Protein Alignment CG17687 and CFAP43

DIOPT Version :10

• Sequence 1: NP_001368937.1
• Gene: CG17687 / 39495
• FlyBaseID: FBgn0036348
• Length: 1594
• Species: Drosophila melanogaster
• Sequence 2: NP_079421.5
• Gene: CFAP43 / 80217
• HGNCID: 26684
• Length: 1665
• Species: Homo sapiens
• Alignment Length: 1830
• Identity: 372/1830 - (20%)
• Similarity: 691/1830 - (37%)
• Gaps: 448/1830 - (24%)

  Fly     6 TVCWCNIWDKDTLVNVGPDVLCQRNGNAMKFVHMQTKAVTFFKAETVSTGL---SISCFAGHNRF 67
            :|.|...:.|..:..|..:.:|...||.:.|::::||..|..:......|:   :|.|
Human    20 SVRWVQGFPKQNVHFVNDNTICYPCGNYVIFINIETKKKTVLQCSNGIVGVMATNIPC------- 77

  Fly    68 PLFAFAEVVLRPNIYIYRYPDMAKFSSIPPH-MMSYTDIRFSELDLLIA-VGGYPDYCLCVFNYR 130
            .:.||::..|:|.||:|.:|.:.:.:.:..: ::.||.:.||.....:| ....|::.|.::|:.
Human    78 EVVAFSDRKLKPLIYVYSFPGLTRRTKLKGNILLDYTLLSFSYCGTYLASYSSLPEFELALWNWE 142

  Fly   131 TGTLV---------LEQFTNVPTVERGIVISFTSLPSI--IQLNKQDMTIICYEICTV----EKE 180
            :..::         :.|.:..|...|.:.:|..|..|:  |:.:.|:.   |:...:|    |..
Human   143 SSIILCKKSQPGMDVNQMSFNPMNWRQLCLSSPSTVSVWTIERSNQEH---CFRARSVKLPLEDG 204

  Fly   181 SFLYKVAEVELGKKFLKSCNRCLSFG--------------EDNTLYATNDFGHLLSVDVACFALK 231
            ||..:...|     |.:|..:.|.:|              |..|....:|...||...:.|
Human   205 SFFNETDVV-----FPQSLPKDLIYGPVLPLSAIAGLVGKEAETFRPKDDLYPLLHPTMHC---- 260

  Fly   232 PQWQPTSE--------------SDS--VTEMEKMPRSH-----------GLTYHKSGFL---IWN 266
              |.|||:              .|:  ||.:.|:....           .|.|.|.|.|   |..
Human   261 --WTPTSDLYIGCEEGHLLMINGDTLQVTVLNKIEEESPLDRRNFISPVTLVYQKEGVLASGIDG 323

  Fly   267 STTAYYVKKKAGVFKLEWEFEGRL-------NEVVRFLSNNNGEIYA---ERRPGHIDQVVVDRN 321
            ...::.:|.::.:.:...|.|..:       |..|..:..:.|.:|.   .:.| .:::|:...:
Human   324 FVYSFIIKDRSYMIEDFLEIERPVEHMTFSPNYTVLLIQTDKGSVYIYTFGKEP-TLNKVLDACD 387

  Fly   322 GTV-SLEAVVPTGKPVITFR-----VVQGLKDECVCVLHDEGVAMMDLAKGNTLCEVSVPGATAM 380
            |.. :::.:.|..:..:|..     .|..|:| |.||   ..:.:..||.....|..|:..|
Human   388 GKFQAIDFITPGTQYFMTLTYSGEICVWWLED-CACV---SKIYLNTLATVLACCPSSLSAA--- 445

  Fly   381 CNHRSLALVVVGTLDASIVLI--------------HFERASLPHVLCD-----LKMETAA----V 422
                      |||.|.|:..|              ....:|:.||:.|     |.:.||.    :
Human   446 ----------VGTEDGSVYFISVYDKESPQVVHKAFLSESSVQHVVYDQQGIFLLVGTAEGKVFI 500

  Fly   423 VGIEFNDSWVV--FQDQMK--------------VLHVVQVDNRPHKLTHYFEMNP-----PELSQ 466
            :....:.|:.:  |.:..|              ::.|:.:.:.|.......||..     |::|.
Human   501 INANSSSSFQIIGFTEVAKDILQISTVSLLETDIVEVMVLSSLPEAGRSRLEMFTLPTLLPQVST 565

  Fly   467 VF-----------IHTFLLADGPRLMVFINRDHSMKRPGFATEL-WLYNWGKDKRLHRREYIL-- 517
            .|           ||.:|......|...:....|.:..||.::: ::.::...:..|...|||
Human   566 TFADERGRLKDEIIHKYLYELEHALSSAVLGFQSNQIYGFCSQVPYICSYLLPEEEHTGIYILKP 630

  Fly   518 -----PKQYGFFCVQPPV------GRWALIEIVATEYNTLNFDQFALNEKDELQWIAS-TKSGHF 570
                 .:|||     |.:      |.| ||.|.......:. |.:.|   :...|..| :..||.
Human   631 YKKVQSRQYG-----PGLLYLSSHGLW-LITIAKCGILCIR-DVYTL---ETFAWCRSHSHQGHG 685

  Fly   571 SYILGAGMTKH--LVTWSLGGILVHFKQHKRAKKPFMICRFLNLGMQTEYILRVKECFNSKYLII 633
            ...:...|...  ||.....|.||:.|..:..            |.....||.    :..|.||.
Human   686 IQSMRISMDGQNILVNGRDDGTLVYLKWKRFG------------GHLASEILD----YYQKLLIS 734

  Fly   634 L----------LANKSMRVMRLPSLADFVRENVALPLPTEEGIPCFVEQIIHKVDMFVPLSQR-- 686
            |          |:......:.|.|.::..::..:..|..:       |.::..|...:|..|:
Human   735 LSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQD-------ELVLTDVKKEIPWIQQKS 792

  Fly   687 QEVKEEYTRADLAKREKLFTIIKDFAAKVTALIDYDISKTGKTQGIFK----KFCFHYRWLDALT 747
            ||..::.......||:::...||..:..:..:::    :..|.:.|.|    :|......|:.|.
Human   793 QEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMME----ENDKLENIAKLDQQEFGLDLEELERLH 853

  Fly   748 EEAHKLCALERESLERAIAD---QSRIRDWILRLVTRD---AVSINYRVRSIF-ADANFESFSVR 805
            :|:       :|.:.:.|.|   .:..:.::..|:..:   ::::..|....| .....|:|.::
Human   854 DES-------QEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMK 911

  Fly   806 RKV--EMSEFDKYRFYDLEDHLRLSLGSFEEEEPPAPAAGGHGPPAAIEDGEVDEE------ETV 862
            .:.  |:.|.::                                  .::..:::.|      |.|
Human   912 ARTVEELKELER----------------------------------VLQQKKIEAECLKLRKEIV 942

  Fly   863 EVVQGLRELKPFVVEGPSVYEHIMAPVFQLQDKNLVTSNQLFNY---NCKIRFYLNDPLKQEFNK 924
            |...|::.:|....|.....|.        :||.:..|| |.||   :....|.::..|.....:
Human   943 EAQSGVKLIKQRHEEDDEEEEE--------EDKTVKYSN-LPNYLLGSLSTDFGVDTSLLSSQLE 998

  Fly   925 LFHEAQQLKQDTI--DSVMNTNVVLNKIYD--------------NMNIMLRLLNMDQFKPPELTV 973
            |....:::.|..:  |.:.....|.|..:|              ..|:.:|.:.:|......:..
Human   999 LHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQ 1063

  Fly   974 PSLAKDEVIKQIMEVDDSEVKAINRRKP-----KTIDTGGKKGRLLLWSKEFWARALIVMMDGVL 1033
            |.....|..::.:.|.|.|:.|....||     :.|....|:..||:.......|||:.||.|||
Human  1064 PEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVL 1128

  Fly  1034 EKLWEEEIKKDIPEPEFMQKKQPHEFNLEEQKIFRAYEEAVHLLELDRRKYLRILHENEEKTLAL 1098
            |...|:.::..||:|.||.|... .:..||:|.|:.||:.|..|..:|.||.:.| |.|.|.|..
Human  1129 EVKKEDILRMVIPQPAFMAKPDA-VWTEEERKQFKDYEKKVKELNEERDKYRKSL-EAELKKLQN 1191

  Fly  1099 KASQILK-LNQRVAELMILKLKYDFALKQGQLRM------LTLEKINFGRVQMRKRYNMFRKDID 1156
            ...:..: .::.:..|...::|.:....|.:|::      |.|::    .:..|:::
Human  1192 SIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDE----ELSSREKF-------- 1244

  Fly  1157 KLNDYMTRYSNLLDFYDKAF------LDV-KTRLEAQQTRDRAVERQFRSQFLPLVPHATHEMTK 1214
             ||:|:||..:......:|.      ||| |...:.....|:.::|.|:.:|..:..|....:.|
Human  1245 -LNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYK 1308

  Fly  1215 LFKKRPKLPGKVFNSVLICMEASNKLSGKPSHRTPF-PLP-------DDVLEFLNYLAEFDQPKQ 1271
            |||:||::             :..|...:.:...|| .||       |...:.:..:.|.|....
Human  1309 LFKRRPRI-------------SKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISN 1360

  Fly  1272 CPPNVDPKSWDAFVKLRRQKTESELRLKGIGYQLLDSQALLGVLNKDLAALKESKILTQRNSEDS 1336
            .|..:||..|:.|...||.|.|:|.::|.....||           ::|...:.::..:...:..
Human  1361 MPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLL-----------EMATFLQKRVEEEEKVQQE 1414

  Fly  1337 IQTYL--------EKMR---NMTIQLTLTMGQVEVSVMGQFTKLSNTVLMHVDDINDVNRQIQEA 1390
            |:...        ||:|   |:|||:.|..||||:.......:.|:.:|::.:.|.|:|..|:..
Human  1415 IERVFHELILLQEEKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQ 1479

  Fly  1391 GNKKIKAMQRVAVFRRQVIFKEWEHKLYKANIAYLKYMLDAIEKCKVSMEFLNILRNWE----KV 1451
            |.||:.:|.......::::..|||||                 |.::..|.|| .:.|:    ..
Human  1480 GQKKVASMMESKDVHKRILQIEWEHK-----------------KMEMEREDLN-QKAWDIQMLFF 1526

  Fly  1452 KTERQKYIAG-------AIE-RVIEQKIAVF----RKNIDRVNIKIDAVKAQTLEIKRSNHAIDF 1504
            ..:||||:..       :|: .::||.|||.    :||::.....:..:...:.:...:|:|:..
Human  1527 SRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIANYALSC 1591

  Fly  1505 KIERIKVDVTFQ----NTLRDTMMEDKRDREQRERMSQIKTHRQLMENVRRNYAHVLE-LQTILE 1564
            .:....|.|:.:    |.:...:..:|..:|:.|.|.|    :|.:.|:.:..|..:. |||.:|
Human  1592 NLREELVAVSERKDICNAMGSKLTCEKIVKERYENMMQ----QQKLTNISKQQAEQISILQTEVE 1652

  Fly  1565 LLRLRTYPTL 1574
            .||::|:|.|
Human  1653 RLRMKTFPAL 1662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17687	NP_001368937.1	None
CFAP43	NP_079421.5	WD 1. /evidence=ECO:0000255	108..149		8/40 (20%)
		WD 2. /evidence=ECO:0000255	152..191		8/41 (20%)
		WD 3. /evidence=ECO:0000255	250..290		10/45 (22%)
		WD 4. /evidence=ECO:0000255	299..338		7/38 (18%)
		WD40 repeat	305..342	CDD:293791	7/36 (19%)
		WD 5. /evidence=ECO:0000255	342..381		7/39 (18%)
		WD40 repeat	348..385	CDD:293791	6/37 (16%)
		WD 6. /evidence=ECO:0000255	385..425		9/43 (21%)
		WD40 repeat	390..427	CDD:293791	8/40 (20%)
		WD 7. /evidence=ECO:0000255	427..469		11/54 (20%)
		WD40 repeat	435..470	CDD:293791	9/47 (19%)
		WD 8. /evidence=ECO:0000255	472..511		8/38 (21%)
		WD40 repeat	477..512	CDD:293791	7/34 (21%)
		WD 9. /evidence=ECO:0000255	680..721		10/52 (19%)
		PRK12704	781..>869	CDD:237177	19/98 (19%)
		SMC_N	910..>1655	CDD:481474	184/848 (22%)