DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment caps and ltl

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001261524.1	Gene:	ltl / 38845	FlyBaseID:	FBgn0268063	Length:	817	Species:	Drosophila melanogaster

Alignment Length:	847	Identity:	170/847 - (20%)
Similarity:	289/847 - (34%)	Gaps:	254/847 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LANCPNGCECDDDTLMVNCGEGTLDVLPIA----LNPAIQRLVIKNNKLKTI-DSSMQFYAQLTF 99
            |||..|.    |..:.:......||.|.:.    :|..:.:|.::.|.||:: :...:..:.:|:
  Fly    53 LANKLNA----DTNIDLKITHSQLDDLEMRSFTDMNFNLYKLRMQWNSLKSLPEVPFRGLSNVTY 113

  Fly   100 LDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLIAELEYRTFS 164
            |.:..||:..||:.:.::...|..|.:...||..|..:.|.|:..::.|.|..|:|..|:..:|.
  Fly   114 LSIGDNDLDEIPKHALSHMPSLLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFP 178

  Fly   165 PMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGEL------------------- 210
            .  .|..|:||:|::..:: .:|..|.||..|:::.|.:|::..||
  Fly   179 K--SLLILHLGRNQLESLN-GSLHDLHNLESLFINANNITSLDDELPDGGQLRLLMAHNNRLERL 240

  Fly   211 --TFQALHSLAELYLGTN---SFMTIPGGAF----------------QD---------------- 238
              ....:|||..:::..|   ||..:...|.                ||
  Fly   241 PANMAGMHSLETVHIHCNQLRSFDRVLRNAVNLSEVMADNNELEYLAQDEFASCSKVETLQMGCN 305

  Fly   239 -LKGLTR-----LDLRGAG-----LHNISGDALKGLVSLRFLDLSDNRLPAI--PTAAFQRLGRL 290
             :|.|..     |.|:.|.     :...|...|.||.||:.|.||.||:..:  .....|.| .|
  Fly   306 HIKSLNSSLLPILKLKNANFSFNDIEEFSMAELHGLRSLKTLQLSSNRIQRLLPDPRGVQEL-ML 369

  Fly   291 EQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSNKQLNELSS 355
            ..|::..|..:.: :||.:||..||.|.|.| .||..::.|.|.|...|:.|:|:.| ||.||..
  Fly   370 VNLDLDNNRIDSL-NGALAGLGNLRILNLAG-NRLEHLQVGDFDGMIRLDILDLTGN-QLAELKP 431

  Fly   356 IAL-----------------------GGLPHLSTVVLKANQLSSLDEGLVPWADLQT-------- 389
            :.:                       .|||.|....|..||:|::...||.....:.
  Fly   432 LEMTLLPSLKILKVAYNNITKLEQDFKGLPVLCQANLTNNQISTISSELVTNTRCKNHNVPGKLE 496

  Fly   390 LDLSENPFECD------CRLLWLRHLLV-SRNASGQYAPVICA---------YPTALRDLPLA-- 436
            :.|.:||..||      |||:.::...: .|:...:....:|.         .|..:.:|.|.
  Fly   497 IHLDDNPIMCDVGLNELCRLMAVQEARIRGRSQCFENDQEVCTVLPMLYNVNLPIMVTNLKLTGR 561

  Fly   437 HLAEPLLGCAHGAASKQAIIGILVVACAALITTLALVLYTCRHRIREMLKGHSALGRKEREYQKT 501
            .:.:|::         :.|:..|:.|...|:..|...|
  Fly   562 EVPKPMV---------RVIVPSLIKANNELLPPLIATL--------------------------- 590

  Fly   502 FSDEEYMSRPPPGGGGVHPAAGGYPYIAGNSRMIPVTELXLEAPPPPQLRGRGGGGGASTASGAV 566
                                  |.|.:.....:.||    :...|||.|.       |:|.....
  Fly   591 ----------------------GNPVLISTDLVNPV----ISPLPPPLLL-------ATTTPPPP 622

  Fly   567 QQLQVPSAVDQASNSFAQLSHIHYMTNNGQQQQAQQQQSTSKMHHSQQDMRLLACNGGKPLNATS 631
            ..|.|.|.|::..::.|.....:|..............:|::.......:.::....  |...|:
  Fly   623 LPLPVESEVEKNESTTANPVPTNYTQETTTTTSTTTTTTTTETSSQVAPIEIITTTA--PTTTTT 685

  Fly   632 -----LPRHRPPVVQE--------STLSHYS-------QPLANGIRLTQDHFNHNQNQSHNQH-- 674
                 .|....||:.|        :|::..:       .||...:...::.....:.:....|
  Fly   686 STTTPKPNETLPVIVELQDPNPPDTTVNQTALVPPVVLDPLQQDLERERERERERELERDLDHEA 750

  Fly   675 -----YGGVYAKP--------CDAMSEP-----------GYIHNNS-HYSLPLDHDLPPSPTPTP 714
                 |..|...|        .||::.|           ..:|:|| |...|  |.......|..
  Fly   751 VAKTEYETVEYIPNLVQPPVGSDALTPPPSKANALEEDSESVHSNSVHAEYP--HAAQSLQIPEE 813

  Fly   715 PP 716
            ||
  Fly   814 PP 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	4/21 (19%)
		LRR_8	96..155	CDD:290566	16/58 (28%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR_8	143..201	CDD:290566	16/57 (28%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		LRR_RI	147..397	CDD:238064	84/349 (24%)
		leucine-rich repeat	169..192	CDD:275380	7/22 (32%)
		leucine-rich repeat	193..217	CDD:275380	6/44 (14%)
		LRR_8	217..276	CDD:290566	23/104 (22%)
		leucine-rich repeat	218..241	CDD:275380	7/58 (12%)
		leucine-rich repeat	242..265	CDD:275380	8/32 (25%)
		LRR_8	265..321	CDD:290566	20/57 (35%)
		leucine-rich repeat	266..289	CDD:275380	8/24 (33%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		LRR_8	312..374	CDD:290566	24/84 (29%)
		leucine-rich repeat	314..335	CDD:275380	9/20 (45%)
		leucine-rich repeat	339..363	CDD:275380	10/46 (22%)
		LRRCT	395..445	CDD:214507	13/67 (19%)
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380	4/20 (20%)
		LRR_8	86..145	CDD:290566	12/58 (21%)
		leucine-rich repeat	87..110	CDD:275380	4/22 (18%)
		leucine-rich repeat	111..134	CDD:275380	6/22 (27%)
		leucine-rich repeat	135..158	CDD:275380	7/22 (32%)
		LRR_8	158..214	CDD:290566	17/58 (29%)
		leucine-rich repeat	159..180	CDD:275380	6/22 (27%)
		leucine-rich repeat	181..203	CDD:275380	7/22 (32%)
		leucine-rich repeat	204..226	CDD:275380	6/21 (29%)
		LRR_RI	226..451	CDD:238064	52/228 (23%)
		leucine-rich repeat	227..249	CDD:275380	0/21 (0%)
		leucine-rich repeat	250..272	CDD:275380	5/21 (24%)
		leucine-rich repeat	273..296	CDD:275380	2/22 (9%)
		leucine-rich repeat	297..315	CDD:275380	2/17 (12%)
		LRR_8	319..402	CDD:290566	27/85 (32%)
		leucine-rich repeat	320..335	CDD:275378	2/14 (14%)
		leucine-rich repeat	344..366	CDD:275380	6/21 (29%)
		leucine-rich repeat	367..391	CDD:275380	8/25 (32%)
		LRR_8	369..426	CDD:290566	21/59 (36%)
		leucine-rich repeat	392..415	CDD:275380	10/23 (43%)
		leucine-rich repeat	416..439	CDD:275380	8/23 (35%)
		LRR_8	438..>479	CDD:290566	8/40 (20%)
		leucine-rich repeat	440..462	CDD:275380	2/21 (10%)
		leucine-rich repeat	463..483	CDD:275380	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453595
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930