DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment caps and flrt3

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001243575.1	Gene:	flrt3 / 558864	ZFINID:	ZDB-GENE-030131-1988	Length:	649	Species:	Danio rerio

Alignment Length:	749	Identity:	168/749 - (22%)
Similarity:	273/749 - (36%)	Gaps:	242/749 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LGLAN-------CPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRLVIKNNKLKT--IDSSMQF 93
            |||||       ||:.|.||.  ..:.|.:..|..:|..:......|.::||::|:  |.:.::.
Zfish    19 LGLANPLMTSASCPSQCRCDG--TFIYCNDRDLTSIPSGIPEDATVLFLQNNRIKSAGIPTDLRR 81

  Fly    94 YAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLIAEL 158
            ...:..:.|..|::...|..   ....::||||..|.|..:::.:                :|::
Zfish    82 LNGVEKIYLYCNNLDEFPTN---LPLNVKELHLQENNIRTITHAS----------------LAQI 127

  Fly   159 EYRTFSPMVKLAELNLGQNRIS--HIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHSLAEL 221
            .:        :.||:|..|.:|  .|:..|....::||:|:|..|.|:|:|..|..    ::.||
Zfish   128 PF--------IEELHLDDNSVSAVSIEEGAFRDSNHLRLLFLSRNHLSTIPSGLPM----TIEEL 180

  Fly   222 YLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHN--ISGDALKGLVSLRFLDLSDNRL---PA-IP 280
            ....|...:|...:.|||..|.||.|.|..|:|  |...||..||:|..|.|..|.|   || :|
Zfish   181 RFDDNRISSISEASLQDLINLKRLVLDGNLLNNRGIGEMALVNLVNLTELSLVRNSLTSPPANLP 245

  Fly   281 TAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLS 345
            .::      ||:||:..|....:..|||:.||:|..|:|:|
Zfish   246 GSS------LEKLNLQDNHINHVPPGAFAFLRQLYRLDLSG------------------------ 280

  Fly   346 SNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWADLQTLDLSENPFECDCRLLWLRHLL 410
                 |.|||:.:|....|.                    :|..|.|..||:.|:||:.|:|..|
Zfish   281 -----NNLSSLPMGVFEDLD--------------------NLTQLLLRNNPWHCNCRMKWVRDWL 320

  Fly   411 VSRNASGQYAPVICAYPTALRDLPLAHLAEPLLGCA----------------------------- 446
            .:..:.......:|..|..::.:.:..|:..|.||:
Zfish   321 RTLPSKVNVRGFMCQGPDKVKGMAIKDLSTELFGCSDTEIPTTYETSTVSNTLPPSRPQWPSYVT 385

  Fly   447 ---------------HGAASKQAIIGILVVACAA-----------LITTLALVLYTCRHRIREML 485
                           ....|.:.||.|.|.:.:|           .:|.|         |:..:.
Zfish   386 KRPVVKGPDLGRNYRSTTPSSRKIITISVKSSSAETVHISWRVSQPMTAL---------RLSWLK 441

  Fly   486 KGHS-ALG-------RKER-EYQKTFSDEE---------------YMSRPPPGGGGVHPAAGGYP 526
            .||| |.|       :.|| ||..|..:.|               |:|...|  ..:....|...
Zfish   442 LGHSPAFGSITETIVQGERTEYLLTALEPESSYRICMVPMETSNIYLSDETP--VCIETETGSLK 504

  Fly   527 YIAGNSRMIPVTELXLEAPPPP------QLRGRGGGGGASTASGAVQQLQVPSA------VDQAS 579
              |.|    |.|.|..|....|      .|        ||...|||..|.:...      |.:..
Zfish   505 --AYN----PTTTLNREQEKEPYKNSNLPL--------ASIIGGAVALLAIIMLALVCWYVHRNG 555

  Fly   580 NSFAQLSHIHYMTNNGQQQQAQQQQSTSKMHHSQQDMRLLACNGGKPLNATS---LPRHRPPVVQ 641
            :.|::    :...|.|::::....::.:|..:|..::|           .||   :|.:..||.:
Zfish   556 SLFSR----NCTYNKGRRRKDDYAEAGTKKDNSILEIR-----------ETSFQMIPINHMPVSK 605

  Fly   642 ESTLSHYSQPLANGIRLTQDHFNHNQNQSHNQHY 675
            |..:.|...| .||:.|.:.  .|::|..:|:.|
Zfish   606 EEFVIHTIFP-PNGLSLYKS--PHSENSINNRSY 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	5/22 (23%)
		LRR_8	96..155	CDD:290566	9/58 (16%)
		leucine-rich repeat	97..120	CDD:275380	3/22 (14%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_8	143..201	CDD:290566	12/59 (20%)
		leucine-rich repeat	145..168	CDD:275380	1/22 (5%)
		LRR_RI	147..397	CDD:238064	68/257 (26%)
		leucine-rich repeat	169..192	CDD:275380	7/24 (29%)
		leucine-rich repeat	193..217	CDD:275380	9/23 (39%)
		LRR_8	217..276	CDD:290566	23/60 (38%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	11/24 (46%)
		LRR_8	265..321	CDD:290566	21/59 (36%)
		leucine-rich repeat	266..289	CDD:275380	8/26 (31%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		LRR_8	312..374	CDD:290566	11/61 (18%)
		leucine-rich repeat	314..335	CDD:275380	4/20 (20%)
		leucine-rich repeat	339..363	CDD:275380	5/23 (22%)
		LRRCT	395..445	CDD:214507	12/49 (24%)
flrt3	NP_001243575.1	LRRNT	31..61	CDD:214470	8/31 (26%)
		leucine-rich repeat	61..84	CDD:275378	5/22 (23%)
		leucine-rich repeat	85..105	CDD:275380	3/22 (14%)
		LRR_RI	104..327	CDD:238064	81/305 (27%)
		leucine-rich repeat	106..129	CDD:275380	7/38 (18%)
		leucine-rich repeat	130..155	CDD:275380	7/24 (29%)
		LRR_8	131..211	CDD:290566	28/83 (34%)
		leucine-rich repeat	156..176	CDD:275380	9/23 (39%)
		leucine-rich repeat	177..200	CDD:275380	7/22 (32%)
		LRR_8	178..237	CDD:290566	23/58 (40%)
		leucine-rich repeat	201..226	CDD:275380	11/24 (46%)
		leucine-rich repeat	227..248	CDD:275380	8/20 (40%)
		LRR_8	247..306	CDD:290566	23/113 (20%)
		leucine-rich repeat	249..272	CDD:275380	9/22 (41%)
		leucine-rich repeat	273..296	CDD:275380	10/71 (14%)
		LRRCT	305..356	CDD:214507	13/50 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	1	0.960