DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment caps and NRROS

DIOPT Version :9

Sequence 1:NP_001303391.1 Gene:caps / 39493 FlyBaseID:FBgn0023095 Length:811 Species:Drosophila melanogaster
Sequence 2:NP_940967.1 Gene:NRROS / 375387 HGNCID:24613 Length:692 Species:Homo sapiens


Alignment Length:491 Identity:129/491 - (26%)
Similarity:188/491 - (38%) Gaps:106/491 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 LCLCLCLVLATLPVA----LGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRLVIKNNK 83
            |.|.|||....|.|.    .|.|...:...|.......:|...:|..:|.:|.|..:.|.:..|.
Human     4 LPLWLCLGFHFLTVGWRNRSGTATAASQGVCKLVGGAADCRGQSLASVPSSLPPHARMLTLDANP 68

  Fly    84 LKTI-DSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISV 147
            |||: :.|:|.|..|..|.|....:..|...:|.....|:.|.|..|.:.:...:|...|     
Human    69 LKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEETAAAL----- 128

  Fly   148 LNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTF 212
                                                 |||.|   ||.|.|..|.||.....|..
Human   129 -------------------------------------HALPG---LRRLDLSGNALTEDMAALML 153

  Fly   213 QALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLSDNRLP 277
            |.|.||..:.|..|:.|.:....|:.|:.|..|||:...:..|.|.|..||..||.|:|:.|.||
Human   154 QNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLP 218

  Fly   278 AIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQ-----------RLRRVESG 331
            .|....   |.||..||:..|..|...:.......||..|:|:..|           :||.:   
Human   219 CIVDFG---LTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTL--- 277

  Fly   332 AFSGNTNL----EHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWADLQTLDL 392
             ...:.|:    :..|.||.:::.....:..|.:.:::||.| ..:.||.|     .|||:.||:
Human   278 -LLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSL-WEEFSSSD-----LADLRFLDM 335

  Fly   393 SENPFEC--D---CRLLWLRHLLVSRNA-----SGQYAPVICAYPTALRDLPLA-------HLAE 440
            |:|.|:.  |   .::..|.||.:.:|.     ..::.|     |.||.:|.|:       |||.
Human   336 SQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEP-----PGALTELDLSHNQLSELHLAP 395

  Fly   441 PLLGCAHGA----ASKQAIIGIL--VVACAALITTL 470
            .|..|....    .|...::|:.  :.|.|..||||
Human   396 GLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTL 431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
capsNP_001303391.1 leucine-rich repeat 75..96 CDD:275380 8/21 (38%)
LRR_8 96..155 CDD:290566 11/58 (19%)
leucine-rich repeat 97..120 CDD:275380 5/22 (23%)
leucine-rich repeat 121..144 CDD:275380 6/22 (27%)
LRR_8 143..201 CDD:290566 8/57 (14%)
leucine-rich repeat 145..168 CDD:275380 0/22 (0%)
LRR_RI 147..397 CDD:238064 70/264 (27%)
leucine-rich repeat 169..192 CDD:275380 4/22 (18%)
leucine-rich repeat 193..217 CDD:275380 10/23 (43%)
LRR_8 217..276 CDD:290566 21/58 (36%)
leucine-rich repeat 218..241 CDD:275380 6/22 (27%)
leucine-rich repeat 242..265 CDD:275380 9/22 (41%)
LRR_8 265..321 CDD:290566 19/55 (35%)
leucine-rich repeat 266..289 CDD:275380 9/22 (41%)
leucine-rich repeat 290..313 CDD:275380 5/22 (23%)
LRR_8 312..374 CDD:290566 15/76 (20%)
leucine-rich repeat 314..335 CDD:275380 6/31 (19%)
leucine-rich repeat 339..363 CDD:275380 4/27 (15%)
LRRCT 395..445 CDD:214507 17/66 (26%)
NRROSNP_940967.1 leucine-rich repeat 42..61 CDD:275380 5/18 (28%)
LRR 1. /evidence=ECO:0000255 58..79 6/20 (30%)
leucine-rich repeat 62..82 CDD:275380 8/19 (42%)
LRR_RI 76..>285 CDD:238064 67/260 (26%)
LRR_8 81..144 CDD:290566 20/107 (19%)
LRR 2. /evidence=ECO:0000255 82..103 5/20 (25%)
leucine-rich repeat 83..106 CDD:275380 5/22 (23%)
LRR 3. /evidence=ECO:0000255 106..127 5/20 (25%)
leucine-rich repeat 107..133 CDD:275380 9/67 (13%)
LRR 4. /evidence=ECO:0000255 133..155 9/24 (38%)
leucine-rich repeat 134..158 CDD:275380 10/23 (43%)
LRR_8 157..217 CDD:290566 21/59 (36%)
LRR 5. /evidence=ECO:0000255 158..179 6/20 (30%)
leucine-rich repeat 159..182 CDD:275380 6/22 (27%)
LRR 6. /evidence=ECO:0000255 182..203 7/20 (35%)
leucine-rich repeat 183..206 CDD:275380 9/22 (41%)
LRR 7. /evidence=ECO:0000255 206..227 9/23 (39%)
leucine-rich repeat 207..227 CDD:275380 9/22 (41%)
leucine-rich repeat 228..251 CDD:275380 5/22 (23%)
LRR 8. /evidence=ECO:0000255 228..239 4/10 (40%)
LRR 9. /evidence=ECO:0000255 251..272 5/20 (25%)
leucine-rich repeat 252..273 CDD:275380 4/20 (20%)
LRR 10. /evidence=ECO:0000255 273..294 4/24 (17%)
LRR 11. /evidence=ECO:0000255 329..350 8/20 (40%)
LRR_8 330..388 CDD:290566 17/62 (27%)
leucine-rich repeat 330..353 CDD:275380 7/22 (32%)
LRR 12. /evidence=ECO:0000255 353..374 4/20 (20%)
leucine-rich repeat 354..377 CDD:275380 6/27 (22%)
LRR_RI 357..594 CDD:238064 21/80 (26%)
LRR 13. /evidence=ECO:0000255 377..398 7/20 (35%)
LRR_8 378..438 CDD:290566 16/54 (30%)
leucine-rich repeat 378..403 CDD:275380 8/24 (33%)
LRR 14. /evidence=ECO:0000255 403..424 2/20 (10%)
leucine-rich repeat 404..427 CDD:275380 4/22 (18%)
LRR 15. /evidence=ECO:0000255 427..447 4/5 (80%)
leucine-rich repeat 428..463 CDD:275380 4/4 (100%)
LRR 16. /evidence=ECO:0000255 463..484
leucine-rich repeat 464..486 CDD:275380
LRR 17. /evidence=ECO:0000255 486..507
leucine-rich repeat 487..512 CDD:275380
LRR 18. /evidence=ECO:0000255 512..534
LRR_8 513..570 CDD:290566
leucine-rich repeat 513..537 CDD:275380
LRR 19. /evidence=ECO:0000255 537..558
leucine-rich repeat 538..559 CDD:275380
LRR 20. /evidence=ECO:0000255 559..580
LRR 21. /evidence=ECO:0000255 585..594
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45617
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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