Protein Alignment CG17687 and cfap43

DIOPT Version :10

• Sequence 1: NP_001368937.1
• Gene: CG17687 / 39495
• FlyBaseID: FBgn0036348
• Length: 1594
• Species: Drosophila melanogaster
• Sequence 2: XP_697139.4
• Gene: cfap43 / 568701
• ZFINID: ZDB-GENE-080815-3
• Length: 1642
• Species: Danio rerio
• Alignment Length: 1850
• Identity: 366/1850 - (19%)
• Similarity: 679/1850 - (36%)
• Gaps: 496/1850 - (26%)

  Fly     7 VCWCNIWDKDTLVNVGPDVLCQRNGNAMKFVHMQTKAVTFFKAETV-STGLSISCFAGHNRFPLF 70
            |.|...:...|...|....:|...||.:.|::::||     :.:|: |.|..|..|....:....
Zfish    13 VQWVQGFTNGTFRFVDKKTVCYTCGNFIVFLNVETK-----ERKTLQSPGSGIGAFTASGQRRCI 72

  Fly    71 AFAEVVLRPNIYIYRYPDMAKFSSIPPHMMSYTDIRFSELDL------LIAVGGYPDYCLCVFNY 129
            ||:::.|:|:|:||:||::    .:...:...|.:.::.|.|      |::....||:.:.::|:
Zfish    73 AFSDLGLKPSIFIYKYPEL----ELTSELKGTTKLGYTALALCDTGPYLVSASPMPDHIITLWNW 133

  Fly   130 RTGTLVLEQFTNVPTVERGIVISFTSLPSIIQLNKQDMTIICY------EICTVEKESF------ 182
            .:|         :|.....::             .:|::.:.:      :||.::.:|.
Zfish   134 ESG---------LPLCSHSLL-------------DEDISALVFNPMNWCQICAIKSKSLTIWNVE 176

  Fly   183 ------LYKVAEVEL-------------------GK---------------------------KF 195
                  |.|.:.|.|                   ||                           |.
Zfish   177 RCDNYHLMKPSAVNLPGTDGSAIECEPNQSHLLNGKLTYLGPQMPTSAIAGLIGDQADNFVPLKL 241

  Fly   196 LKS--CNRCLSFGEDNTLYATNDFGHLLSVDVACFALKPQWQPTSESDSVTEMEKMPRSHG---- 254
            :|.  |...:.:...:.||.....|.||.|:.....:...::|  :::..|...:||...|
Zfish   242 IKPRLCPSAICWSISSDLYVGCKEGFLLCVNPETLHVSVLYKP--QTEVTTGNSEMPMQEGSFQS 304

  Fly   255 LTYHKSG-FLIWNSTTAYYVKKKAGVFKLE----WEFEGRLNEV-------VRFLSNNNGEIYAE 307
            |....|. |.....:....::.|..  |||    |..|...:.:       ...|::|.|.:|
Zfish   305 LVLQDSKLFAAGMESVLRSIQIKGN--KLEVVQTWALEEAASAMCFSPDGETLLLTSNTGCVY-- 365

  Fly   308 RRPGHIDQVVVDRNGTVSLEAV---VPTGKPVITFRVVQGLKDECVCV-LHDEGVAMM-----DL 363
                ....::.|:...| |:.:   ..|..||.|        |..:|: :.:.||..:     .|
Zfish   366 ----RFKPLLKDKAVKV-LDVLCGDFVTVAPVYT--------DRSICLSVREAGVVQLWTLDDGL 417

  Fly   364 AKGNTLCEVSVPGATAMCNHRSLALVVVGTLDASIVLIHFERASLPHVLCDLKMETAAVVGIEFN 428
            ..|:...:..|   |:|........:||||....::.:.......|.::..:.:....|..:.|:
Zfish   418 CMGSISLQTHV---TSMACCPIAQYIVVGTATGDVLFVEMTTKQKPRLVHRVHLYHVPVDHLVFD 479

  Fly   429 DSWVVFQDQMKVLHVVQVDNRPHK-----------------LTHYFEMNPPELSQVFIHTFLLAD 476
            ..............|..:|:||.|                 .|.|.:    |..|:
Zfish   480 QGGNCLITGASDSRVFVLDSRPSKGFDIIGWIEAPGAIVGLSTQYHQ----ESKQI--------- 531

  Fly   477 GPRLMVFINRDHSMKRPG--------FATELWLYNWGKDKRLH---RREYI------LP------ 518
              :::|..|:.......|        ||.:|.......|  .|   |:|..      ||
Zfish   532 --KVLVLCNKSEKEISEGNVLLLLTLFAQQLTESTSCMD--AHGCLRKEVFDSCVLELPNSLCSC 592

  Fly   519 -----KQYGFFCVQPPVGRWALIEIVATEYNTLNFDQFALNEKDE-----LQWIASTKSGHFSYI 573
                 |.:| :|.|..|                 ..:|::.|..|     :|.|...::|  .::
Zfish   593 VLAVNKIFG-YCQQRKV-----------------LQRFSIPENGENPNNVVQLIPEKETG--GHL 637

  Fly   574 LGAG---MTKHLVTW--SLG--GILVHFKQHKRAKKPFMICRFLNLGMQTEYI-LRVKECF---- 626
            |...   ::.| .||  |:|  |:|                |...:.....|: |:...|:
Zfish   638 LSPAFLQLSPH-HTWLASVGRDGLL----------------RICEISEMDRYVQLQCHSCWQGGV 685

  Fly   627 -------NSKYLIIL-LANKSMRVMRLPSLADFVRENVALPLPTEEGIPCFVEQIIHKVDMFVPL 683
                   :|:.:|.. |.:.|:...|| .|:...:.|.|                         .
Zfish   686 GSVCFTPDSQTIITSGLRDGSLVCSRL-KLSGVGKANAA-------------------------T 724

  Fly   684 SQRQEVKEEYTRADLAKREKLFTIIKDFAAKVTALIDYDISKTGKTQGIFKKFCFH--------- 739
            ...|.|.:.:.           :::......:|.:.|.|...||:..  .|....|
Zfish   725 QYSQSVADSFE-----------SVVSSENTVLTKMTDRDSFHTGEVS--LKGKMSHEAEQEENYF 776

  Fly   740 -----YRWLD-----ALTEEAHKLCALERESLERAIADQSRIRDWILRLVTRDAVSINYRVRSIF 794
                 |.|||     .|.|||.:. |..:::|.|.|.            |.||.:..........
Zfish   777 TSPTSYTWLDGKLDAVLQEEAQQY-AETKKNLRRNIK------------VLRDTIKAMMEENESL 828

  Fly   795 ADANFESFSVRRKVEMSEFDKYRFYDLEDHLRLSLGSFEE------------------------E 835
            ||.        .|:|..||:    .|:|:..||.|...:|                        |
Zfish   829 ADI--------EKLEQQEFN----LDVEEQQRLQLEGDQEVNRVRKEIEMENLAKSYQREVLKRE 881

  Fly   836 EPPAPAAGGHGPPAAIEDGEV----------DEEETVEVVQGLRELKPFVVEGPSVYEHIMAPVF 890
            ...:....|....|...:.||          .|.|.:.:|:.:|:::.   |...:.|.::..:|
Zfish   882 CWDSMQVKGKAIKAFHSENEVKNYPMKERTAKELEELRMVENMRQIEQ---EDSQLQEGVLDTLF 943

  Fly   891 --QLQDKNLVTSNQLFNYNCKIRFYLNDPLKQEFNKLFHEAQQLKQDTI--DSVMNTNVVLNKIY 951
              :.::.:|..|..|......:...:|..|..:|| |....|::.|.|:  |.:.|.....||.:
Zfish   944 GDKEEEVSLTESPALTGSLSSLYGGVNPYLYNQFN-LHVREQKINQITLLKDVIYNVKSAFNKEF 1007

  Fly   952 DNM-------------------NIMLRLLNMDQFKPPELTVPSLAKDEVIKQIMEVDDSEVKAIN 997
            :.:                   .||.:|...:....|.||     .:|..::.:.|.|||:|.
Zfish  1008 EAVYKQKEQEIHRTKEKNKRIFQIMAKLGISETLWEPRLT-----DNECPERALTVTDSEIKV-- 1065

  Fly   998 RRKPKTIDTGGKKG---------RLLLWSKEFWARALIVMMDGVLEKLWEEEIKKDIPEPEFMQK 1053
             .|..|::...|:.         ||...|:....:.|.|||.||||...|:.::.::|:||||.|
Zfish  1066 -EKYLTLEQKEKEAKLREEEERQRLAAKSENMRDQGLSVMMGGVLELKKEDVLRMEVPQPEFMSK 1129

  Fly  1054 KQPHEFNLEEQKIFRAYEEAVHLLELDRRKYLRILHENEEKTLALKASQILKL-NQRVAELMILK 1117
            .:. ::..||:|.|:.:|:....|..::.||.:.| |.|.|.|.....:..:: ::::|:|...|
Zfish  1130 PEA-QWTEEERKSFKEFEKKAKELSEEQEKYRKTL-ETEMKKLLTSIKEATQMFDEKLAKLFERK 1192

  Fly  1118 LKYDFALKQGQLRMLTL-------EKINFGRVQMRKRYNMFRKDIDKLNDYMTRYSNLLDFYDKA 1175
            :|.:..:.|.:|::..|       |:|.....|:..:....|...:::.:.:.::...:|.:.:|
Zfish  1193 VKSEMVIYQEELKIANLVLSIQTEEEILTREKQLSFKLEKARIKKNEIGEELKKHKETVDEFREA 1257

  Fly  1176 FLDVKTRLEAQQTRDRAVERQFRSQFLPLVPHATHEMTKLFKKRPKLPGKVFNSVLICMEASNKL 1240
            :       :.....|:.:::.||.:|..:..|:..::.||:|:||::                :.
Zfish  1258 Y-------DNTVAEDKLLDKGFRKEFYDVPGHSIDQLYKLYKRRPRV----------------QR 1299

  Fly  1241 SGKPSHRTPF---PLPDDVLE-FLNYLAEFDQPKQCPPNVDPKSWDAFVKLRRQKTESELRLKGI 1301
            ....:...||   ..|.|.|. .:..:.|.|.|:.....:||..|:.|...||.|.|||.::|..
Zfish  1300 MKTQTENNPFKEGAAPSDGLSLMMKAMEELDAPEHMLEGLDPAVWERFCLARRAKVESEQKVKLK 1364

  Fly  1302 GYQLLDSQALL--GVLNKDLAALKESKILTQRNS--EDSIQTYLEKMRNMTIQLTLTMGQVEVSV 1362
            ...|.:.||.|  .:...|.|.|:...::.:.|.  ::.::..|:.|    :|:.|..|||||..
Zfish  1365 ALTLAEMQAFLQRRIDEDDEAQLEIKNLIDELNGLCDEKMRFRLDSM----VQIVLQQGQVEVEA 1425

  Fly  1363 MGQF-TKLSNTVLMHVDDINDVNRQIQEAGNKKIKAMQRVAVFRRQVIFKEWEHKLYKANIAYLK 1426
             |:| ...||.:|:....:.|:|..|:..|::||..|.....||:.:|.:||||:..:..:..|.
Zfish  1426 -GEFIADYSNALLIQRKVVEDLNSTIRALGDQKIATMVECKDFRKGIIQQEWEHRRMRMQLEDLS 1489

  Fly  1427 YMLDAIEKCKVS---MEFLNILRNWEKVKTERQKYIAGAIERVIEQKIAVFRKNIDRVNIKIDAV 1488
            .....|:..:::   .::||...|..:|..:     ...:||.::.:....:|.|:....:...:
Zfish  1490 NKARNIQTLRITQDIQDYLNETNNDNRVSKQ-----LTTLERTLDLQKTAHQKKIEICKKQKRQL 1549

  Fly  1489 KAQTLEIKRSNHAIDFKIERIKVDVT-FQNTLRDTMMEDKRDREQRERMSQIKTHRQLMENVRRN 1552
            ..|..:::..|.|:|.::..:::.|. .:|......|||.::.|..:....|...::|:...|..
Zfish  1550 DRQVAKMQEKNAALDLRVAEMEITVAERRNFYEAAAMEDNQETESDKNYQDILLRKKLLAIARAQ 1614

  Fly  1553 YAHVLELQTILELLRLRTYPTLGPPLPQCH 1582
            ...:|.|:..||.||::.:|:|.    |.|
Zfish  1615 SEELLLLRAELEKLRMKNFPSLS----QLH 1640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17687	NP_001368937.1	None
cfap43	XP_697139.4	WD40	93..443	CDD:475233	63/393 (16%)
		WD40 repeat	343..389	CDD:293791	7/52 (13%)
		WD40	<344..498	CDD:441893	28/171 (16%)
		WD40 repeat	428..465	CDD:293791	8/39 (21%)
		WD40 repeat	473..512	CDD:293791	7/38 (18%)
		WD40	635..>707	CDD:475233	15/88 (17%)
		WD40 repeat	642..680	CDD:293791	10/54 (19%)
		CCDC158	793..>1571	CDD:464943	188/849 (22%)