQFMLVGHLSSSKSRESS------------------PG 720
            .:.:|:....:...|:.|     .|..|.|:  |..||.::|::|                  .|
  Fly  1625 TTAVAISSSISATSSKLLSANFKKRSTGGFL--GSRSSHQTRKASLDEKDSGQSSGSLGHSLGVG 1687

Human   721 PRLGKDLSEEPFDIWGTWHSTLKSGSKDPGMTGSSG--------DIFESS--SLRAGPCSLSQGN 775
            ..|.|:......||     |.|.:..........:|        |..:|.  :||:|..| :..|
  Fly  1688 INLAKEQQRSSVDI-----SILLTDDDSSSRLSDTGSMSLTTITDTLDSKLRNLRSGSES-NDEN 1746

Human   776 LSPNWPRWQ----GSPAELDSDT-----QGARRT--QAAAPATEGRAHPAVSRACSTPHVQVAGK 829
            .||.:|:.:    |.|..:.|:.     :...|.  |...|.........:||:|:.  ....|.
  Fly  1747 GSPEFPKNRRHTLGQPLHMHSENIPYADESPERLFHQFCNPLETAPLSLHLSRSCTA--TNTIGG 1809

Human   830 AERPTARSEQYLTLSGAHDLSESELDVA-GLQSRATPQCQRPHGSGRDDKRPPPPYPGPGKPAAA 893
            .|:|:.:|      .|...|..|.|..| .||..||                .|.:.|     ::
  Fly  1810 DEKPSKQS------GGVAPLPPSLLKAAHKLQHSAT----------------VPIHQG-----SS 1847

Human   894 AAWIQGPPEGVETPTDQGGQAAEREQQVTQKKLSSANSLPAGEQDSPRLGDAGWLDWQR 952
            .|...|....|.|||..||..|      ...:.||::.....:...||.  :.:|.::|
  Fly  1848 TAPTSGAATPVGTPTGSGGAGA------IPSRSSSSSVTTLTKSIQPRF--SNYLSYER 1898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP6	NP_038286.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..120		38/159 (24%)
		PBP_N	67..>121	CDD:293698	19/74 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..361		7/59 (12%)
		SH3-binding	342..352		0/9 (0%)
		RhoGAP_ARHGAP6	402..608	CDD:239841	61/337 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..672		8/35 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..729		7/37 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..838		24/116 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	860..945		18/84 (21%)
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	51/211 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910