DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and si:dkey-90m5.4

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001038237.1	Gene:	si:dkey-90m5.4 / 553466	ZFINID:	ZDB-GENE-041014-250	Length:	327	Species:	Danio rerio

Alignment Length:	439	Identity:	104/439 - (23%)
Similarity:	160/439 - (36%)	Gaps:	128/439 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LGQAFSLCLCLCLCLVLATLPVALGLANCPNGCEC--DDDTLMVNCGEGTLDVLP-IALNPAIQR 76
            |.:|.::.|.||          :....:||..|.|  ...|..|.|.:..|...| ..|.|:...
Zfish     5 LVRALAVMLVLC----------SRDALSCPKRCTCHFSAKTTEVVCPDAGLSHFPGDGLPPSTTS 59

  Fly    77 LVIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLG 141
            |.|:...|..:.|               ..:..:|        .|:||||..||:..:.......
Zfish    60 LTIQFTNLTVLTS---------------EHLRAVP--------LLEELHLPGNKLSSLPADILKD 101

  Fly   142 LSTISVLNLRGNLIAELEYRTF--SPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLT 204
            |..:..::|..|.:.||....|  :|::.|.   |..||||:|.|   |...|
Zfish   102 LKYLHTIDLTDNELRELPEYVFRHAPLLNLV---LKDNRISNIHP---DWFPN------------ 148

  Fly   205 TVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFL 269
                                 ||                                     :|.:|
Zfish   149 ---------------------NS-------------------------------------NLTWL 155

  Fly   270 DLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFS 334
            |||.|:|...|.|..|.|..|:.|::.||..|.:..|.......|..|.| ...:::.::..|||
Zfish   156 DLSGNQLMKFPMAQLQNLRHLKVLHLSQNKIEELPVGCLDAHTALERLYL-DQNKIQTLDVKAFS 219

  Fly   335 GNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWADLQT--LDLSENPF 397
            |:|||.|:.|..|: ::.|.......|..|..|.|..|:|..|..|::   |:.|  ::|:.||:
Zfish   220 GSTNLTHIFLQKNR-IDSLPPTVFQELKRLEYVDLSDNRLQFLSPGIL---DINTSWVELTFNPW 280

  Fly   398 ECDCRL--LWLRHLLVSRNASGQYAPVICAYPTALRDLPLAHLAEPLLG 444
            .||.::  ||.:..:.|..:..:     ||.|..|:|..:|.|....:|
Zfish   281 HCDAKIEYLWRKITMESLQSEPK-----CAAPENLKDRVIATLTRKDMG 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	4/20 (20%)
		LRR_8	96..155	CDD:290566	11/58 (19%)
		leucine-rich repeat	97..120	CDD:275380	1/22 (5%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR_8	143..201	CDD:290566	16/59 (27%)
		leucine-rich repeat	145..168	CDD:275380	6/24 (25%)
		LRR_RI	147..397	CDD:238064	61/253 (24%)
		leucine-rich repeat	169..192	CDD:275380	9/22 (41%)
		leucine-rich repeat	193..217	CDD:275380	0/23 (0%)
		LRR_8	217..276	CDD:290566	8/58 (14%)
		leucine-rich repeat	218..241	CDD:275380	2/22 (9%)
		leucine-rich repeat	242..265	CDD:275380	0/22 (0%)
		LRR_8	265..321	CDD:290566	20/55 (36%)
		leucine-rich repeat	266..289	CDD:275380	11/22 (50%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		LRR_8	312..374	CDD:290566	19/61 (31%)
		leucine-rich repeat	314..335	CDD:275380	5/20 (25%)
		leucine-rich repeat	339..363	CDD:275380	6/23 (26%)
		LRRCT	395..445	CDD:214507	15/52 (29%)
si:dkey-90m5.4	NP_001038237.1	LRR_8	55..115	CDD:404697	16/82 (20%)
		leucine-rich repeat	57..80	CDD:275380	5/45 (11%)
		leucine-rich repeat	81..104	CDD:275380	8/22 (36%)
		PPP1R42	102..279	CDD:411060	61/257 (24%)
		leucine-rich repeat	105..126	CDD:275380	5/20 (25%)
		leucine-rich repeat	128..151	CDD:275380	12/98 (12%)
		leucine-rich repeat	152..175	CDD:275380	11/22 (50%)
		leucine-rich repeat	176..199	CDD:275380	6/22 (27%)
		leucine-rich repeat	200..223	CDD:275380	7/23 (30%)
		leucine-rich repeat	224..247	CDD:275380	6/23 (26%)
		leucine-rich repeat	248..271	CDD:275380	8/25 (32%)
		TPKR_C2	278..319	CDD:417692	13/45 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100