DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and LRRTM1

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_849161.2	Gene:	LRRTM1 / 347730	HGNCID:	19408	Length:	522	Species:	Homo sapiens

Alignment Length:	484	Identity:	118/484 - (24%)
Similarity:	183/484 - (37%)	Gaps:	127/484 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LCLCL----------CLCLVLA---TLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNP 72
            |.|||          .|||:.|   .||.|  .:.||..|.|:...|...           |||
Human     6 LGLCLYWLLRRPSGVVLCLLGACFQMLPAA--PSGCPQLCRCEGRLLYCE-----------ALN- 56

  Fly    73 AIQRLVIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNK 137
                          :..:....:.|..|.|.:|.:..:....|....:|..|:||||.|..|...
Human    57 --------------LTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGD 107

  Fly   138 TFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNT 202
            .|..|..:..|.|..|.|.:|...||.||..|..::|..|::..:.|....||..|..|::..|.
Human   108 AFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANA 172

  Fly   203 LTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLR 267
            :..||..:                         |||.:                        ||:
Human   173 IQFVPVRI-------------------------FQDCR------------------------SLK 188

  Fly   268 FLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRR----V 328
            |||:..|:|.::...:|..|.:|.:|::..||...::...|..|..|..|      .|||    :
Human   189 FLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSL------CLRRNKVAI 247

  Fly   329 ESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLV-PWADLQTLDL 392
            ...:.....|||.::||.| ::..:.......:|||.::.|.:|:|:.::..:: .|..|.::.|
Human   248 VVSSLDWVWNLEKMDLSGN-EIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITL 311

  Fly   393 SENPFECD---CRLL-WLRHLLVSRNASGQY-APVICAYP------TALRDLPLAHL----AEPL 442
            :.|.::|.   |.|. ||      .|..|:| ..:.||.|      ..|..:...||    |||.
Human   312 AGNLWDCGRNVCALASWL------NNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLCEDGAEPT 370

  Fly   443 LGCAHGAASKQAIIGILVVACAALITTLA 471
            .|....|.:.::.:|    ..|:..||||
Human   371 SGHLLSAVTNRSDLG----PPASSATTLA 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	0/20 (0%)
		LRR_8	96..155	CDD:290566	18/58 (31%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	10/22 (45%)
		LRR_8	143..201	CDD:290566	17/57 (30%)
		leucine-rich repeat	145..168	CDD:275380	9/22 (41%)
		LRR_RI	147..397	CDD:238064	59/254 (23%)
		leucine-rich repeat	169..192	CDD:275380	6/22 (27%)
		leucine-rich repeat	193..217	CDD:275380	5/23 (22%)
		LRR_8	217..276	CDD:290566	9/58 (16%)
		leucine-rich repeat	218..241	CDD:275380	3/22 (14%)
		leucine-rich repeat	242..265	CDD:275380	0/22 (0%)
		LRR_8	265..321	CDD:290566	17/55 (31%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		LRR_8	312..374	CDD:290566	16/65 (25%)
		leucine-rich repeat	314..335	CDD:275380	5/24 (21%)
		leucine-rich repeat	339..363	CDD:275380	5/23 (22%)
		LRRCT	395..445	CDD:214507	18/64 (28%)
LRRTM1	NP_849161.2	LRR 1	64..87		5/22 (23%)
		LRR_8	73..125	CDD:290566	15/51 (29%)
		LRR_RI	<85..268	CDD:238064	60/238 (25%)
		LRR 2	89..111		9/21 (43%)
		leucine-rich repeat	91..114	CDD:275380	10/22 (45%)
		LRR 3	112..135		8/22 (36%)
		LRR_8	113..173	CDD:290566	18/59 (31%)
		leucine-rich repeat	115..138	CDD:275380	9/22 (41%)
		LRR 4	137..159		4/21 (19%)
		leucine-rich repeat	139..162	CDD:275380	6/22 (27%)
		LRR_8	161..221	CDD:290566	20/108 (19%)
		LRR 5	161..183		6/46 (13%)
		leucine-rich repeat	163..186	CDD:275380	8/71 (11%)
		LRR 6	184..207		8/46 (17%)
		leucine-rich repeat	187..210	CDD:275380	8/22 (36%)
		LRR 7	209..231		5/21 (24%)
		leucine-rich repeat	211..234	CDD:275380	6/22 (27%)
		LRR 8	233..255		5/27 (19%)
		leucine-rich repeat	235..257	CDD:275380	5/27 (19%)
		LRR 9	256..278		6/22 (27%)
		LRR_8	257..315	CDD:290566	15/58 (26%)
		LRR_4	257..297	CDD:289563	12/40 (30%)
		leucine-rich repeat	258..281	CDD:275380	5/23 (22%)
		LRR 10	279..302		6/22 (27%)
		leucine-rich repeat	282..300	CDD:275380	4/17 (24%)
		leucine-rich repeat	306..318	CDD:275378	3/11 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..401		6/18 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910