DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment caps and LRRTM1

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001382551.1	Gene:	LRRTM1 / 679668	RGDID:	1585921	Length:	523	Species:	Rattus norvegicus

Alignment Length:	635	Identity:	142/635 - (22%)
Similarity:	216/635 - (34%)	Gaps:	202/635 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LCLCL----------CLCLVLA---TLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNP 72
            |.|||          .|||:.|   .||.|  .:.||..|.|:...|...           |||
  Rat     6 LGLCLHWLLRRPSGVVLCLLGACFQMLPAA--PSGCPGQCRCEGRLLYCE-----------ALN- 56

  Fly    73 AIQRLVIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNK 137
                          :..:....:.|..|.|.:|.:..:....|....:|..|:||||.|..|...
  Rat    57 --------------LTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGD 107

  Fly   138 TFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNT 202
            .|..|..:..|.|..|.|.||...||.||..|..::|..|::..:.|....||..|..|::..|.
  Rat   108 AFQKLRRVKELTLSSNQITELANTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANA 172

  Fly   203 LTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLR 267
            :..||..:                         |||.:                        ||:
  Rat   173 IQFVPVRI-------------------------FQDCR------------------------SLK 188

  Fly   268 FLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRR----V 328
            |||:..|:|.::...:|..|.:|.:|::..||...::...|..|..|..|      .|||    :
  Rat   189 FLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLIKVNFAHFPRLISLNSL------CLRRNKVAI 247

  Fly   329 ESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLV-PWADLQTLDL 392
            ...:.....|||.::||.| ::..:.......:|:|.::.|.:|:|:.::..:: .|..|.::.|
  Rat   248 VVSSLDWVWNLEKMDLSGN-EIEYMEPHVFETVPYLQSLQLDSNRLTYIEPRILNSWKSLTSITL 311

  Fly   393 SENPFECD---CRLL-WLRHLLVSRNASGQY-APVICAYP------TALRDLPLAHLAEPLLGCA 446
            :.|.::|.   |.|. ||      .|..|:| |.:.||.|      ..|..:...||      |.
  Rat   312 AGNLWDCGRNVCALASWL------SNFQGRYDANLQCASPEYAQGEDVLDAVYAFHL------CE 364

  Fly   447 HGAASKQAIIGILVVACAALITTLALVLYTCRHRIREMLKGHSALGRKEREYQKTFSDEEYMSRP 511
            .||..                        |..|.:...:...|.|...|.. ..|..|
  Rat   365 DGAEP------------------------TSGHLLSAAVTNRSDLAPPESS-ATTLVD------- 397

  Fly   512 PPGGGGVHPAAGGYPYIAGNSRMIPVTELXLEAPPPPQLRGRGGGGGASTASGAVQQLQVPSAVD 576
              ||.|:|           :|.:.|:|    .|.|           |...|..|||..:|.:...
  Rat   398 --GGEGLH-----------DSTLEPIT----VAIP-----------GGEHAENAVQIHKVVTGTM 434

  Fly   577 QASNSF---------------AQLSHIH--YMTNNGQQQQAQQQQSTSKM 609
            ....||               |.|..:.  ::|...:|:|.|.....:.|
  Rat   435 ALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTMHQMAAM 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	0/20 (0%)
		LRR_8	96..155	CDD:290566	18/58 (31%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	10/22 (45%)
		LRR_8	143..201	CDD:290566	18/57 (32%)
		leucine-rich repeat	145..168	CDD:275380	10/22 (45%)
		LRR_RI	147..397	CDD:238064	59/254 (23%)
		leucine-rich repeat	169..192	CDD:275380	6/22 (27%)
		leucine-rich repeat	193..217	CDD:275380	5/23 (22%)
		LRR_8	217..276	CDD:290566	9/58 (16%)
		leucine-rich repeat	218..241	CDD:275380	3/22 (14%)
		leucine-rich repeat	242..265	CDD:275380	0/22 (0%)
		LRR_8	265..321	CDD:290566	17/55 (31%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		LRR_8	312..374	CDD:290566	15/65 (23%)
		leucine-rich repeat	314..335	CDD:275380	5/24 (21%)
		leucine-rich repeat	339..363	CDD:275380	5/23 (22%)
		LRRCT	395..445	CDD:214507	16/60 (27%)
LRRTM1	NP_001382551.1	LRR 1	64..87		5/22 (23%)
		LRR 2	89..111		9/21 (43%)
		LRR 3	112..135		9/22 (41%)
		LRR 4	136..159		5/22 (23%)
		LRR 5	161..183		6/46 (13%)
		LRR 6	184..207		8/46 (17%)
		LRR 7	209..231		5/21 (24%)
		LRR 8	233..255		5/27 (19%)
		LRR 9	256..278		6/22 (27%)
		LRR 10	280..302		5/21 (24%)
		May be involved in DLG4-binding. /evidence=ECO:0000250	520..523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000