Protein Alignment CG17687 and Cfap43

DIOPT Version :10

• Sequence 1: NP_001368937.1
• Gene: CG17687 / 39495
• FlyBaseID: FBgn0036348
• Length: 1594
• Species: Drosophila melanogaster
• Sequence 2: NP_001419285.1
• Gene: Cfap43 / 365476
• RGDID: 1560545
• Length: 1674
• Species: Rattus norvegicus
• Alignment Length: 1826
• Identity: 368/1826 - (20%)
• Similarity: 684/1826 - (37%)
• Gaps: 435/1826 - (23%)

  Fly     6 TVCWCNIWDKDTLVNVGPDVLCQRNGNAMKFVHMQTKAVTFFKAETVSTGLSISCFAGHNRFPLF 70
            :|.|...:....:..|..:.:|..:||.:.|::::||..|..:......|:..:...|.    :.
  Rat    28 SVRWVQGFPSQNVHFVNDNTICYPSGNYVIFINLETKKKTVLQCINGIVGVMATNVPGE----VV 88

  Fly    71 AFAEVVLRPNIYIYRYPDMAKFSSIPPH-MMSYTDIRFSELDLLIA-VGGYPDYCLCVFNYRTGT 133
            ||::..|:|.||||.:|.:.:...:... ::.|..:.||.....:| ....|::.|.::|:....
  Rat    89 AFSDRRLKPIIYIYSFPSLTRKIKLKGDILLDYNLLCFSYCGTYLASYSSLPEFELALWNWEANV 153

  Fly   134 LV---------LEQFTNVPTVERGIVISFTSLPSIIQLNKQDMTIICYEICTVEKESFLYKVAEV 189
            ::         :.|.|..|...|.:.:|..|..|:..:.:.:           ::..|..::.::
  Rat   154 ILCKKSNPGMDVSQMTFNPMNWRQMCLSSPSAVSVWTIERSN-----------QEHHFRIRLVKL 207

  Fly   190 ---------ELGKKFLKSCNRCLSFG--------------EDNTLYATNDFGHLLSVDVACFALK 231
                     |....|..|..:.|.:|              |..|....:|...||...:.|
  Rat   208 PQEDGTLSNETDMLFPTSLPKDLIYGPVLPLSAIAGLVGEEAETFRPKDDIYPLLHPTMHC---- 268

  Fly   232 PQWQPTS----------------ESDSVT---EMEKMPRSHG--------LTYHKSGFL---IWN 266
              |.|:|                |:..||   ::|:.|...|        |.|.|.|.|   |..
  Rat   269 --WTPSSDLYVGCEEGHLLMINTETLKVTVLQKLEEFPVLDGAQLINPLTLVYQKDGILASGIDG 331

  Fly   267 STTAYYVKKKAGVFKLEWEFEGRLNEV-------VRFLSNNNGEIYA---ERRPGHIDQVVVDRN 321
            ...::.:|......|...||:|.:..:       :..:..:.|.:|.   ...| .:|:::...:
  Rat   332 VIYSFIIKDTKYEVKPFLEFDGPVAHLAFSPSYKMLLIQTDKGSVYIYTFGTEP-VLDKLLEACD 395

  Fly   322 GTV-SLEAVVPTGKPVITFRVVQGLKDECVCVLHDEG-VAMMDLAKGNTLCEVSV-PGATAMCNH 383
            |.| ::..:.|..|..:|              |...| |::..:..|.....:.: ..||.:...
  Rat   396 GKVQAISFITPGNKYFLT--------------LTSSGEVSIFSIEDGTCTGRIFLRTHATTLACS 446

  Fly   384 RSLALVVVGTLDASIVLIHFERASLPHVLCDLKMETAAV-------------VGIEFNDSWVV-- 433
            .|.:...:||:|.|:..::......|.::....:..:.|             ||.|....:|:
  Rat   447 PSSSSAAMGTVDGSVYFLNILDVESPQLIHQAFLSKSPVKILIYDQRGIFLLVGTEEGKIFVIDA 511

  Fly   434 -----FQ----------------------DQMKVLHVVQVDNRPHKLTHYFEMNPPELSQVFIHT 471
                 ||                      |.::||.:..:.........||.: |..|.||....
  Rat   512 RPSKSFQIFGYTESSKDMLQISTVSHVESDVVEVLVLSPLSETGRSRLEYFTL-PIMLPQVVPEN 575

  Fly   472 FLLADGPRLMVFINR-----DHSM----------KRPGFATEL-WLYNWGKDKRLHR-------R 513
            |....|.....|.:|     :|::          |..||.::: ::.::....:.|.       :
  Rat   576 FADERGRLKDNFTHRYLYEVEHALSSAVLGFSESKIYGFCSQVPYICSYTMPVKEHTGICILKPQ 640

  Fly   514 EYILPKQYGFFCVQ-PPVGRWALIEIVATEYNTLNFDQFALNEKDELQWIASTKSGHFSYILGAG 577
            :.:..||||...:. ...|.| ||.|.......:. |.|:|:     .::......|.    |.|
  Rat   641 QKVQSKQYGAGTIYLSSHGLW-LITIAKCGVLCIR-DMFSLD-----TFVRCRSHSHH----GQG 694

  Fly   578 MTKHLVTWSLGGILVHFK--------QHKR-----AKKPFMICRFLNLGM------QTEYILRVK 623
            :....::.....|||:.|        :.||     |.:.|..|..|.|.:      :.:|:.
  Rat   695 IQNMKMSMDGQHILVNGKDDNTLVYLKWKRLGSNIANEIFEHCHQLMLSLAKTVETECDYLA--- 756

  Fly   624 ECFNSKYLIILLANKSMRVMRLPSLADFVRENVALPLPTEEGIPCFVEQIIHK-VDMFVPLSQRQ 687
               :..|..:....::....:..||.. .:|.:|:.|.....|...:|:.:.| |.:|.|  :|:
  Rat   757 ---SPDYQCVPPEEETTEFQKKLSLYS-SQEELAIDLNKIPWIQRKMEEAVKKEVRIFTP--RRK 815

  Fly   688 EVKE------EYTRADLAKREKLFTIIKDFAAKVTALIDYDISKTGKTQGIFKKFCFHYRWLDAL 746
            |:|.      :...|.:.:.|||.||.|         :|.            ::||.....|:.|
  Rat   816 EIKRGIKELAQIIAAMMEENEKLDTIAK---------LDE------------QEFCLDAEELERL 859

  Fly   747 TEEAHKLCALERESLERAIADQSRIRDWILRLVTRD---AVSINYRVRSIF-ADANFESFSVRRK 807
            .:|    |..|...:.:.:...:..:.::..|:..:   ::::..|....| .....::|.::.:
  Rat   860 HDE----CEEEVSKIRKDVEMHNLAKSYLTELIKEECWNSMAVKGRALKCFHIPYVVDNFPMKER 920

  Fly   808 -----VEMSEFDKYRFYDLEDHLRLSLGSFEEEEPPAPAAGGHGPPAAIEDGEVDEEETVEVVQG 867
                 :|:|:..:.:..::| .|:|.....|.:.........|      |:.|.:|||..|.
  Rat   921 TEEELLELSKVIQQKKTEIE-CLKLRKEIVEAQSAATMVKKHH------EEEEEEEEEDEEK--- 975

  Fly   868 LRELKPFVVEGPSVYEHIMAPV---FQLQDKNLVTSNQLFNYNCKIR--FYLND---PLKQEFNK 924
                   ||:..|:..:::..:   |......|....:|.:...||.  ..|.|   .:|:.||.
  Rat   976 -------VVKSTSLPNYLLGSLSTDFGADTSLLTNQLELHSREEKINQIILLKDIIYNIKKTFNS 1033

  Fly   925 LFHEAQQLKQDTIDSVMNTNVVLNKIYDNMNIMLRLLNMDQFKPPELTVPSLAKDEVIKQIMEVD 989
            .|..|.:.|:..|..|...||.:.:|..::.:           ..::..|.....|..::.:.|:
  Rat  1034 EFDAAYKQKEIEIARVQEKNVRIAEIISDLEL-----------EEKVWQPVFEDSEKPERALVVE 1087

  Fly   990 DSEVKAINRRKP--KTIDTGGKKGRLLLWSKEFWA-------------RALIVMMDGVLEKLWEE 1039
            |.|:.......|  ||      |..||   ..|.|             |.|:.||.||||...|:
  Rat  1088 DDEISLQKYFAPWHKT------KAELL---TAFDAERLQQARLSDARHRGLMDMMGGVLEVKKED 1143

  Fly  1040 EIKKDIPEPEFMQKKQPHEFNLEEQKIFRAYEEAVHLLELDRRKYLRILHENEEKTLALKASQIL 1104
            .::..||:|.||.|... .::.||:|.|:.||:.|..|..:|.||.:.|....:|..........
  Rat  1144 ILRMVIPQPPFMSKPDA-LWSEEERKQFKEYEKKVKELNEERDKYRKSLEAELKKLQNAIQENTQ 1207

  Fly  1105 KLNQRVAELMILKLKYDFALKQGQLRM------LTLEKINFGRVQMRKRYNMFRKDIDKLNDYMT 1163
            ..::.:..|...::|.:..:.|.:|::      |.|::....|.|....|      :.|..|..|
  Rat  1208 NFDEHLKRLFERRVKAEMVINQEELKINNIVFSLLLDEELSSREQFLNNY------LQKKQDEKT 1266

  Fly  1164 RYSNLLDFYDKAFLDVKTRLEAQQT---RDRAVERQFRSQFLPLVPHATHEMTKLFKKRPKLPGK 1225
            :.|..:   .||..|:....|...|   .|:.::|.|:.:|..:..|....:.||||:||::|.:
  Rat  1267 KTSEAI---QKAREDLDVFKENHDTLVAEDKVLDRSFKKEFSDISGHQVDVLYKLFKRRPRVPKQ 1328

  Fly  1226 ----VFNSVLICMEASNKLSGKPSHRTPFPLPDDVLEFLNYLAEFDQPKQCPPNVDPKSWDAFVK 1286
                ..|:::...|...  |||.:..|       ..:.:..:.|.|.....|..:||..|:.|..
  Rat  1329 KTQTEVNTLVPYGERPG--SGKLNKET-------FAQLMKSMDELDNVSNMPEGLDPSVWEHFCA 1384

  Fly  1287 LRRQKTESELRLKGIGYQLLDSQALLGVLNKDLAALKESKILTQRNSEDSI------QTYLEKMR 1345
            .||.|.|:|.::|                .|....|:.:..|.:|..:|.:      :.:.|.:|
  Rat  1385 TRRAKVENEYKVK----------------QKAACLLEMTTFLRKRMEDDDVVHHEIERVFHELVR 1433

  Fly  1346 ----------NMTIQLTLTMGQVEVSVMGQFTKLSNTVLMHVDDINDVNRQIQEAGNKKIKAMQR 1400
                      |:|:|:.|..||||:.......:.|:.:|::.:.|.::|..|:..|.||:.:|..
  Rat  1434 LQDEKVKFQVNLTVQILLKQGQVELENFQLTLEYSDAILINKNIIEELNSVIRTQGQKKVASMME 1498

  Fly  1401 VAVFRRQVIFKEWEHKLYKANIAYLKYMLDAIEKCKVSMEFLNILRNWE----KVKTERQKYI-- 1459
            .....:.:...|||||                 |.::.||.|| .:.|:    ....:||||:
  Rat  1499 SKEVHKGIYQIEWEHK-----------------KMEMEMEDLN-QKAWDIQMLFFSRDRQKYLNE 1545

  Fly  1460 ---AGAIE---RVIEQKIAVFRKNIDRVNI--------KIDAVKAQTLEIKRSNHAIDFKIERIK 1510
               .|.|.   .::||.|:|..|| .:.|:        |:.....|. ::...|.:.:.:.|.:.
  Rat  1546 PNYEGVIAIQIGIMEQTISVIDKN-HKKNVENCKKLLKKLGKCSNQK-DVANYNLSCNLREELVA 1608

  Fly  1511 V----DVTFQNTLRDTMMEDKRDREQRERMSQIKTHRQLMENVRRNYAHVLE-LQTILELLRLRT 1570
            |    |:.  |.:...:..:|..||:.:.:.:    :|.:.|:.:..|..:. ||..:|.||::|
  Rat  1609 VSERQDIC--NEIGSKLTCEKIARERYDNLMK----QQKLTNISKQQAEQISILQAEVERLRMKT 1667

  Fly  1571 YPTLGP 1576
            :|.|.|
  Rat  1668 FPALVP 1673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17687	NP_001368937.1	None
Cfap43	NP_001419285.1	WD40 repeat	313..351	CDD:293791	8/37 (22%)
		WD40	<324..506	CDD:475233	32/196 (16%)
		WD40 repeat	358..395	CDD:293791	4/37 (11%)
		WD40 repeat	399..438	CDD:293791	7/52 (13%)
		WD40 repeat	443..480	CDD:293791	6/36 (17%)
		WD40 repeat	488..521	CDD:293791	6/32 (19%)
		PRK03918	<766..>905	CDD:235175	31/166 (19%)
		PTZ00121	<1037..1370	CDD:173412	86/371 (23%)