DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and Lingo4

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001102659.1	Gene:	Lingo4 / 499668	RGDID:	1562025	Length:	618	Species:	Rattus norvegicus

Alignment Length:	454	Identity:	138/454 - (30%)
Similarity:	198/454 - (43%)	Gaps:	49/454 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RRRAITMSLAPHLGQAFSLCLCLCLCLVLATLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLP 67
            |.:.:..:.||.  ||:.|...|   |.|..||.. .:::||..|:|...|..|.|....||.:|
  Rat    22 RPQGMDAATAPK--QAWLLWSPL---LFLLLLPGG-SISSCPTLCDCTSQTRAVLCAHRRLDTVP 80

  Fly    68 IALNPAIQRLVIKNNKLKTIDSSM-QFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKI 131
            ..|....:.|.:..|:|..:...| ....||..||||:|.:.|:...:|.....|..|.|..|::
  Rat    81 GGLPLDTEVLDLSGNRLWGLQRGMLSRLGQLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRL 145

  Fly   132 GQVSNKTFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVL 196
            ..|....|.|||.:::|:||.|.|.......|..:..|.:|.:|.|.:..:.|.|..||..|..:
  Rat   146 RIVGPGIFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQQLEVGDNHLVFVAPGAFSGLAKLSTI 210

  Fly   197 YLDDNTLTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDL-RGAGLHNISGDAL 260
            .|:...|:|||| |....|.:|..|.|.......:|.||.:.|..|..|:: ....|..:...:|
  Rat   211 TLERCNLSTVPG-LALAQLPALVALRLRELDIERLPSGALRGLGQLKELEIHHWPSLEALDPGSL 274

  Fly   261 KGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRL 325
            .|| :|..|.::...|.::|..|...|..|:.|::.||....|.:...|.|..|:.|.|:|| .|
  Rat   275 VGL-NLSSLAITHCNLSSVPFQALHHLSFLQVLDLSQNPISAIPARRLSPLVRLQELRLSGA-CL 337

  Fly   326 RRVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWAD-LQT 389
            ..:.:.||.|.|....|:::.                         |.|.:|:|...|..| |.|
  Rat   338 TSIAAHAFHGLTAFHLLDVAD-------------------------NALQTLEETAFPSPDKLVT 377

  Fly   390 LDLSENPFECDCRLLWLRHLLVSRNASGQYAPVICAYP-----TALRD----LPLAHL-AEPLL 443
            |.||.||..||||||||  |.:.|......:|..||.|     ..||:    ||..|. .:|.|
  Rat   378 LRLSGNPLTCDCRLLWL--LRLRRRLDFGTSPPACAGPQHVQGKNLREFSDILPPGHFTCKPAL 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	4/21 (19%)
		LRR_8	96..155	CDD:290566	22/58 (38%)
		leucine-rich repeat	97..120	CDD:275380	8/22 (36%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR_8	143..201	CDD:290566	17/57 (30%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		LRR_RI	147..397	CDD:238064	72/251 (29%)
		leucine-rich repeat	169..192	CDD:275380	8/22 (36%)
		leucine-rich repeat	193..217	CDD:275380	9/23 (39%)
		LRR_8	217..276	CDD:290566	15/59 (25%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	6/23 (26%)
		LRR_8	265..321	CDD:290566	16/55 (29%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		LRR_8	312..374	CDD:290566	12/61 (20%)
		leucine-rich repeat	314..335	CDD:275380	8/20 (40%)
		leucine-rich repeat	339..363	CDD:275380	1/23 (4%)
		LRRCT	395..445	CDD:214507	23/59 (39%)
Lingo4	NP_001102659.1	leucine-rich repeat	87..110	CDD:275380	4/22 (18%)
		LRR_8	88..145	CDD:290566	17/56 (30%)
		LRR_4	88..126	CDD:289563	12/37 (32%)
		LRR_RI	110..345	CDD:238064	73/237 (31%)
		leucine-rich repeat	111..134	CDD:275380	8/22 (36%)
		LRR_8	134..193	CDD:290566	19/58 (33%)
		leucine-rich repeat	135..158	CDD:275380	8/22 (36%)
		leucine-rich repeat	159..182	CDD:275380	6/22 (27%)
		LRR_8	182..237	CDD:290566	19/55 (35%)
		leucine-rich repeat	183..206	CDD:275380	8/22 (36%)
		leucine-rich repeat	207..230	CDD:275380	9/23 (39%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		leucine-rich repeat	255..302	CDD:275380	12/47 (26%)
		LRR_8	278..334	CDD:290566	16/55 (29%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		LRR_8	326..385	CDD:290566	23/84 (27%)
		leucine-rich repeat	327..348	CDD:275380	8/21 (38%)
		leucine-rich repeat	351..374	CDD:275380	6/47 (13%)
		IG_like	445..526	CDD:214653
		Ig	456..526	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1280
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910