DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment caps and trn

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster

Alignment Length:	762	Identity:	391/762 - (51%)
Similarity:	490/762 - (64%)	Gaps:	83/762 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VLATLPV--ALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRLVIKNNKLKTIDSSMQ 92
            :||::.|  |.||||||.||:|||:||:|.||||.||||||||||:|||||||:||:||||||:|
  Fly    15 ILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDSSIQ 79

  Fly    93 FYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLIAE 157
            |||:|||||||.|.::|||:|:|||..||||:||:||||||:|||||:|||.::|||||||.|:|
  Fly    80 FYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISE 144

  Fly   158 LEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHSLAELY 222
            |...||:|::|:.|||||:|||.::||.|.|||..||:||||||.|||||..:.|||:.|||||:
  Fly   145 LHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELF 209

  Fly   223 LGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLSDNRLPAIPTAAFQRL 287
            ||.|:..:|...|||||||||||:|:||.|.|||.|:..||..||.||||||||..||:....:|
  Fly   210 LGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKL 274

  Fly   288 GRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSNKQLNE 352
            .|||||::|||||||||.|||.||::|:.||:.||.||:||.:||||.|.|||:|||||||.|.|
  Fly   275 VRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLE 339

  Fly   353 LSSIALGGLPHLSTVVLKANQLSSLDEGLVPWADLQTLDLSENPFECDCRLLWLRHLLVSRNAS- 416
            :...||.||..|..||||||.|:||.|||.||.|||||||||||..||||::||.:|||::|||
  Fly   340 VQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSCDCRVMWLHNLLVAKNASQ 404

  Fly   417 GQYAPVICAYPTALRDLPLAHLAEPLLGCAHGAASKQAIIGILVVACAALITTLALVLYTCRHRI 481
            ...:.::|.:|..||...|.||...::||.|....|||:||.|:|..||.||.||||||.|||:|
  Fly   405 DDVSELLCEFPERLRGESLRHLNPAMMGCTHADPRKQALIGALLVGSAATITALALVLYRCRHKI 469

  Fly   482 REMLK----GHSALGRKEREYQKTFSDEEYMSRPP--PGGGGVHP------AAGGYPYIAGNSRM 534
            ||.:|    |:||||||||||||||.||:||||..  |...|:|.      .|..:|....:..|
  Fly   470 RETIKGGLWGNSALGRKEREYQKTFCDEDYMSRHQHHPCSLGIHSTFPNTYTAPHHPGATHHYGM 534

  Fly   535 IPVTELXLEAPPPPQLRGRGGGGGASTASGAVQQLQVPSAVDQASNSFAQLSHIHYMTNNGQQQQ 599
            .|:....|.|..|.|               ..|||.||:|        ..:|......|.....|
  Fly   535 CPMPVNDLGAIDPQQ---------------KFQQLVVPTA--------TMISEKKLNNNKALVSQ 576

  Fly   600 AQQQQSTSKMHH----------SQQDMRLLACNGGKPLNATSLPRHRPPVVQESTLSHYSQPLAN 654
            .....|.|.:.|          .||:.:|......:.|:||:       .|.:|..|:...|:.:
  Fly   577 GAIDDSASFVLHMKSATMGRDVHQQNPQLNHYTKPQFLSATA-------TVGDSCYSYADVPMVH 634

  Fly   655 G----------IRLTQDHFNHNQNQSHNQHYGGVYAKPCDAMSEPGYIHNNSHYSLPLDHDLPPS 709
            |          :||||:||  .|.:.::|..|       ..:.:..||::|:|||:||: .|..|
  Fly   635 GAPLGGPNQPQLRLTQEHF--KQRELYDQEMG-------SEILDHNYIYSNTHYSMPLE-QLGRS 689

  Fly   710 PTPTPP--PPALPLRNGVGMALIHGNTTGRRSFNNNNNVSTLSNNNH 754
            .|||||  |||||||||:..      |||||||...:.......||:
  Fly   690 KTPTPPPMPPALPLRNGLCA------TTGRRSFQQKSASQKQQQNNN 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	17/20 (85%)
		LRR_8	96..155	CDD:290566	42/58 (72%)
		leucine-rich repeat	97..120	CDD:275380	15/22 (68%)
		leucine-rich repeat	121..144	CDD:275380	18/22 (82%)
		LRR_8	143..201	CDD:290566	35/57 (61%)
		leucine-rich repeat	145..168	CDD:275380	13/22 (59%)
		LRR_RI	147..397	CDD:238064	161/249 (65%)
		leucine-rich repeat	169..192	CDD:275380	14/22 (64%)
		leucine-rich repeat	193..217	CDD:275380	16/23 (70%)
		LRR_8	217..276	CDD:290566	38/58 (66%)
		leucine-rich repeat	218..241	CDD:275380	13/22 (59%)
		leucine-rich repeat	242..265	CDD:275380	14/22 (64%)
		LRR_8	265..321	CDD:290566	35/55 (64%)
		leucine-rich repeat	266..289	CDD:275380	13/22 (59%)
		leucine-rich repeat	290..313	CDD:275380	18/22 (82%)
		LRR_8	312..374	CDD:290566	37/61 (61%)
		leucine-rich repeat	314..335	CDD:275380	12/20 (60%)
		leucine-rich repeat	339..363	CDD:275380	15/23 (65%)
		LRRCT	395..445	CDD:214507	21/50 (42%)
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	14/17 (82%)
		LRR_8	83..142	CDD:290566	42/58 (72%)
		leucine-rich repeat	84..107	CDD:275380	15/22 (68%)
		leucine-rich repeat	108..131	CDD:275380	18/22 (82%)
		LRR_RI	129..421	CDD:238064	180/291 (62%)
		LRR_8	132..190	CDD:290566	36/57 (63%)
		leucine-rich repeat	132..155	CDD:275380	13/22 (59%)
		leucine-rich repeat	156..179	CDD:275380	14/22 (64%)
		leucine-rich repeat	180..204	CDD:275380	16/23 (70%)
		LRR_8	203..263	CDD:290566	38/59 (64%)
		leucine-rich repeat	205..228	CDD:275380	13/22 (59%)
		leucine-rich repeat	229..252	CDD:275380	14/22 (64%)
		LRR_8	252..308	CDD:290566	35/55 (64%)
		leucine-rich repeat	253..276	CDD:275380	13/22 (59%)
		leucine-rich repeat	277..300	CDD:275380	18/22 (82%)
		leucine-rich repeat	301..322	CDD:275380	12/20 (60%)
		LRR_8	325..384	CDD:290566	41/58 (71%)
		leucine-rich repeat	326..350	CDD:275380	15/23 (65%)
		leucine-rich repeat	351..373	CDD:275380	15/21 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472903
Domainoid	1	1.000	123	1.000	Domainoid score	I11061
eggNOG	1	0.900	-	-		E33208_3BG7P
Homologene	1	1.000	-	-		H21274
Inparanoid	1	1.050	157	1.000	Inparanoid score	I4248
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D187891at33208
OrthoFinder	1	1.000	-	-		FOG0007624
OrthoInspector	1	1.000	-	-		mtm6470
orthoMCL	1	0.900	-	-		OOG6_103993
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1280
	11	10.700