DRSC/TRiP Functional Genomics Resources

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Protein Alignment ARHGAP6 and RhoGAP5A

DIOPT Version :9

Sequence 1:NP_038286.2 Gene:ARHGAP6 / 395 HGNCID:676 Length:974 Species:Homo sapiens
Sequence 2:NP_727007.1 Gene:RhoGAP5A / 31473 FlyBaseID:FBgn0029778 Length:494 Species:Drosophila melanogaster


Alignment Length:565 Identity:116/565 - (20%)
Similarity:200/565 - (35%) Gaps:122/565 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    45 GCGSDEAGAEGSARGATAGRLYSPSLPAESL-GPRLAS-SSRGPPPRATRLPPPGPLCSSFSTPS 107
            |.|:...|..|...||.     .||.|.:.: .|.|.. ....|.|...|.....||..:.||..
  Fly     8 GAGNANTGGSGGVGGAP-----EPSSPVQKVWKPELYKLQLEAPAPCPLRCQRTLPLPPAKSTAE 67

Human   108 TPQEKSPSGSFH-FDYEVPLGRGGLKKSMAWDLPSVLAGPASSRSASSILCSSGGGPNGIFASPR 171
            ..:..:.:|..: .:|...:|.                     ..|..:|.::..|...:..||:
  Fly    68 AVEANNLAGRLYGSEYHGLMGH---------------------LEAEQLLANARDGSYFVRRSPQ 111

Human   172 R---WLQQRKFQSPPDSRGHPYVVWK---------------SEGDFTWNSMSGRSVRLRSVPIQS 218
            .   :....:|...|.   |..:::|               :..|...:.:....::|.:.||  
  Fly   112 SDGYYTLSLRFNKRPK---HYKLLYKPGVGHYLRGQDKRFDTVHDMVADGLINFHMQLHASPI-- 171

Human   219 LSELERARLQEVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMP 283
               :::...|....||......|:.:.......:..|.:.::..:|..:||.:.:|..|.....|
  Fly   172 ---IQQINQQTKNCYQQSPYMTLNGRKLRALSNELGKAAAKESKESPAEEKEQKQEEPPPPAVDP 233

Human   284 LSQVIANDRAYKLKQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSN-SSLSSTSE-TPNESTS 346
            :..|......:|    :...:..:..:|.|:.| :|...|..:..:.. .:.|..|| .|     
  Fly   234 MPLVYEKPHHFK----VHTFKGLNWCEFCANFL-WGFTAQGVKCEACGFVAHSKCSELVP----- 288

Human   347 PNTPEPAPRARR-RGAMSVDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQV 410
               |:..|..:| ||....|..|                               .:.|.| :.|:
  Fly   289 ---PKCVPDLKRIRGVFGTDLTT-------------------------------MVQLEP-HHQI 318

Human   411 PRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR---GIDVSLEEEHSVHDVAALLKEF 472
            |.:|..|.:.:|..|:...||:||......:..|:...||   ..|:|.....:|:.:|..||.:
  Fly   319 PFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAGTLKLY 383

Human   473 LRDMPDPLLTRELYTAFINT-LLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDN 536
            ||.:|.||:|.:.|.:|:.. ...:..||...:...:..|||.:...|..:|:.|..||.|    
  Fly   384 LRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASH---- 444

Human   537 ISKDGQEVTGNKMTSLNLATIFGPNLL----HKQKSSDKEFSVQS 577
                   ...|||...||||:|.|.|:    |....:::.|.:.|
  Fly   445 -------YAVNKMNEHNLATVFAPTLIATPQHMTNLTEEIFMLSS 482

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ARHGAP6NP_038286.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..120 19/77 (25%)
PBP_N 67..>121 CDD:293698 13/56 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..361 9/41 (22%)
SH3-binding 342..352 1/9 (11%)
RhoGAP_ARHGAP6 402..608 CDD:239841 53/184 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..672
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 709..729
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 742..838
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 860..945
RhoGAP5ANP_727007.1 SH2_a2chimerin_b2chimerin 75..166 CDD:198215 13/114 (11%)
C1_1 242..294 CDD:278556 11/64 (17%)
RhoGAP_chimaerin 302..491 CDD:239837 55/224 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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