DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment caps and Tril

DIOPT Version :9

Sequence 1:NP_001303391.1 Gene:caps / 39493 FlyBaseID:FBgn0023095 Length:811 Species:Drosophila melanogaster
Sequence 2:NP_001029182.1 Gene:Tril / 362364 RGDID:1310827 Length:811 Species:Rattus norvegicus


Alignment Length:725 Identity:175/725 - (24%)
Similarity:261/725 - (36%) Gaps:211/725 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 FSLCLCLCLCLVLATLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRLV---IK 80
            |.|.:|.|    ||..|.|..:  ||..|:|.....::....|...|...:..|:.|.::   :.
  Rat     9 FWLVVCGC----LAFPPRAESV--CPERCDCQHPQHLLCTNRGLRAVPKTSSLPSPQDVLTYSLG 67

  Fly    81 NNKLKTIDSSMQFY--AQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDH--------------- 128
            .|.:..| ::..|:  .||..|||.:|.:.::..::|...::|:||:|.:               
  Rat    68 GNFITNI-TAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLR 131

  Fly   129 ---------NKIGQVSNKTFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDP 184
                     |:||::|..:|.||.::..|.|.||::..|....|:|:..|..|:|..|||..:..
  Rat   132 KLRILYANGNEIGRLSRGSFEGLESLVKLRLDGNVLGALPDAVFAPLGNLLYLHLEANRIRFLGK 196

  Fly   185 HALDGLDNLRVLYLDDNTL-TTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLR 248
            :|...|..||.|.|..|.| .::....||..|.||:.|.|..||...:....||.|..|..|.|.
  Rat   197 NAFTQLGKLRFLNLSANELQPSLRHAATFVPLRSLSTLILSANSLQHLGPRVFQHLPRLGLLSLS 261

  Fly   249 GAGLHNISGDALKGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRE 313
            |..|.:::.:|..||.:||.|.|..|||..:|....:.|..||.|::..|:...:....|.....
  Rat   262 GNQLTHLAPEAFWGLEALRELRLEGNRLNQLPLTLLEPLHSLEALDLSGNELSALHPATFGHQGR 326

  Fly   314 LRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLD 378
            ||.|.                                                  |:.|.||:|.
  Rat   327 LRELS--------------------------------------------------LRDNALSALS 341

  Fly   379 EGLVPWAD-LQTLDLSENPFECDCRLLWLRHLLVSRNASGQYAPVI--CAYPTALRDLPLAHLAE 440
            ..:...:. |..|||..|.:.|||||..|:..:.:.::.|:...|.  |.:|.|||...|.:|.:
  Rat   342 GDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGNWHSQGRLLTVFVQCRHPPALRGKYLDYLDD 406

  Fly   441 PLL---GCAHGAASKQAIIGILVVACAALITTLALVLYTCRHRIREMLKGHSALGRKEREYQKTF 502
            .||   .|...:.|..|                                       ..|::.   
  Rat   407 QLLQNGSCVDPSPSPTA---------------------------------------GSRQWP--- 429

  Fly   503 SDEEYMSRPPPGGGGVHPAAGGYPYIAGNSRMIPVTELXLEAPPPPQLRGRGGGGGASTASGAVQ 567
                 :|..|  |.|:.|.||            ...|| |:..|.||.|||...|.|  .:||.:
  Rat   430 -----ISTAP--GEGMTPPAG------------LAQELPLQPQPQPQQRGRLLPGVA--WAGAAK 473

  Fly   568 QL------------------QVPSAVDQASNSFAQLSHIHYMTNNGQQQQAQQQQSTSKMHHSQQ 614
            :|                  |.|||. .||.|..|...:|.....|:..:|...|:         
  Rat   474 ELVGNRSALRLNRRGPGLQHQSPSAA-AASGSAPQSLDLHEKPERGRPTRANLPQT--------- 528

  Fly   615 DMRLLACNGGKPLNATSLPRHRPPVVQESTLSHYSQPLANGIRLTQDHFNHNQNQSHNQHYGGV- 678
                      :| ..||.|....|..::|......|.||:           .|.....|:..|| 
  Rat   529 ----------EP-TPTSEPASGTPSARDSWQRAAKQRLAS-----------EQQGRAVQYDSGVG 571

  Fly   679 ----YAKPCD 684
                .:.|||
  Rat   572 LPPLVSDPCD 581

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
capsNP_001303391.1 leucine-rich repeat 75..96 CDD:275380 4/25 (16%)
LRR_8 96..155 CDD:290566 22/82 (27%)
leucine-rich repeat 97..120 CDD:275380 6/22 (27%)
leucine-rich repeat 121..144 CDD:275380 11/46 (24%)
LRR_8 143..201 CDD:290566 19/57 (33%)
leucine-rich repeat 145..168 CDD:275380 7/22 (32%)
LRR_RI 147..397 CDD:238064 68/251 (27%)
leucine-rich repeat 169..192 CDD:275380 8/22 (36%)
leucine-rich repeat 193..217 CDD:275380 9/24 (38%)
LRR_8 217..276 CDD:290566 22/58 (38%)
leucine-rich repeat 218..241 CDD:275380 8/22 (36%)
leucine-rich repeat 242..265 CDD:275380 8/22 (36%)
LRR_8 265..321 CDD:290566 17/55 (31%)
leucine-rich repeat 266..289 CDD:275380 9/22 (41%)
leucine-rich repeat 290..313 CDD:275380 5/22 (23%)
LRR_8 312..374 CDD:290566 5/61 (8%)
leucine-rich repeat 314..335 CDD:275380 3/20 (15%)
leucine-rich repeat 339..363 CDD:275380 0/23 (0%)
LRRCT 395..445 CDD:214507 18/54 (33%)
TrilNP_001029182.1 LRR_RI 22..313 CDD:238064 84/293 (29%)
leucine-rich repeat 37..57 CDD:275378 2/19 (11%)
LRR 1 61..81 3/20 (15%)
LRR_8 84..143 CDD:290566 12/58 (21%)
LRR 2 84..105 7/20 (35%)
leucine-rich repeat 85..108 CDD:275380 6/22 (27%)
LRR 3 108..129 4/20 (20%)
leucine-rich repeat 109..132 CDD:275380 4/22 (18%)
LRR 4 132..153 5/20 (25%)
leucine-rich repeat 133..156 CDD:275380 7/22 (32%)
LRR_8 156..215 CDD:290566 20/58 (34%)
LRR 5 156..177 6/20 (30%)
leucine-rich repeat 157..180 CDD:275380 7/22 (32%)
LRR 6 180..201 7/20 (35%)
leucine-rich repeat 181..204 CDD:275380 8/22 (36%)
LRR 7 204..223 6/18 (33%)
leucine-rich repeat 205..230 CDD:275380 9/24 (38%)
LRR_8 229..289 CDD:290566 22/59 (37%)
LRR 8 230..251 7/20 (35%)
leucine-rich repeat 231..254 CDD:275380 8/22 (36%)
LRR 9 254..275 6/20 (30%)
leucine-rich repeat 255..278 CDD:275380 8/22 (36%)
LRR 10 278..298 8/19 (42%)
leucine-rich repeat 279..302 CDD:275380 9/22 (41%)
LRR_8 302..359 CDD:290566 17/106 (16%)
LRR 11 302..323 5/20 (25%)
leucine-rich repeat 303..323 CDD:275380 5/19 (26%)
LRR 12 326..347 8/70 (11%)
leucine-rich repeat 327..340 CDD:275378 7/62 (11%)
leucine-rich repeat 351..363 CDD:275378 5/11 (45%)
TPKR_C2 359..406 CDD:301599 16/46 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 414..460 17/106 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 486..562 22/107 (21%)
FN3 589..661 CDD:214495
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
32.870

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