DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and 18w

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster

Alignment Length:	573	Identity:	139/573 - (24%)
Similarity:	211/573 - (36%)	Gaps:	175/573 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 APHLGQAFSLCLCLCLCLVLATLPVALGLANCPNGCECDDDTLMVNCGEGTLDV-------LPIA 69
            |..||.:..||             ....|:|. ||.......|.      ||||       ||.|
  Fly   184 AEFLGFSEKLC-------------AGSALSNA-NGAVSGGSELQ------TLDVSFNELRSLPDA 228

  Fly    70 LNPA----IQRLVIKNNKLKTI-DSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHN 129
            ...:    :|.|.:::|.:.|: .:::...:.|..|::|:|.::::|..:||.:.:|:||||..|
  Fly   229 WGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGN 293

  Fly   130 KIGQ--------------------------VSNKTFLGLSTISVLNLRGNLIAELEYRTFSPMVK 168
            .:.:                          |.|.||.||..:.||||..|.:..:..:||..:..
  Fly   294 DLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYF 358

  Fly   169 LAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHSLAELYLGTNSFMTIPG 233
            |..|::..|.|.||:..|...|.||..|.|.:|.|.|:...: |..|:.|.:|.|..|....:..
  Fly   359 LQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRI-FNGLYVLTKLTLNNNLVSIVES 422

  Fly   234 GAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQN 298
            .||::...|..|||....|..:. :|::.|..|:.|||.:|::.......|:.|.:|..|.:..|
  Fly   423 QAFRNCSDLKELDLSSNQLTEVP-EAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDN 486

  Fly   299 DFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPH 363
            ....|:.|.|..|..|..|.| ...|::.:|.|||..||.:|.:.|..| .|.:::.| ...|..
  Fly   487 RIGNITVGMFQDLPRLSVLNL-AKNRIQSIERGAFDKNTEIEAIRLDKN-FLTDINGI-FATLAS 548

  Fly   364 LSTVVLKANQLSSLDEGLVP----WADLQ--------------------TLDLSE---------- 394
            |..:.|..|.|...|...:|    |.|:.                    |||.|.
  Fly   549 LLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMS 613

  Fly   395 ----------------------------------------------------------------- 394

  Fly   614 VPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGG 678

  Fly   395 NPFECDCRLLWLRHL--LVSRNASGQYAPVI------CAYPTALRDLPLAHLA 439
            |||||||.:.||:.:  |.:|    |:..|:      |..|.: |..||..||
  Fly   679 NPFECDCSMEWLQRINNLTTR----QHPHVVDLGNIECLMPHS-RSAPLRPLA 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	4/21 (19%)
		LRR_8	96..155	CDD:290566	24/84 (29%)
		leucine-rich repeat	97..120	CDD:275380	7/22 (32%)
		leucine-rich repeat	121..144	CDD:275380	12/48 (25%)
		LRR_8	143..201	CDD:290566	19/57 (33%)
		leucine-rich repeat	145..168	CDD:275380	7/22 (32%)
		LRR_RI	147..397	CDD:238064	80/348 (23%)
		leucine-rich repeat	169..192	CDD:275380	8/22 (36%)
		leucine-rich repeat	193..217	CDD:275380	8/23 (35%)
		LRR_8	217..276	CDD:290566	18/58 (31%)
		leucine-rich repeat	218..241	CDD:275380	6/22 (27%)
		leucine-rich repeat	242..265	CDD:275380	7/22 (32%)
		LRR_8	265..321	CDD:290566	17/55 (31%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		LRR_8	312..374	CDD:290566	19/61 (31%)
		leucine-rich repeat	314..335	CDD:275380	8/20 (40%)
		leucine-rich repeat	339..363	CDD:275380	6/23 (26%)
		LRRCT	395..445	CDD:214507	20/53 (38%)
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380	6/29 (21%)
		LRR_RI	210..464	CDD:238064	73/261 (28%)
		leucine-rich repeat	212..236	CDD:275380	8/29 (28%)
		LRR_8	235..295	CDD:290566	17/59 (29%)
		leucine-rich repeat	237..260	CDD:275380	4/22 (18%)
		leucine-rich repeat	261..284	CDD:275380	7/22 (32%)
		LRR_8	283..345	CDD:290566	17/61 (28%)
		leucine-rich repeat	285..308	CDD:275380	6/22 (27%)
		leucine-rich repeat	309..334	CDD:275380	6/24 (25%)
		LRR_8	334..393	CDD:290566	20/58 (34%)
		leucine-rich repeat	335..358	CDD:275380	7/22 (32%)
		leucine-rich repeat	359..382	CDD:275380	8/22 (36%)
		LRR_8	382..441	CDD:290566	19/59 (32%)
		leucine-rich repeat	383..406	CDD:275380	8/23 (35%)
		leucine-rich repeat	407..430	CDD:275380	6/22 (27%)
		LRR_8	431..488	CDD:290566	17/57 (30%)
		leucine-rich repeat	431..451	CDD:275380	6/20 (30%)
		leucine-rich repeat	454..477	CDD:275380	7/22 (32%)
		LRR_8	477..559	CDD:290566	26/84 (31%)
		leucine-rich repeat	478..499	CDD:275380	6/20 (30%)
		leucine-rich repeat	502..525	CDD:275380	9/23 (39%)
		leucine-rich repeat	526..548	CDD:275380	6/23 (26%)
		leucine-rich repeat	590..617	CDD:275380	4/26 (15%)
		leucine-rich repeat	618..641	CDD:275380	0/22 (0%)
		leucine-rich repeat	642..689	CDD:275380	7/46 (15%)
		LRRCT	679..736	CDD:214507	20/53 (38%)
		leucine-rich repeat	775..796	CDD:275380
		LRR_8	797..852	CDD:290566
		leucine-rich repeat	797..817	CDD:275380
		leucine-rich repeat	818..841	CDD:275380
		LRR_8	841..900	CDD:290566
		leucine-rich repeat	842..865	CDD:275380
		LRR_4	866..907	CDD:289563
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..911	CDD:275380
		TIR	1045..1183	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453542
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940