Protein Alignment CG17687 and Cfap43

DIOPT Version :10

• Sequence 1: NP_001368937.1
• Gene: CG17687 / 39495
• FlyBaseID: FBgn0036348
• Length: 1594
• Species: Drosophila melanogaster
• Sequence 2: NP_081835.2
• Gene: Cfap43 / 100048534
• MGIID: 1289258
• Length: 1682
• Species: Mus musculus
• Alignment Length: 1854
• Identity: 371/1854 - (20%)
• Similarity: 682/1854 - (36%)
• Gaps: 491/1854 - (26%)

  Fly     6 TVCWCNIWDKDTLVNVGPDVLCQRNGNAMKFVHMQTKAVTFFKAETVSTGLSISCFAGHNRFPLF 70
            :|.|...:....:..|....:|..:||.:.|::::||..|..:......|:    .|.:....:.
Mouse    36 SVRWVQGFPSQNVHFVNDQTICYPSGNFVIFINLETKKKTVLQCINGIVGV----MATNVPSEVV 96

  Fly    71 AFAEVVLRPNIYIYRYPDMAKFSSIPPH-MMSYTDIRFSELDLLIA-VGGYPDYCLCVFNYRTGT 133
            ||::...:|.||||.:|.:.:.:.:... ::.||.:.||.....:| ....|::.|.::|:....
Mouse    97 AFSDRRFKPVIYIYSFPSLTRKNKLKGDILLDYTLLCFSYCGTYLASYSSLPEFELALWNWEASA 161

  Fly   134 LVLEQFT--------------------------NVPTVERG-----IVISFTSLP--SIIQLNKQ 165
            ::.::..                          :|.|:||.     ..|....||  ....||:.
Mouse   162 ILCKKSNPGMDVSQMSFNPMNWHQMCLSSSSAMSVWTIERSNQEHHFRIRSVKLPLEDATFLNEP 226

  Fly   166 DMT----------------------IICYEICTVEKESFLYKVAEVELGKKFLKSCNRCLSFGED 208
            ||.                      ::..|..|...:..:|.:         |.....|.:...|
Mouse   227 DMLFPTTLPKDLIYGPVLPLSAIAGLVGEEAETFRPKDDIYPL---------LHPTMHCWTPSSD 282

  Fly   209 NTLYATNDFGHLLSVDVACFALKPQWQPTSESDSVTEMEK---MPRSHG--------LTYHKSGF 262
              ||...:.||||.::             :|:..||.::|   .|...|        |.|.|.|.
Mouse   283 --LYVGCEEGHLLMIN-------------TETLKVTVLQKAEEFPLPDGAPLINPLTLVYQKDGI 332

  Fly   263 L---IWNSTTAYYVKKKAGVFKLEWEFEGRLNEVV-------RFLSNNNGEIY-----AERRPGH 312
            |   |.....::.:|......|...||:|.:..:|       ..:..:.|.:|     ||.   .
Mouse   333 LASGIDGVIYSFIIKDSKYQVKTFLEFDGPVTHLVFSPSYKMLLIQTDKGSVYIYTFGAEM---P 394

  Fly   313 IDQVVVDRNGTV-SLEAVVPTGKPVITF----RVVQGLKDECVCV----LHDEGVAMMDLAKGNT 368
            :|:::...:|.| ::..:.|..|..:|.    .|.....::|.|.    |..:..|:
Mouse   395 LDKLLDACDGKVQAVSFITPGTKYFLTLTSSGEVSTVSLEDCNCTSRIFLKTQATAL-------- 451

  Fly   369 LCEVSVPGATAMCNHRSLALVVVGTLDASIVLIHFERASLPHVLCDLKMETAAV----------- 422
            .|..|.|.|            .|||:|..:..::......|.::....:..:.|
Mouse   452 ACSPSSPTA------------AVGTVDGYVYFLNILDVESPQMIHQAFLSQSPVKIVTYDQRGIF 504

  Fly   423 --VGIEFNDSWVV-------FQ----------------------DQMKVLHVVQVDNRPHKLTHY 456
              ||.|..:.:|:       ||                      |.::||.:..:.:.......|
Mouse   505 LLVGTEEGNIFVIDARPSKSFQIFGFTETGKDILQISTVSVMESDVVEVLVLYPLPDMGRSRLEY 569

  Fly   457 FEMNPPELSQVFIHTF-----LLADGPRLMVFINRDHSM----------KRPGFATEL-WLYNWG 505
            |.: |..|.:|....|     .|.|..........:|::          |..||.::: ::.::.
Mouse   570 FTL-PVMLPEVVPENFSDERGRLKDDLTHKYLYEVEHTLSSAVLGFTGSKIFGFCSQVPYICSYV 633

  Fly   506 KDKRLHRREYIL-------PKQYGFFCVQ-PPVGRWALIEIVATEYNTLNFDQFALNEKDELQWI 562
            ...:.|....:|       .||||...:. ...|.| |:.|.......:. |.|::.     .::
Mouse   634 MPVKEHTGVLVLKPHQKVQSKQYGSGTIYLSSHGLW-LMTIAKCGILCIR-DMFSME-----TFV 691

  Fly   563 ASTKSGHFSYILGAGMTKHLVTWSLGG--ILVHFKQHKRAKKPFMIC-RFLNLGM---------Q 615
            ......|    .|.|:..  :..||.|  |||:.|....     ::| ::..||.         .
Mouse   692 RCRSHSH----QGRGIQN--MKMSLDGQHILVNGKDDNT-----LVCLKWKRLGANIASEIFEHS 745

  Fly   616 TEYILRVKECFNSKYLIILLANKSMRVMRLPSLADFVRENVALPLPTEEGIPCFVEQIIHKVDMF 680
            ...:|.:.:...|:.:.:.|:.:|....:..:...  ::::......||.:      |.||:..:
Mouse   746 RPLVLHLSQTVESESVYLALSRESTNEQQEETTES--QKHLNSDSSEEEAV------IDHKMIPW 802

  Fly   681 VPLSQRQEVKEEYTRADLAKREKLFTIIKDFAAKVTALIDYD-----ISKTGKTQGIFKKFCFHY 740
            :.....:.:|:| .|....:|:::...||:.|..:..:::.:     |:|..:     ::||...
Mouse   803 IQQKMEEAIKKE-VRIFSPRRKEIKRGIKELAQVIAMMMEENEKVDIIAKLDE-----QEFCLDA 861

  Fly   741 RWLDALTEEAHKLCALERESLERAIADQSRIRDWILRLVTRDAVSINYRVRSIF-----ADANFE 800
            ..|:.|.:|..:..|..|:.:|.....||.:.: :::....:::::..|....|     .| ||
Mouse   862 DELERLHDECEEEVAKIRKDVEMHNLAQSYLTE-LIKEECWNSMAVKGRALKCFHIPYVVD-NF- 923

  Fly   801 SFSVRRKVEMSEFDKY---------------RFYDLEDHLRLSLGSFEEEEPPAPAAGGHGPPAA 850
            ....|.:.|:.|..|.               ...:::....::....|||
Mouse   924 PMKERTEEELQELSKVMQQKKTEIECLKLRKEIVEVQATTTIAKKHHEEE--------------- 973

  Fly   851 IEDGEVDEEETVEVVQGLRELKPFVVEGPSVYEHIMAPVFQL--------QDKNLVTSN-QLFNY 906
             |:.|.|||.|::...                    .|.:.|        .|.:|:||. .|.:.
Mouse   974 -EEEEEDEERTIKTTS--------------------LPNYLLGSLSTDFGADTSLLTSQLDLHSR 1017

  Fly   907 NCKIR--FYLND---PLKQEFNKLFHEAQQLKQDTIDSVMNTNVVLNKIYDNMNIMLRLLNMDQF 966
            ..||.  ..|.|   .:|:.||..|..|.:.|:..|..|...||.:.:|..::.:
Mouse  1018 EEKINQIILLKDIIYNIKRNFNSEFDAAYKQKEIEIARVKEKNVRIAEIISDLEL---------- 1072

  Fly   967 KPPELTV--PSLAKDEVIKQIMEVDDSEV---KAI---NRRKPKTIDTGGKKGRL--LLWSKEFW 1021
               |.||  |.....|..::.:.|:|.|:   |.|   .|.|.|.:.:..:..||  ...|.| .
Mouse  1073 ---EETVWQPVFEDSEKPERALVVEDDEISFKKYIAPWQRAKIKEVVSTYEMERLQQARISDE-R 1133

  Fly  1022 ARALIVMMDGVLEKLWEEEIKKDIPEPEFMQKKQPHEFNLEEQKIFRAYEEAVHLLELDRRKYLR 1086
            .|.|:.||.||||...|:.::..||:|.||.|... .::.:|:|.|:.||:.|..|..:|.||.:
Mouse  1134 QRGLMDMMGGVLEVKKEDILRMVIPQPPFMAKADA-LWSEDERKQFKEYEKKVKELNEERDKYRK 1197

  Fly  1087 ILHENEEKTLALKASQILKLNQRVAELMILKLKYDFALKQGQLRM------LTLEKINFGRVQMR 1145
            .|....:|............:..:..|...::|.:..:.|.:|::      |.|::....|.|..
Mouse  1198 SLEAELKKLQNSIQESTQNFDDHLKRLFERRVKAEMVINQEELKINNIIFSLLLDEELSSREQFL 1262

  Fly  1146 KRYNMFRKDIDKLNDYMTRYSNLLDFYDKA--FLDV-KTRLEAQQTRDRAVERQFRSQFLPLVPH 1207
            ..| :.:|..:|        :...:...||  .||| |...:.....|:.::|.|:.:|..::.|
Mouse  1263 NNY-LLKKQEEK--------TKTAEAIQKAREDLDVFKEHHDMLVAEDKILDRSFKKEFSDILGH 1318

  Fly  1208 ATHEMTKLFKKRPKL------------------PGKVFNSVLICMEASNKLSGKPSHRTPFPLPD 1254
            ....:.||||:||::                  ||            |.||:           .:
Mouse  1319 QVDVLYKLFKRRPRVHKQKTQADVTSLVPYGERPG------------SAKLN-----------KE 1360

  Fly  1255 DVLEFLNYLAEFDQPKQCPPNVDPKSWDAFVKLRRQKTESELRLKGIGYQLLDSQALLGVLNKDL 1319
            ::.:.:..:.|.|.....|..:||..|:.|...||.|.|:|.::|                .|..
Mouse  1361 NLAQLMKSMDELDNINNMPEGLDPSVWEHFCSTRRAKVENEYKVK----------------QKAA 1409

  Fly  1320 AALKESKILTQRNSEDS-------------IQTYLEKMR---NMTIQLTLTMGQVEVSVMGQFTK 1368
            ..|:.:..|.:|..||.             |:...||:|   |:|:|:.|..||||:.......:
Mouse  1410 CLLEMTTFLRKRMEEDDVVHHEIEKVFHELIRLQDEKVRFQVNLTVQILLKQGQVELENFQLMLE 1474

  Fly  1369 LSNTVLMHVDDINDVNRQIQEAGNKKIKAMQRVAVFRRQVIFKEWEHKLYKANIAYLKYMLDAIE 1433
            .|:.:|::.:.|.|:|..|:..|.||:.:|.......:.:...|||||
Mouse  1475 YSDAILINKNIIEDLNSVIRTQGQKKVASMMESKEVHKGIYQIEWEHK----------------- 1522

  Fly  1434 KCKVSMEFLNILRNWE----KVKTERQKYI-------AGAIE-RVIEQKIAVF----RKNIDRVN 1482
            |.::.||.|| .|.|:    ....:||||:       ..||: .::||.|:|.    :||::...
Mouse  1523 KMEMEMEDLN-QRAWDIEMLFFSRDRQKYLNEPNYENVIAIQIGIMEQTISVIDKTHKKNVENCK 1586

  Fly  1483 IKIDAVKAQTLEIKRSNHAIDFKIERIKVDVTFQ----NTLRDTMMEDKRDREQRERMSQIKTHR 1543
            ..:..:...:.:...:|:.:...:....|.|:.:    |.:...:..:|..||:.:  :|:|  :
Mouse  1587 KLLKKLGKYSNQKDVANYTLSCNLREELVAVSERQDICNEIGSKLTCEKIARERYD--NQLK--Q 1647

  Fly  1544 QLMENVRRNYAHVLE-LQTILELLRLRTYPTLGP 1576
            |.:.|:.:..|..:. ||..:|.||::|:|.|.|
Mouse  1648 QKLLNISKQQAEQISILQAEVERLRMKTFPALIP 1681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17687	NP_001368937.1	None
Cfap43	NP_081835.2	WD 1. /evidence=ECO:0000255	168..207		4/38 (11%)
		WD 2. /evidence=ECO:0000255	262..305		13/66 (20%)
		WD 3. /evidence=ECO:0000255	315..354		8/38 (21%)
		WD40 repeat	321..358	CDD:293791	8/36 (22%)
		WD40	<332..514	CDD:475233	36/204 (18%)
		WD 4. /evidence=ECO:0000255	358..397		8/41 (20%)
		WD40 repeat	363..390	CDD:293791	3/26 (12%)
		WD40 repeat	407..443	CDD:293791	6/35 (17%)
		WD40 repeat	448..485	CDD:293791	10/56 (18%)
		WD 5. /evidence=ECO:0000255	488..527		6/38 (16%)
		WD40 repeat	493..533	CDD:293791	7/39 (18%)
		WD 6. /evidence=ECO:0000255	697..738		13/51 (25%)
		PRK03918	<757..1233	CDD:235175	113/543 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	767..790		1/24 (4%)
		PTZ00121	<1108..1539	CDD:173412	120/498 (24%)