DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and Flrt3

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001165631.1	Gene:	Flrt3 / 71436	MGIID:	1918686	Length:	649	Species:	Mus musculus

Alignment Length:	427	Identity:	100/427 - (23%)
Similarity:	164/427 - (38%)	Gaps:	98/427 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LVLATLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRLVIKNNKLKTIDSSMQF 93
            |.....|:::...:||:.|.||..  .:.|.:.:|..:|:.:......|.::||::..:.
Mouse    17 LFFQVAPLSVVAKSCPSVCRCDAG--FIYCNDRSLTSIPVGIPEDATTLYLQNNQINNVG----- 74

  Fly    94 YAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLIAEL 158
                  :.....::|.: :|.:.||..|.|...:..|.             :..|:|:.|.|..:
Mouse    75 ------IPSDLKNLLKV-QRIYLYHNSLDEFPTNLPKY-------------VKELHLQENNIRTI 119

  Fly   159 EYRTFSPMVKLAELNLGQNRIS--HIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHSLAEL 221
            .|.:.|.:..|.||:|..|.:|  .|:..|....:.||:|:|..|.|:|:||.|.    .::.||
Mouse   120 TYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPGGLP----RTIEEL 180

  Fly   222 YLGTNSFMTIPGGAFQDLKGLTRLDLRGAGL--HNISGDALKGLVSLRFLDLSDNRLPAIP---- 280
            .|..|...||...:...|..|.||.|.|..|  |.:.......||:|..|.|..|.|.|.|
Mouse   181 RLDDNRISTISSPSLHGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLP 245

  Fly   281 -TAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNL 344
             |:       |.:|.:..|....:...|||.||:|..|:::.
Mouse   246 GTS-------LRKLYLQDNHINRVPPNAFSYLRQLYRLDMSN----------------------- 280

  Fly   345 SSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWAD-LQTLDLSENPFECDCRLLWLRH 408
                                       |.||:|.:|:....| :..|.|..||:.|.|::.|:|.
Mouse   281 ---------------------------NNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRD 318

  Fly   409 LLVSRNASGQYAPVICAYPTALRDLPLAHLAEPLLGC 445
            .|.|.........::|..|..:|.:.:..|:..|..|
Mouse   319 WLQSLPVKVNVRGLMCQAPEKVRGMAIKDLSAELFDC 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	3/20 (15%)
		LRR_8	96..155	CDD:290566	10/58 (17%)
		leucine-rich repeat	97..120	CDD:275380	4/22 (18%)
		leucine-rich repeat	121..144	CDD:275380	3/22 (14%)
		LRR_8	143..201	CDD:290566	18/59 (31%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		LRR_RI	147..397	CDD:238064	67/259 (26%)
		leucine-rich repeat	169..192	CDD:275380	8/24 (33%)
		leucine-rich repeat	193..217	CDD:275380	10/23 (43%)
		LRR_8	217..276	CDD:290566	20/60 (33%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	8/24 (33%)
		LRR_8	265..321	CDD:290566	18/60 (30%)
		leucine-rich repeat	266..289	CDD:275380	8/27 (30%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		LRR_8	312..374	CDD:290566	4/61 (7%)
		leucine-rich repeat	314..335	CDD:275380	2/20 (10%)
		leucine-rich repeat	339..363	CDD:275380	0/23 (0%)
		LRRCT	395..445	CDD:214507	13/49 (27%)
Flrt3	NP_001165631.1	LRRNT	31..61	CDD:214470	8/31 (26%)
		Interaction with ADGRL3. /evidence=ECO:0000250\|UniProtKB:Q9NZU0	38..67		5/30 (17%)
		LRR 1. /evidence=ECO:0000255	58..82		3/34 (9%)
		LRR_4	61..100	CDD:289563	9/50 (18%)
		leucine-rich repeat	61..84	CDD:275378	3/33 (9%)
		LRR 2. /evidence=ECO:0000255	83..105		6/22 (27%)
		leucine-rich repeat	85..104	CDD:275380	5/19 (26%)
		LRR_8	106..166	CDD:290566	19/59 (32%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		LRR_RI	107..327	CDD:238064	74/280 (26%)
		LRR 3. /evidence=ECO:0000255	107..126		5/18 (28%)
		LRR 4. /evidence=ECO:0000255	127..152		8/24 (33%)
		leucine-rich repeat	130..155	CDD:275380	8/24 (33%)
		LRR 5. /evidence=ECO:0000255	153..176		10/26 (38%)
		leucine-rich repeat	156..176	CDD:275380	10/23 (43%)
		LRR_8	175..237	CDD:290566	20/61 (33%)
		leucine-rich repeat	177..200	CDD:275380	7/22 (32%)
		LRR 6. /evidence=ECO:0000255	178..197		6/18 (33%)
		LRR 7. /evidence=ECO:0000255	198..223		8/24 (33%)
		leucine-rich repeat	201..226	CDD:275380	8/24 (33%)
		LRR 8. /evidence=ECO:0000255	224..246		9/21 (43%)
		leucine-rich repeat	227..248	CDD:275380	7/20 (35%)
		LRR_8	247..306	CDD:290566	19/115 (17%)
		LRR 9. /evidence=ECO:0000255	247..269		6/28 (21%)
		leucine-rich repeat	249..272	CDD:275380	7/22 (32%)
		LRR 10. /evidence=ECO:0000255	270..293		9/72 (13%)
		leucine-rich repeat	273..296	CDD:275380	7/72 (10%)
		LRRCT	305..356	CDD:214507	14/51 (27%)
		fn3	413..478	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..649
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870