DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ARHGAP6 and RacGAP84C

DIOPT Version :9

Sequence 1:	NP_038286.2	Gene:	ARHGAP6 / 395	HGNCID:	676	Length:	974	Species:	Homo sapiens
Sequence 2:	NP_476704.1	Gene:	RacGAP84C / 117503	FlyBaseID:	FBgn0045843	Length:	384	Species:	Drosophila melanogaster

Alignment Length:	260	Identity:	60/260 - (23%)
Similarity:	102/260 - (39%)	Gaps:	66/260 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   410 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLR 474
            ||.|:..|...:|..|||..|::||.|::::.::||.:..||...........|.:...:|:|||
  Fly   160 VPALIVHCVTEIEARGLQQEGLYRVSSTREKCKRLRRKLLRGKSTPHLGNKDTHTLCCCVKDFLR 224

Human   475 DMPDPLL----TRELYTAFINTLLLEPEEQLGTLQLLIYL----LPPCNCDTLHRLLQFLSIVAR 531
            .:..||:    .|:...|      ...|::| .:::.:||    |...:.|||..|:.....:|
  Fly   225 QLVHPLIPIYHRRDFEEA------TRHEDRL-AVEMAVYLAVLELHQAHRDTLAYLMLHWQKIA- 281

Human   532 HADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIE 596
                       |....:||..|||.||.|.|.     .|.:.::::          :...|:::
  Fly   282 -----------ESPAVRMTVNNLAVIFAPTLF-----GDLDLTLEN----------VVTWQRVL- 319

Human   597 NYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFS--VGGRHSSTDSN 659
              :.|.::|....::    .||..|               .|..|.|...|.  ...||..:.||
  Fly   320 --KVLLLMPAGFWSQ----FLEVHP---------------LPTSLGSTYDFEDRYNHRHWDSSSN 363

Human 660 659
Fly 364 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP6	NP_038286.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..120
		PBP_N	67..>121	CDD:293698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..361
		SH3-binding	342..352
		RhoGAP_ARHGAP6	402..608	CDD:239841	49/205 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..672		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..729
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..838
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	860..945
RacGAP84C	NP_476704.1	C1_1	87..139	CDD:278556
RacGAP84C	NP_476704.1	RhoGAP_MgcRacGAP	142..330	CDD:239847	49/206 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910