DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and CG6749

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	478	Identity:	115/478 - (24%)
Similarity:	194/478 - (40%)	Gaps:	121/478 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 APHLGQAFSLCLCLCLCLVLATLPVAL---GLANCPN-------GCECDDDTLMVNCGEGTLDVL 66
            |.||.....|.|       ....|:.:   |.:..||       ||             |.:|:.
  Fly    76 ADHLANLLDLDL-------TGAAPINVHTNGFSILPNLRQLNLSGC-------------GLVDIR 120

  Fly    67 --PIALNPAIQRLVIKNNKLKTIDSSMQFYA---QLTFLDLSFN-----DMLTIP---------- 111
              ..|...|:||:...:|:::.:|  ..|:.   :|.:.:.|.|     |:..:|
  Fly   121 GNHFAPESALQRIDFSHNQMELLD--RDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHN 183

  Fly   112 ---ERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELN 173
               ..:|....:||||.|:.|::.|:....|.||..:..|.|.||.::.:...||.|:.:|.:||
  Fly   184 RLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLN 248

  Fly   174 LGQNRISHIDPHALDGLDN----------------------------LRVLYLDDNTLTTV-PGE 209
            |.||.:..:.|:....:.|                            |::|.:..|::.:: |..
  Fly   249 LSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAH 313

  Fly   210 LTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKG--LVSLRFLDLS 272
              |..|.||.:|||..|:.:.|....|..|..|..|||....|..:......|  |..:|.|:|:
  Fly   314 --FVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLN 376

  Fly   273 DNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNT 337
            .||:..:...||..|..||.|.:|.|:.:.:....|:.:|.|:.|.|               |:.
  Fly   377 GNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHL---------------GHN 426

  Fly   338 NLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWADLQTLDLSENPFECDCR 402
            .||.:||.   .|..|||:        ..:::..|:|:.|.:..|.:.:|:.:.:..||::|.|
  Fly   427 LLEEINLD---VLESLSSV--------QEILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQCPC- 479

  Fly   403 LLWLRHLLVSRNA------SGQY 419
            .:.|:|.|.:|:.      :|.|
  Fly   480 FVKLQHWLATRDVVYLRDNTGYY 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	5/23 (22%)
		LRR_8	96..155	CDD:290566	20/76 (26%)
		leucine-rich repeat	97..120	CDD:275380	6/40 (15%)
		leucine-rich repeat	121..144	CDD:275380	10/22 (45%)
		LRR_8	143..201	CDD:290566	17/85 (20%)
		leucine-rich repeat	145..168	CDD:275380	7/22 (32%)
		LRR_RI	147..397	CDD:238064	70/280 (25%)
		leucine-rich repeat	169..192	CDD:275380	7/22 (32%)
		leucine-rich repeat	193..217	CDD:275380	6/24 (25%)
		LRR_8	217..276	CDD:290566	20/60 (33%)
		leucine-rich repeat	218..241	CDD:275380	8/22 (36%)
		leucine-rich repeat	242..265	CDD:275380	7/24 (29%)
		LRR_8	265..321	CDD:290566	18/55 (33%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		LRR_8	312..374	CDD:290566	14/61 (23%)
		leucine-rich repeat	314..335	CDD:275380	3/20 (15%)
		leucine-rich repeat	339..363	CDD:275380	8/23 (35%)
		LRRCT	395..445	CDD:214507	10/31 (32%)
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	42/167 (25%)
		LRR_8	104..164	CDD:290566	16/74 (22%)
		leucine-rich repeat	106..129	CDD:275380	5/35 (14%)
		leucine-rich repeat	130..153	CDD:275380	5/24 (21%)
		leucine-rich repeat	154..195	CDD:275380	6/40 (15%)
		LRR_RI	194..455	CDD:238064	76/288 (26%)
		LRR_8	194..254	CDD:290566	23/59 (39%)
		leucine-rich repeat	196..219	CDD:275380	10/22 (45%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..267	CDD:275380	7/22 (32%)
		LRR_8	271..330	CDD:290566	12/60 (20%)
		leucine-rich repeat	272..295	CDD:275380	0/22 (0%)
		leucine-rich repeat	296..319	CDD:275380	6/24 (25%)
		LRR_8	319..380	CDD:290566	20/60 (33%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	7/24 (29%)
		LRR_8	368..428	CDD:290566	19/74 (26%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	6/22 (27%)
		leucine-rich repeat	418..441	CDD:275380	10/40 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472910
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940