DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and Lrrtm1

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001349038.1	Gene:	Lrrtm1 / 74342	MGIID:	2389173	Length:	522	Species:	Mus musculus

Alignment Length:	457	Identity:	113/457 - (24%)
Similarity:	172/457 - (37%)	Gaps:	123/457 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LCLCL----------CLCLVLA---TLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNP 72
            |.|||          .|||:.|   .||.|  .:.||..|.|:...|...           |||
Mouse     6 LGLCLHWLLRRPSGVVLCLLGACFQMLPAA--PSGCPGQCRCEGRLLYCE-----------ALN- 56

  Fly    73 AIQRLVIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNK 137
                          :..:....:.|..|.|.:|.:..:....|....:|..|:||||.|..|...
Mouse    57 --------------LTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGD 107

  Fly   138 TFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNT 202
            .|..|..:..|.|..|.|.||...||.||..|..::|..|::..:.|....||..|..|::..|.
Mouse   108 AFQKLRRVKELTLSSNQITELANTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANA 172

  Fly   203 LTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLR 267
            :..||..:                         |||.:                        ||:
Mouse   173 IQFVPVRI-------------------------FQDCR------------------------SLK 188

  Fly   268 FLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRR----V 328
            |||:..|:|.::...:|..|.:|.:|::..||...::...|..|..|..|      .|||    :
Mouse   189 FLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLIKVNFAHFPRLISLHSL------CLRRNKVAI 247

  Fly   329 ESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLV-PWADLQTLDL 392
            ...:.....|||.::||.| ::..:.......:|:|.|:.|.:|:|:.::..:: .|..|.::.|
Mouse   248 VVSSLDWVWNLEKMDLSGN-EIEYMEPHVFETVPYLQTLQLDSNRLTYIEPRILNSWKSLTSITL 311

  Fly   393 SENPFECD---CRLL-WLRHLLVSRNASGQY-APVICAYP------TALRDLPLAHL----AEPL 442
            :.|.::|.   |.|. ||      .|..|:| |.:.||.|      ..|..:...||    |||.
Mouse   312 AGNLWDCGRNVCALASWL------SNFQGRYDANLQCASPEYAQGEDVLDAVYAFHLCEDGAEPT 370

  Fly   443 LG 444
            .|
Mouse   371 SG 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	0/20 (0%)
		LRR_8	96..155	CDD:290566	18/58 (31%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	10/22 (45%)
		LRR_8	143..201	CDD:290566	18/57 (32%)
		leucine-rich repeat	145..168	CDD:275380	10/22 (45%)
		LRR_RI	147..397	CDD:238064	60/254 (24%)
		leucine-rich repeat	169..192	CDD:275380	6/22 (27%)
		leucine-rich repeat	193..217	CDD:275380	5/23 (22%)
		LRR_8	217..276	CDD:290566	9/58 (16%)
		leucine-rich repeat	218..241	CDD:275380	3/22 (14%)
		leucine-rich repeat	242..265	CDD:275380	0/22 (0%)
		LRR_8	265..321	CDD:290566	17/55 (31%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		LRR_8	312..374	CDD:290566	16/65 (25%)
		leucine-rich repeat	314..335	CDD:275380	5/24 (21%)
		leucine-rich repeat	339..363	CDD:275380	5/23 (22%)
		LRRCT	395..445	CDD:214507	20/65 (31%)
Lrrtm1	NP_001349038.1	LRR 1	64..87		5/22 (23%)
		LRR	<75..>315	CDD:227223	71/295 (24%)
		LRR 2	89..111		9/21 (43%)
		leucine-rich repeat	91..114	CDD:275380	10/22 (45%)
		LRR 3	112..135		9/22 (41%)
		leucine-rich repeat	115..138	CDD:275380	10/22 (45%)
		LRR 4	136..159		5/22 (23%)
		leucine-rich repeat	139..162	CDD:275380	6/22 (27%)
		LRR 5	161..183		6/46 (13%)
		leucine-rich repeat	163..186	CDD:275380	8/71 (11%)
		LRR 6	184..207		8/46 (17%)
		leucine-rich repeat	187..210	CDD:275380	8/22 (36%)
		LRR 7	209..231		5/21 (24%)
		leucine-rich repeat	211..234	CDD:275380	6/22 (27%)
		LRR 8	233..255		5/27 (19%)
		leucine-rich repeat	235..257	CDD:275380	5/27 (19%)
		LRR 9	256..278		6/22 (27%)
		leucine-rich repeat	258..281	CDD:275380	5/23 (22%)
		LRR 10	280..302		6/21 (29%)
		leucine-rich repeat	282..300	CDD:275380	5/17 (29%)
		leucine-rich repeat	306..318	CDD:275378	3/11 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910