DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and Lrrc4

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001032413.1	Gene:	Lrrc4 / 641521	RGDID:	1560026	Length:	652	Species:	Rattus norvegicus

Alignment Length:	747	Identity:	169/747 - (22%)
Similarity:	243/747 - (32%)	Gaps:	262/747 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LCLVLATLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRLVIKNNKLKTIDSSM 91
            ||..:|....| |..|||:.|.|.:....|.|....|..:|                 :.|.|:.
  Rat    30 LCAAIAAAASA-GPQNCPSVCSCSNQFSKVVCTRRGLSEVP-----------------QGIPSNT 76

  Fly    92 QFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLIA 156
            ::                                                      |||..|.|.
  Rat    77 RY------------------------------------------------------LNLMENNIQ 87

  Fly   157 ELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHSLAEL 221
            .::..||..:..|..|.||:|.|..|:..|.:||.:|..|.|.||.||.:|.. .|:.|..|.||
  Rat    88 MIQADTFRHLHHLEVLQLGRNAIRQIEVGAFNGLASLNTLELFDNWLTVIPSG-AFEYLSKLREL 151

  Fly   222 YLGTNSFMTIPGGAFQDLKGLTRLDLRGAG----LHNISGDALKGLVSLRFLDLSDNRLPAIPTA 282
            :|..|...:||..||..:..|.||||   |    |..||..|.:||.:|::|:|....:..:|.
  Rat   152 WLRNNPIESIPSYAFNRVPSLMRLDL---GELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPN- 212

  Fly   283 AFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSN 347
             ...|..||:|.:..|.|..|..|:|.||..|:.|.:..:| :..:|..||.|..:|..|||:.|
  Rat   213 -LTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQ-VSLIERNAFDGLASLVELNLAHN 275

  Fly   348 KQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWADLQTLDLSENPFECDCRLLWL------ 406
            .         |..|||               :...|...|..|.|..||:.|||.:|||
  Rat   276 N---------LSSLPH---------------DLFTPLRYLVELHLHHNPWNCDCDILWLAWWLRE 316

  Fly   407 --------------------RHLLVSRNASGQ-YAPVICAYPTALRDLPLA--HLAEPLLGC--- 445
                                |:|:....||.| .||.|...|   |||.::  .:||  |.|
  Rat   317 YIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAP---RDLNISEDRMAE--LKCRTP 376

  Fly   446 ---------------AHGAASKQAII---GILVVACAALITTLALVLYTC-------RHRIREML 485
                           :|.:...:..:   |.|..:...||.|   .:|||       .......|
  Rat   377 PMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSRVLLIDT---GVYTCMVTNVAGNSNASAYL 438

  Fly   486 KGHSA-LGRKEREYQKTFSDEEYMSRP----------PPGGGGVHPAAGGYPYIAGNSRMIPVTE 539
            ...|| |......:..|.:.|.....|          |....|..||     |....:.:|..|.
  Rat   439 NVSSAELNTPNFSFFTTVTVETTEISPEDITRKYKPVPTTSTGYQPA-----YTTSTTVLIQTTR 498

  Fly   540 LXLEAPPPP----------------------------------------QLRGRGGGGGASTASG 564
            : .:.|.|.                                        :||.|.......||:.
  Rat   499 VPKQVPVPSTDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTVTAAR 563

  Fly   565 AVQQLQVPSAVDQASNSFAQLS-----------------HIHYMTNNGQQQQAQQQQSTSKMHHS 612
            .|:.:||...:..|:::.|..:                 ||:|.|          .:.....|.:
  Rat   564 TVEIIQVDEDIPAAASAAATAAPSGVSGEGAVVLPTIHDHINYNT----------YKPAHGAHWT 618

  Fly   613 QQDMRLLACNGGKPLNATSLPRHRPPVVQEST 644
            :..:       |..|:.|......|.::|..|
  Rat   619 ENSL-------GNSLHPTVTTISEPYIIQTHT 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	2/20 (10%)
		LRR_8	96..155	CDD:290566	4/58 (7%)
		leucine-rich repeat	97..120	CDD:275380	0/22 (0%)
		leucine-rich repeat	121..144	CDD:275380	0/22 (0%)
		LRR_8	143..201	CDD:290566	20/57 (35%)
		leucine-rich repeat	145..168	CDD:275380	7/22 (32%)
		LRR_RI	147..397	CDD:238064	84/253 (33%)
		leucine-rich repeat	169..192	CDD:275380	10/22 (45%)
		leucine-rich repeat	193..217	CDD:275380	10/23 (43%)
		LRR_8	217..276	CDD:290566	24/62 (39%)
		leucine-rich repeat	218..241	CDD:275380	9/22 (41%)
		leucine-rich repeat	242..265	CDD:275380	12/26 (46%)
		LRR_8	265..321	CDD:290566	17/55 (31%)
		leucine-rich repeat	266..289	CDD:275380	5/22 (23%)
		leucine-rich repeat	290..313	CDD:275380	10/22 (45%)
		LRR_8	312..374	CDD:290566	16/61 (26%)
		leucine-rich repeat	314..335	CDD:275380	6/20 (30%)
		leucine-rich repeat	339..363	CDD:275380	7/23 (30%)
		LRRCT	395..445	CDD:214507	23/78 (29%)
Lrrc4	NP_001032413.1	LRRNT	45..78	CDD:214470	10/49 (20%)
		LRR_8	74..132	CDD:404697	21/111 (19%)
		LRR 1	75..96		7/74 (9%)
		leucine-rich repeat	76..99	CDD:275380	7/76 (9%)
		PPP1R42	96..300	CDD:411060	76/234 (32%)
		LRR 2	99..120		8/20 (40%)
		leucine-rich repeat	100..123	CDD:275380	10/22 (45%)
		LRR 3	123..144		9/21 (43%)
		leucine-rich repeat	124..147	CDD:275380	10/23 (43%)
		LRR 4	147..168		9/20 (45%)
		leucine-rich repeat	148..171	CDD:275380	9/22 (41%)
		LRR 5	171..193		10/24 (42%)
		leucine-rich repeat	172..196	CDD:275380	12/26 (46%)
		LRR 6	196..217		4/22 (18%)
		leucine-rich repeat	197..218	CDD:275380	5/22 (23%)
		LRR 7	218..239		8/20 (40%)
		leucine-rich repeat	219..242	CDD:275380	10/22 (45%)
		LRR 8	242..263		6/21 (29%)
		leucine-rich repeat	243..266	CDD:275380	7/23 (30%)
		LRR 9	266..287		9/44 (20%)
		leucine-rich repeat	267..288	CDD:275380	9/44 (20%)
		LRRCT	299..350	CDD:214507	13/50 (26%)
		IG_like	358..440	CDD:214653	18/89 (20%)
		Ig strand B	369..373	CDD:409353	3/5 (60%)
		Ig strand C	380..384	CDD:409353	0/3 (0%)
		Ig strand E	406..410	CDD:409353	2/3 (67%)
		Ig strand F	420..425	CDD:409353	3/4 (75%)
		Ig strand G	433..436	CDD:409353	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910