DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment caps and Flrt1

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001102630.1	Gene:	Flrt1 / 499308	RGDID:	1565152	Length:	674	Species:	Rattus norvegicus

Alignment Length:	627	Identity:	153/627 - (24%)
Similarity:	222/627 - (35%)	Gaps:	178/627 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LCLCLCLVLATLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRLVIKNNK---- 83
            |.||..|: |.|...:....||:.|.||:.  .:.|.:..|..:|..:......|.::||:
  Rat    35 LFLCYGLI-AFLTEVIDSTTCPSVCRCDNG--FIYCNDRGLTSIPSDIPDDATTLYLQNNQINNA 96

  Fly    84 -----LKTIDSSMQFY--------------AQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHN 129
                 |||.......|              ..|..|.|..|::.||...|.|....|::||||.|
  Rat    97 GIPQDLKTKVKVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDN 161

  Fly   130 KIGQVS--NKTFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDN 192
            .:..||  ...|.....:.:|.|..|.::.:.  :..|.. |.||.|..||||.|..||..||::
  Rat   162 SVSTVSIEEDAFADSKQLKLLFLSRNHLSSIP--SGLPHT-LEELRLDDNRISTIPLHAFKGLNS 223

  Fly   193 LRVLYLDDNTLTTVP-GELTFQALHSLAELYLGTNSF----MTIPGGAFQDLKGLTRLDLRGAGL 252
            ||.|.||.|.|.... .:.||..|.:|.||.|..||.    :.:|....|      :|.|:...:
  Rat   224 LRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQ------KLYLQDNAI 282

  Fly   253 HNISGDALKGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSG-----LR 312
            .:|..:.|..:..|..||||:|.|..:|...|..||.|.||.:..|.:       |.|     ||
  Rat   283 SHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPW-------FCGCNLMWLR 340

  Fly   313 E----------LRHLELTGAQRLRRV-------------ESGAFSGNTNLEHLNLSSNKQLNELS 354
            :          :|.|...|.:::|.:             |:|:.....|......:||.
  Rat   341 DWVKARAAVVNVRGLMCQGPEKVRGMAIKDITSEMDECFEAGSQGSAANAAAKTTASNH------ 399

  Fly   355 SIALGGLPHLSTVVLKANQL------SSLDEGLVPWADLQTLDLSENPFECDC------------ 401
              |....|..|...|||.:.      |::|..:......:||.:...|...|.
  Rat   400 --ASATTPQGSLFTLKAKRPGLRLPDSNIDYPMATGDGAKTLVIQVKPLTADSIRITWKAMLPAS 462

  Fly   402 --RLLWLR---------------------HLLVSRNASGQYAPVIC------------------- 424
              ||.|||                     :||.:......|  :||
  Rat   463 SFRLSWLRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTY--IICMVTMETGNTYVADETPVCA 525

  Fly   425 ------AY-PTALRDL-----PLAHLAEPLLGCAHGAASKQAIIGILVVACAALITTLALVLYTC 477
                  :| ||...:.     |:|.|  ||.|...||           ||...|...|..:.:..
  Rat   526 KAETADSYGPTTTLNQEQNAGPMAGL--PLAGIIGGA-----------VALVFLFLVLGAICWYV 577

  Fly   478 RHRIREML---KGHSALGRKEREYQK--TFSDEEYMSRPPPG 514
             ||..|:|   :.::...||:.:|.:  |..|...:....||
  Rat   578 -HRAGELLTRERVYNRGSRKKDDYMESGTKKDNSILEIRGPG 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	7/43 (16%)
		LRR_8	96..155	CDD:290566	20/60 (33%)
		leucine-rich repeat	97..120	CDD:275380	8/22 (36%)
		leucine-rich repeat	121..144	CDD:275380	9/24 (38%)
		LRR_8	143..201	CDD:290566	22/57 (39%)
		leucine-rich repeat	145..168	CDD:275380	4/22 (18%)
		LRR_RI	147..397	CDD:238064	77/288 (27%)
		leucine-rich repeat	169..192	CDD:275380	13/22 (59%)
		leucine-rich repeat	193..217	CDD:275380	10/24 (42%)
		LRR_8	217..276	CDD:290566	18/62 (29%)
		leucine-rich repeat	218..241	CDD:275380	8/26 (31%)
		leucine-rich repeat	242..265	CDD:275380	4/22 (18%)
		LRR_8	265..321	CDD:290566	21/70 (30%)
		leucine-rich repeat	266..289	CDD:275380	10/22 (45%)
		leucine-rich repeat	290..313	CDD:275380	7/27 (26%)
		LRR_8	312..374	CDD:290566	16/84 (19%)
		leucine-rich repeat	314..335	CDD:275380	6/33 (18%)
		leucine-rich repeat	339..363	CDD:275380	3/23 (13%)
		LRRCT	395..445	CDD:214507	20/115 (17%)
Flrt1	NP_001102630.1	PRK15370	<58..>329	CDD:185268	83/281 (30%)
		leucine-rich repeat	108..128	CDD:275380	1/19 (5%)
		leucine-rich repeat	129..152	CDD:275380	8/22 (36%)
		leucine-rich repeat	153..178	CDD:275380	9/24 (38%)
		leucine-rich repeat	179..199	CDD:275380	4/21 (19%)
		leucine-rich repeat	200..223	CDD:275380	13/22 (59%)
		leucine-rich repeat	224..249	CDD:275380	10/24 (42%)
		leucine-rich repeat	250..271	CDD:275380	7/20 (35%)
		leucine-rich repeat	272..295	CDD:275380	5/28 (18%)
		leucine-rich repeat	296..319	CDD:275380	10/22 (45%)
		PCC	300..>386	CDD:188093	23/92 (25%)
		FN3	441..505	CDD:214495	10/65 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	3	2.870