DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and lrrn3

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001072526.1	Gene:	lrrn3 / 779981	XenbaseID:	XB-GENE-490955	Length:	706	Species:	Xenopus tropicalis

Alignment Length:	393	Identity:	105/393 - (26%)
Similarity:	175/393 - (44%)	Gaps:	49/393 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LGLA------------NCPNGCECD-----------DDTLMVNCGEGTLDVLPIALNPAIQRLVI 79
            ||||            :||:.|.|:           .:.|.|:|....|..:|..|....|.|::
Frog    12 LGLAIATHGHTTPKKMDCPHSCSCEIRPWFTPKSIYIEALTVDCNALDLYSVPDKLPAKTQILLL 76

  Fly    80 KNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLST 144
            :.|.::.|.::..|...||.||||.|::..|...:|....::..::|:.||:.::...:|.||.
Frog    77 QANNIEEIKNTDHFPVNLTGLDLSQNNLSLIANINFTNMHQILSVYLEENKLTELMEGSFSGLE- 140

  Fly   145 ISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGE 209
                                   .|.||.:..|.||.|.|.|..|:.||..|:|:.|.|..: ..
Frog   141 -----------------------NLQELYINHNLISVISPKAFAGVSNLLRLHLNSNRLQMI-NS 181

  Fly   210 LTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLSDN 274
            :.|:|:.:|..|.:|.|..:.|....|:.|..|..|.|.|..|..|..:|..||..|..:...||
Frog   182 MWFEAIPNLEILMIGENPIVNIEDMNFKPLINLRSLVLAGVNLTEIPDNAFLGLDKLESISFYDN 246

  Fly   275 RLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNL 339
            :...:|:.|.|::..|:.|::.:|....|..|.||.:..|:.|.:.....|..::|.|......|
Frog   247 KFIHVPSVALQKVVNLKFLDLNKNPVRRIQRGDFSNMLHLKELGINNMPELVSIDSLAIENLPEL 311

  Fly   340 EHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLV-PWADLQTLDLSENPFECDCRL 403
            ..:..::|.:|..:...|...||.|.|::|.:|.||::....: ...:|:.:.:..||..|||.:
Frog   312 RKIEATNNPKLAYIHPNAFYRLPKLETLMLNSNSLSAIYRSTIEALPNLKEISIHSNPMRCDCVI 376

  Fly   404 LWL 406
            .|:
Frog   377 RWI 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	5/20 (25%)
		LRR_8	96..155	CDD:290566	15/58 (26%)
		leucine-rich repeat	97..120	CDD:275380	9/22 (41%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_8	143..201	CDD:290566	14/57 (25%)
		leucine-rich repeat	145..168	CDD:275380	0/22 (0%)
		LRR_RI	147..397	CDD:238064	66/250 (26%)
		leucine-rich repeat	169..192	CDD:275380	10/22 (45%)
		leucine-rich repeat	193..217	CDD:275380	7/23 (30%)
		LRR_8	217..276	CDD:290566	19/58 (33%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	9/22 (41%)
		LRR_8	265..321	CDD:290566	15/55 (27%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		LRR_8	312..374	CDD:290566	15/61 (25%)
		leucine-rich repeat	314..335	CDD:275380	5/20 (25%)
		leucine-rich repeat	339..363	CDD:275380	5/23 (22%)
		LRRCT	395..445	CDD:214507	6/12 (50%)
lrrn3	NP_001072526.1	leucine-rich repeat	52..70	CDD:275380	5/17 (29%)
		leucine-rich repeat	71..93	CDD:275380	5/21 (24%)
		leucine-rich repeat	94..117	CDD:275380	9/22 (41%)
		leucine-rich repeat	118..141	CDD:275380	6/46 (13%)
		LRR_8	120..176	CDD:290566	21/79 (27%)
		leucine-rich repeat	142..165	CDD:275380	10/22 (45%)
		LRR_8	164..221	CDD:290566	18/57 (32%)
		leucine-rich repeat	166..189	CDD:275380	7/23 (30%)
		leucine-rich repeat	190..213	CDD:275380	7/22 (32%)
		LRR_8	213..272	CDD:290566	18/58 (31%)
		leucine-rich repeat	214..237	CDD:275380	9/22 (41%)
		leucine-rich repeat	238..261	CDD:275380	6/22 (27%)
		leucine-rich repeat	262..285	CDD:275380	7/22 (32%)
		leucine-rich repeat	286..310	CDD:275380	5/23 (22%)
		LRR_8	309..370	CDD:290566	14/60 (23%)
		leucine-rich repeat	311..333	CDD:275380	4/21 (19%)
		leucine-rich repeat	336..359	CDD:275378	6/22 (27%)
		leucine-rich repeat	360..372	CDD:275378	3/11 (27%)
		TPKR_C2	368..419	CDD:301599	6/12 (50%)
		I-set	429..513	CDD:254352
		IGc2	437..503	CDD:197706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11458
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	166	1.000	Inparanoid score	I4049
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm14097
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.960